Search Results - "Urban, B W."

Current assessment of targets and theories of anaesthesia by Urban, B.W.

“…Br J Anaesth 2002; 89: 167–83…”
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Direct inhibition by cannabinoids of human 5‐HT3A receptors: probable involvement of an allosteric modulatory site by Barann, M, Molderings, G, Brüss, M, Bönisch, H, Urban, B W, Göthert, M

“…Excised outside‐out patches from HEK293 cells stably transfected with the human (h) 5‐HT3A receptor cDNA were used to determine the effects of cannabinoid…”
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Concepts and correlations relevant to general anaesthesia by Urban, B.W., Bleckwenn, M

“…Br J Anaesth 2002; 89: 3–16…”
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Molecular and functional changes in voltage-dependent na + channels following pilocarpine-induced status epilepticus in rat dentate granule cells by Ellerkmann, R.K., Remy, S., Chen, J., Sochivko, D., Elger, C.E., Urban, B.W., Becker, A., Beck, H.

“…Status epilepticus (S.E.) is known to lead to a large number of changes in the expression of voltage-dependent ion channels and neurotransmitter receptors. In…”
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The Effects of Morphine on Human 5-HT3A Receptors by Wittmann, Maria, Peters, I, Schaaf, T, Wartenberg, H C., Wirz, S, Nadstawek, J, Urban, B W., Barann, M

“…5-HT3 receptors are ligand-gated ion channels that are involved in the modulation of emesis and pain. In this study, we investigated whether the opioid…”
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Interaction of intravenous anesthetics with human Neuronal potassium currents in relation to clinical concentrations by FRIEDERICH, P, URBAN, B. W

“…Neuronal voltage-dependent potassium (K) currents are crucial for various cellular functions, such as the integration of temporal information in the central…”
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Bupivacaine inhibits human neuronal Kv3 channels in SH‐SY5Y human neuroblastoma cells by Friederich, P., Benzenberg, D., Urban, B.W.

“…Information on molecular targets that may be involved in the neurotoxicity of bupivacaine is limited. Suppression of Kv3 channels has been demonstrated to…”
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Correlation of the A-Line™ ARX index with acoustically evoked potential amplitude by Wenningmann, I., Paprotny, S., Strassmann, S., Ellerkmann, R.K., Rehberg, B., Soehle, M., Urban, B.W.

“…Automated indices derived from mid-latency auditory evoked potentials (MLAEP) have been proposed for monitoring the state of anaesthesia. The A-Line™ ARX index…”
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Comparison of the concentration-dependent effect of sevoflurane on the spinal H-reflex and the EEG in humans by Rehberg, B., Bouillon, T., Gruenewald, M., Schneider, J., Baars, J., Urban, B. W., Kox, W. J.

“…Background:  It has been shown that spinal reflexes such as the H‐reflex predict motor responses to painful stimuli better than cortical parameters derived…”
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Fast and slow interactions of n-alkanols with human 5-HT3A receptors: Implications for anesthetic mechanisms by Decker, A.-M., Witten, S., Barann, M., Urban, B.W.

“…This is part of a continuing patch-clamp study exploring molecular actions of anesthetics and systematically varied related substances on 5-HT3A receptors as…”
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Direct effects of morphine but not of fentanyl-type opioids on human 5-HT3A receptors in outside-out patch-clamp studies by Schaaf, T., Lyutenska, M., Urban, B.W., Wittmann, M.

“…Background The alkaloid morphine is historically the oldest opiate, yet still today it has clinically important uses in analgesic therapies. The main analgesic…”
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The site of anesthetic action by Urban, B W

“…The mechanisms of general anesthesia constitute one of the great unsolved problems of classical neuropharmacology. Since the discovery of general anesthesia,…”
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Carbamazepine Effects on Na+ Currents in Human Dentate Granule Cells from Epileptogenic Tissue by Reckziegel, G., Beck, H., Schramm, J., Urban, B. W., Elger, C. E.

“…Purpose: Carbamazepine (CBZ) is a well‐established drug in the therapy of temporal lobe epilepsy (TLE). The anticonvulsant action of CBZ has been explained…”
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Inhibition of 5-HT3 receptors by propofol : equilibrium and kinetic measurements by BARANN, M, DILGER, J. P, BÖNISCH, H, GÖTHERT, M, DYBEK, A, URBAN, B. W

“…Patch-clamp/rapid solution exchange experiments as well as tracer ([14C]-guanidinium) influx measurements were applied to investigate effects of propofol on…”
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Which agonist properties are important for the activation of 5-HT3A receptors? by Meiboom, M.F., Barann, M., Witten, S., Groeneveld, K., Urban, B.W.

“…Purpose: Why do anesthetics not activate excitatory ligand-gated ion channels such as 5-HT3 receptors in contrast to inhibitory ligand-gated ion channels? This…”
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Ketamine effects on human neuronal Na+ channels by Reckziegel, G, Friederich, P, Urban, B W

“…Similar doses of ketamine are employed in regional and general anaesthesia. In contrast to commonly used local anaesthetic agents, accidental systemic…”
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Ketamine and propofol differentially inhibit human neuronal K(+) channels by Friederich, P, Benzenberg, D, Urban, B W

“…Interaction of intravenous anaesthetic agents with voltage-dependent potassium channels significantly correlates with clinical concentrations. If potassium…”
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Molecular actions of racemic ketamine on human CNS sodium channels by Frenkel, C, Urban, B W

“…In search of a molecular site and mechanism of action for anaesthetics, we have examined the effects of racemic ketamine on single human CNS sodium channels…”
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Influence of sodium substitutes on 5‐HT‐mediated effects at mouse 5‐HT3 receptors by Barann, M, Schmidt, K, Göthert, M, Urban, B W, Bönisch, H

“…The influence of sodium ion substitutes on the 5‐hydroxytryptamine (5‐HT)‐induced flux of the organic cation [14C]guanidinium through the ion channel of the…”
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Anesthetic mechanisms in-vitro and in general anesthesia by Urban, B.W., Friederich, P.

“…1. There is no generally accepted and quantifiable definition of general anesthesia. 2. Ion channels are discussed as examples of in-vitro systems used to…”
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