Search Results - "Uray, Karen"

Mechanotransduction at the Plasma Membrane-Cytoskeleton Interface by Uray, Iván P, Uray, Karen

“…Mechanical cues are crucial for survival, adaptation, and normal homeostasis in virtually every cell type. The transduction of mechanical messages into…”
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The role of the microbiome in ovarian cancer: mechanistic insights into oncobiosis and to bacterial metabolite signaling by Sipos, Adrienn, Ujlaki, Gyula, Mikó, Edit, Maka, Eszter, Szabó, Judit, Uray, Karen, Krasznai, Zoárd, Bai, Péter

“…Ovarian cancer is characterized by dysbiosis, referred to as oncobiosis in neoplastic diseases. In ovarian cancer, oncobiosis was identified in numerous…”
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Mechanosensing in the Physiology and Pathology of the Gastrointestinal Tract by Kola, Job Baffin, Docsa, Tibor, Uray, Karen

“…Normal gastrointestinal function relies on sensing and transducing mechanical signals into changes in intracellular signaling pathways. Both specialized…”
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The Role of Inflammatory Mediators in the Development of Gastrointestinal Motility Disorders by Docsa, Tibor, Sipos, Adám, Cox, Charles S, Uray, Karen

“…Feeding intolerance and the development of ileus is a common complication affecting critically ill, surgical, and trauma patients, resulting in prolonged…”
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MicroRNA Regulatory Pathways in the Control of the Actin-Myosin Cytoskeleton by Uray, Karen, Major, Evelin, Lontay, Beata

“…MicroRNAs (miRNAs) are key modulators of post-transcriptional gene regulation in a plethora of processes, including actin-myosin cytoskeleton dynamics. Recent…”
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CXCL1 is upregulated during the development of ileus resulting in decreased intestinal contractile activity by Docsa, Tibor, Bhattarai, Deepa, Sipos, Adam, Wade, Charles E., Cox, Charles S., Uray, Karen

“…Background Although the development of ileus is widespread and negatively impacts patient outcomes, the mechanism by which ileus develops remains unclear. The…”
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Identification of Bacterial Metabolites Modulating Breast Cancer Cell Proliferation and Epithelial-Mesenchymal Transition by Ujlaki, Gyula, Kovács, Tünde, Vida, András, Kókai, Endre, Rauch, Boglára, Schwarcz, Szandra, Mikó, Edit, Janka, Eszter, Sipos, Adrienn, Hegedűs, Csaba, Uray, Karen, Nagy, Péter, Bai, Peter

“…Breast cancer patients are characterized by the oncobiotic transformation of multiple microbiome communities, including the gut microbiome. Oncobiotic…”
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Stretch-Induced Down-Regulation of HCN2 Suppresses Contractile Activity by Kola, Job Baffin, Turarova, Botagoz, Csige, Dora, Sipos, Ádám, Varga, Luca, Gergely, Bence, Refai, Farah Al, Uray, Iván P, Docsa, Tibor, Uray, Karen

“…Although hyperpolarization-activated and cyclic nucleotide-gated 2 channels (HCN2) are expressed in multiple cell types in the gut, the role of HCN2 in…”
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Oncobiosis and Microbial Metabolite Signaling in Pancreatic Adenocarcinoma by Kiss, Borbála, Mikó, Edit, Sebő, Éva, Toth, Judit, Ujlaki, Gyula, Szabó, Judit, Uray, Karen, Bai, Péter, Árkosy, Péter

“…Pancreatic adenocarcinoma is one of the most lethal cancers in both men and women, with a median five-year survival of around 5%. Therefore, pancreatic…”
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Tu1223 Inflammatory Cytokines Inhibit Myosin Light Chain Phosphorylation to Suppress Smooth Muscle Function in a Gut Manipulation Model of Postoperative Ileus by Uray, Karen S, Bhattarai, Deepa, Cox, Charles

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PET imaging of microglia using PBR28suv determines therapeutic efficacy of autologous bone marrow mononuclear cells therapy in traumatic brain injury by Bedi, Supinder S., Scott, Michael C., Skibber, Max A., Kumar, Akshita, Caplan, Henry W., Xue, Hasen, Sequeira, David, Speer, Alison L., Cardenas, Fanni, Gudenkauf, Franciska, Uray, Karen, Srivastava, Amit K., Prossin, Alan R., Cox, Charles S.

“…Traumatic brain injury (TBI) results in activated microglia. Activated microglia can be measured in vivo by using positron emission topography (PET) ligand…”
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Cyclobutane pyrimidine dimers from UVB exposure induce a hypermetabolic state in keratinocytes via mitochondrial oxidative stress by Hegedűs, Csaba, Juhász, Tamás, Fidrus, Eszter, Janka, Eszter Anna, Juhász, Gábor, Boros, Gábor, Paragh, György, Uray, Karen, Emri, Gabriella, Remenyik, Éva, Bai, Péter

“…Ultraviolet B radiation (UVB) is an environmental complete carcinogen, which induces and promotes keratinocyte carcinomas, the most common human malignancies…”
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The bacterial metabolite, lithocholic acid, has antineoplastic effects in pancreatic adenocarcinoma by Schwarcz, Szandra, Kovács, Patrik, Nyerges, Petra, Ujlaki, Gyula, Sipos, Adrienn, Uray, Karen, Bai, Péter, Mikó, Edit

“…Lithocholic acid (LCA) is a secondary bile acid. LCA enters the circulation after bacterial synthesis in the gastrointestinal tract, reaches distantly located…”
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Suppression of contractile activity in the small intestine by indomethacin and omeprazole by Lichtenberger, Lenard M, Bhattarai, Deepa, Phan, Tri M, Dial, Elizabeth J, Uray, Karen

“…Nonsteroidal anti-inflammatory drugs (NSAIDs) are widely used to treat a number of conditions, and proton pump inhibitors (PPIs) are often used to prevent…”
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Development of pulmonary fibrosis after heart failure induced by elevated left atrial pressure by Uray, Karen S, Peng, Zhanglong, Cattano, Davide, Eltzschig, Holger K, Doursout, Marie-Françoise

“…Chronic heart failure (CHF) is a common and serious complication of patients with ischemic heart disease that may eventually lead to the development of…”
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Resuscitation-Induced Intestinal Edema and Related Dysfunction: State of the Science by Shah, Shinil K., D.O, Uray, Karen S., Ph.D, Stewart, Randolph H., D.V.M., Ph.D, Laine, Glen A., Ph.D, Cox, Charles S., M.D

“…High volume resuscitation and damage control surgical methods, while responsible for significantly decreasing morbidity and mortality from traumatic injuries,…”
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Smoothelin-Like Protein 1 Regulates Development and Metabolic Transformation of Skeletal Muscle in Hyperthyroidism by Major, Evelin, Győry, Ferenc, Horváth, Dániel, Keller, Ilka, Tamás, István, Uray, Karen, Fülöp, Péter, Lontay, Beáta

“…Hyperthyroidism triggers a glycolytic shift in skeletal muscle (SKM) by altering the expression of metabolic proteins, which is often accompanied by peripheral…”
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Therapeutic time window of multipotent adult progenitor therapy after traumatic brain injury by Bedi, Supinder S, Aertker, Benjamin M, Liao, George P, Caplan, Henry W, Bhattarai, Deepa, Mandy, Fanni, Mandy, Franciska, Fernandez, Luis G, Zelnick, Pamela, Mitchell, Matthew B, Schiffer, Walter, Johnson, Margaret, Denson, Emma, Prabhakara, Karthik, Xue, Hasen, Smith, Philippa, Uray, Karen, Olson, Scott D, Mays, Robert W, Cox, Jr, Charles S

“…Traumatic brain injury (TBI) is a major cause of death and disability. TBI results in a prolonged secondary central neuro-inflammatory response. Previously, we…”
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Dual-Target Compounds against Type 2 Diabetes Mellitus : Proof of Concept for Sodium Dependent Glucose Transporter (SGLT) and Glycogen Phosphorylase (GP) Inhibitors by Sipos, Ádám, Szennyes, Eszter, Hajnal, Nikolett Éva, Kun, Sándor, Szabó, Katalin E, Uray, Karen, Somsák, László, Docsa, Tibor, Bokor, Éva

“…A current trend in the quest for new therapies for complex, multifactorial diseases, such as diabetes mellitus (DM), is to find dual or even multi-target…”
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Nicotinamide-riboside shifts the differentiation of human primary white adipocytes to beige adipocytes impacting substrate preference and uncoupling respiration through SIRT1 activation and mitochondria-derived reactive species production by Nagy, Lilla, Rauch, Boglárka, Szerafin, Tamás, Uray, Karen, Tóth, Attila, Bai, Péter

“…Beige adipocytes play key roles in organismal energy and metabolic balance. In this study, we assessed whether the supplementation of human white adipocytes,…”
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