Search Results - "Urban, Jill P."

Tissue engineering and the intervertebral disc: the challenges by Kandel, Rita, Roberts, Sally, Urban, Jill P. G.

“…Disc degeneration is a common disorder. Although the back pain that can develop in association with this is rarely life-threatening, the annual cost in terms…”
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Controversies in regenerative medicine: Should intervertebral disc degeneration be treated with mesenchymal stem cells? by Loibl, Markus, Wuertz‐Kozak, Karin, Vadala, Gianluca, Lang, Siegmund, Fairbank, Jeremy, Urban, Jill P.

“…Low back pain (LBP) can significantly reduce the quality of life of patients, and has a considerable economic and social impact worldwide. It is commonly…”
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Current perspectives on the role of biomechanical loading and genetics in development of disc degeneration and low back pain; a narrative review by Urban, Jill P.G., Fairbank, Jeremy C.T.

“…Degenerative changes in the disc have long been of interest; they are thought to be strongly associated with low back pain and caused by inappropriate loading…”
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Metabolism of the intervertebral disc : Effects of low levels of oxygen, glucose, and pH on rates of energy metabolism of bovine nucleus pulposus cells by BIBBY, Susan R. S, JONES, Deborah A, RIPLEY, Ruth M, URBAN, Jill P. G

“…In vitro measurements of metabolic rates of isolated bovine nucleus pulposus cells at varying levels of oxygen, glucose, and pH. To obtain quantitative…”
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Factors regulating viable cell density in the intervertebral disc: blood supply in relation to disc height by Boubriak, Olga. A., Watson, Natasha, Sivan, Sarit. S., Stubbens, Naomi, Urban, Jill P. G.

“…The intervertebral disc is an avascular tissue, maintained by a small population of cells that obtain nutrients mainly by diffusion from capillaries at the…”
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2001 Volvo Award Winner in basic science studies: Effect of nutrient supply on the viability of cells from the nucleus pulposus of the intervertebral disc by HORNER, Heather A, URBAN, Jill P. G

“…Disc cell viability was analyzed in relation to nutrient supply and cellular demand in vitro in a diffusion chamber. To determine relations among nutrient…”
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Nutrient gradients in engineered cartilage: Metabolic kinetics measurement and mass transfer modeling by Zhou, Shengda, Cui, Zhanfeng, Urban, Jill P.G

“…Since tissue-engineered cartilage is avascular, both nutrient supply and metabolic waste removal rely on diffusion. As a result, gradients of nutrients and…”
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Disc cell therapies: critical issues by Tibiletti, Marta, Kregar Velikonja, Nevenka, Urban, Jill P. G., Fairbank, Jeremy C. T.

“…Background Disc cell therapies, in which cells are injected into the degenerate disc in order to regenerate the matrix and restore function, appear to be an…”
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Biological challenges for regeneration of the degenerated disc using cellular therapies by Bendtsen, Michael, Bunger, Cody, Colombier, Pauline, Le Visage, Catherine, Roberts, Sally, Sakai, Daisuke, Urban, Jill P G

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The elastic fiber network of the anulus fibrosus of the normal and scoliotic human intervertebral disc by JING YU, FAIRBANK, Jeremy C. T, ROBERTS, Sally, URBAN, Jill P. G

“…Immunohistochemical study of elastic fibers in human intervertebral discs (IVD) collected at surgery from patients with scoliosis. To compare the elastic fiber…”
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Differential Gene Expression Profiling of Metalloproteinases and Their Inhibitors: A Comparison Between Bovine Intervertebral Disc Nucleus Pulposus Cells and Articular Chondrocytes by YING CUI, JING YU, URBAN, Jill P. G, YOUNG, David A

“…A comparative in vitro metalloproteinases and their inhibitors gene expression profile. To obtain a complete expression profile of matrix metalloproteinases…”
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Pathophysiology of the intervertebral disc and the challenges for MRI by Urban, Jill P.G., Winlove, C. Peter

“…Through its ability to make relatively noninvasive and repeatable measurements, MRI has a great deal to offer, not only to clinical diagnosis of intervertebral…”
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Cells from different regions of the intervertebral disc: Effect of culture system on matrix expression and cell phenotype by HORNER, Heather A, ROBERTS, Sally, BIELBY, Robert C, MENAGE, Janis, EVANS, Helen, URBAN, Jill P. G

“…This study examined how the culture system and region of cellular origin affect disc cell morphology and extracellular matrix production. To determine the role…”
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A needle micro-osmometer for determination of glycosaminoglycan concentration in excised nucleus pulposus tissue by Sivan, Sarit Sara, Merkher, Yulia, Wachtel, Ellen, Urban, Jill P. G., Lazary, Aron, Maroudas, Alice

“…Purpose Aggrecan is one of the major macromolecular components of the intervertebral disc (IVD) and its loss is an early sign of degeneration. Restoration of…”
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Bovine explant model of degeneration of the intervertebral disc by Roberts, Sally, Menage, Janis, Sivan, Sarit, Urban, Jill P G

“…Many new treatments for degeneration of the intervertebral disc are being developed which can be delivered through a needle. These require testing in model…”
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Effect of Extracellular pH on Matrix Synthesis by Chondrocytes in 3D Agarose Gel by Wu, Min-Hsien, Urban, Jill P.G., Cui, Zhan Feng, Cui, Zheng, Xu, Xia

“…In cartilage tissue engineering, the determination of the most appropriate cell/tissue culture conditions to maximize extracellular matrix synthesis is of…”
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The elastic network of articular cartilage: an immunohistochemical study of elastin fibres and microfibrils by Yu, Jing, Urban, Jill P. G.

“…The elastic network of articular cartilage was investigated by immunohistochemistry using specific antibodies to elastin and fibrillin‐1. Articular cartilage…”
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Introduction: disc degeneration: summary by An, Howard S, Anderson, Paul A, Haughton, Victor M, Iatridis, James C, Kang, James D, Lotz, Jeffrey C, Natarajan, Raghu N, Oegema, Jr, Theodore R, Roughley, Peter, Setton, Lori A, Urban, Jill P, Videman, Tapio, Andersson, Gunnar B J, Weinstein, James N

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Finite element study of nutrient diffusion in the human intervertebral disc by Sélard, Eric, Shirazi-Adl, A, Urban, Jill P G

“…The diffusion of small nutrients in the intervertebral human disc was examined using a finite element model. To investigate nutrient transport into the disc…”
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Development of PDMS microbioreactor with well-defined and homogenous culture environment for chondrocyte 3-D culture by Wu, Min Hsien, Urban, Jill P G, Cui, Zheng, Cui, Zhan Feng

“…Perfusion cell culture is believed to provide a stable culture environment due to the continuous supply of nutrients and removal of waste. However, the culture…”
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