Search Results - "Urbach, Valérie"
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Specialized proresolving mediator resolvin E1 corrects the altered cystic fibrosis nasal epithelium cilia beating dynamics
Published in Proceedings of the National Academy of Sciences - PNAS (30-01-2024)“…In cystic fibrosis (CF), impaired mucociliary clearance leads to chronic infection and inflammation. However, cilia beating features in a CF altered…”
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The Impact of Air Pollution on the Course of Cystic Fibrosis: A Review
Published in Frontiers in physiology (02-06-2022)“…Cystic fibrosis (CF) is a lethal and widespread autosomal recessive disorder affecting over 80,000 people worldwide. It is caused by mutations of the gene,…”
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Airway surface liquid acidification initiates host defense abnormalities in Cystic Fibrosis
Published in Scientific reports (24-04-2019)“…Cystic fibrosis (CF) is caused by defective Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) protein. Morbidity is mainly due to early airway…”
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Optimization of 3D islet-like cluster derived from human pluripotent stem cells: an efficient in vitro differentiation protocol
Published in Gene (15-12-2022)“…•This study presents a protocol that differentiates hiPSC into 3D glucose-responsive insulin-producing islet-like cluster.•This differentiation protocol…”
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DHA, RvD1, RvD5, and MaR1 reduce human coronary arteries contractions induced by PGE2
Published in Prostaglandins & other lipid mediators (01-04-2023)“…In patients with coronary artery disease (CAD), plasma levels of pro-inflammatory lipid mediators such as PGE2 and TxA2 are increased. They could increase…”
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Lipoxin A4 stimulates calcium-activated chloride currents and increases airway surface liquid height in normal and cystic fibrosis airway epithelia
Published in PloS one (25-05-2012)“…Cystic Fibrosis (CF) is a genetic disease characterised by a deficit in epithelial Cl(-) secretion which in the lung leads to airway dehydration and a reduced…”
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Author Correction: Airway surface liquid acidification initiates host defense abnormalities in Cystic Fibrosis
Published in Scientific reports (21-11-2019)“…An amendment to this paper has been published and can be accessed via a link at the top of the paper…”
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Physiological Impact of Abnormal Lipoxin A 4 Production on Cystic Fibrosis Airway Epithelium and Therapeutic Potential
Published in BioMed research international (2015)“…Lipoxin A 4 has been described as a major signal for the resolution of inflammation and is abnormally produced in the lungs of patients with cystic fibrosis…”
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Physiological Impact of Abnormal Lipoxin A4 Production on Cystic Fibrosis Airway Epithelium and Therapeutic Potential
Published in BioMed research international (01-01-2015)“…Lipoxin A4 has been described as a major signal for the resolution of inflammation and is abnormally produced in the lungs of patients with cystic fibrosis…”
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10
Sexual dimorphism and oestrogen regulation of KCNE3 expression modulates the functional properties of KCNQ1 K+ channels
Published in The Journal of physiology (01-11-2011)“…Non‐Technical Summary High levels of oestrogen are known to cause fluid retention in fertile females. It is thought that the increase in body fluid volume is…”
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An unexpected effect of TNF-α on F508del-CFTR maturation and function [version 2; peer review: 2 approved]
Published in F1000 research (01-01-2015)“…Cystic fibrosis (CF) is a multifactorial disease caused by mutations in the cystic fibrosis transmembrane conductance regulator gene ( CFTR), which encodes a…”
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Specialized Pro-Resolving Lipid Mediators in Cystic Fibrosis
Published in International journal of molecular sciences (21-09-2018)“…In cystic fibrosis (CF), impaired airway surface hydration (ASL) and mucociliary clearance that promote chronic bacterial colonization, persistent…”
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Lipoxin A4 and interleukin-8 levels in cystic fibrosis sputum after antibiotherapy
Published in Journal of cystic fibrosis (01-11-2008)“…Abstract Antibiotics are largely prescribed for cystic fibrosis (CF) respiratory exacerbations. Effects of antibiotics on the inflammatory profile of the…”
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Rapid Effects of Dexamethasone on Intracellular pH and Na+/H+ Exchanger Activity in Human Bronchial Epithelial Cells
Published in The Journal of biological chemistry (28-10-2005)“…Glucocorticoids have been shown to produce rapid nongenomic responses in airway epithelia. By using an intracellular pH (pHi) spectrofluorescence imaging…”
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Physiological levels of lipoxin A 4 inhibit ENaC and restore airway surface liquid height in cystic fibrosis bronchial epithelium
Published in Physiological reports (01-08-2014)Get full text
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The Role of Specialized Pro-Resolving Mediators in Cystic Fibrosis Airways Disease
Published in Frontiers in pharmacology (02-09-2020)“…Cystic Fibrosis (CF) is a recessive genetic disease due to mutations of the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) gene encoding the CFTR…”
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Correction of CFTR function in nasal epithelial cells from cystic fibrosis patients predicts improvement of respiratory function by CFTR modulators
Published in Scientific reports (07-08-2017)“…Clinical studies with modulators of the Cystic Fibrosis Transmembrane conductance Regulator (CFTR) protein have demonstrated that functional restoration of the…”
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CF Patients’ Airway Epithelium and Sex Contribute to Biosynthesis Defects of Pro-Resolving Lipids
Published in Frontiers in immunology (16-06-2022)“…Specialized pro-resolving lipid mediators (SPMs) as lipoxins (LX), resolvins (Rv), protectins (PD) and maresins (MaR) promote the resolution of inflammation…”
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19
An unexpected effect of TNF-α on F508del-CFTR maturation and function
Published in F1000 research (2015)“…Cystic fibrosis (CF) is a multifactorial disease caused by mutations in the cystic fibrosis transmembrane conductance regulator gene ( CFTR), which encodes a…”
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20
LXA4 stimulates ZO-1 expression and transepithelial electrical resistance in human airway epithelial (16HBE14o-) cells
Published in American journal of physiology. Lung cellular and molecular physiology (01-01-2009)“…Lipoxin A(4) (LXA(4)) is a biologically active eicosanoid produced in human airways that displays anti-inflammatory properties. In cystic fibrosis and severe…”
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