Influence of the parameters of encapsulation process and of the structure of diisocyanates on the release of codeine from resinate encapsulated in polyurea by interfacial water promoted polyreaction

Wet resinate beads consisting of carboxylic ion exchange resin and codeine have been coated with polyureas by use of interfacial water promoted polyreaction of various diisocyanates. Retardation of drug release from coated resinates was estimated based on the measurement of codeine concentration dur...

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Bibliographic Details
Published in:	Reactive & functional polymers Vol. 33; no. 2; pp. 233 - 239
Main Authors:	Łukaszczyk, Jan, Urbaś, Pawełl
Format:	Journal Article Conference Proceeding
Language:	English
Published:	Amsterdam Elsevier B.V 01-08-1997 Elsevier Science
Subjects:	Applied sciences Biological and medical sciences Codeine Diisocyanates Exact sciences and technology General pharmacology Medical sciences Microencapsulation Organic polymers Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Physicochemistry of polymers Properties and characterization Slow release Special properties (catalyst, reagent or carrier) Microencapsulation Slow release Diisocyanates Codeine Cationic resin Pharmaceutical technology Control release polymer Urea derivative polymer Drug carrier Kinetics Interface reaction Experimental study Property processing relationship Polyaddition Release
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Summary:	Wet resinate beads consisting of carboxylic ion exchange resin and codeine have been coated with polyureas by use of interfacial water promoted polyreaction of various diisocyanates. Retardation of drug release from coated resinates was estimated based on the measurement of codeine concentration during elution in simulated gastric juice. It has been found that the rate of codeine release depends on the parameters of encapsulation process: type of diisocyanate used, content of water in resinate, duration of swelling of resinate with water, diisocyanate/resinate weight ratio, reaction time and temperature.
ISSN:	1381-5148
DOI:	10.1016/S1381-5148(97)00044-8