Search Results - "Uray, Ivan"

ARID1A Deficiency Impairs the DNA Damage Checkpoint and Sensitizes Cells to PARP Inhibitors by Shen, Jianfeng, Peng, Yang, Wei, Leizhen, Zhang, Wei, Yang, Lin, Lan, Li, Kapoor, Prabodh, Ju, Zhenlin, Mo, Qianxing, Shih, Ie-Ming, Uray, Ivan P, Wu, Xiangwei, Brown, Powel H, Shen, Xuetong, Mills, Gordon B, Peng, Guang

“…ARID1A, SWI/SNF chromatin remodeling complex subunit, is a recently identified tumor suppressor that is mutated in a broad spectrum of human cancers. Thus, it…”
Get more information

The SOX11 transcription factor is a critical regulator of basal-like breast cancer growth, invasion, and basal-like gene expression by Shepherd, Jonathan H, Uray, Ivan P, Mazumdar, Abhijit, Tsimelzon, Anna, Savage, Michelle, Hilsenbeck, Susan G, Brown, Powel H

“…Basal-like breast cancers (BLBCs) are aggressive breast cancers associated with poor survival. Defining the key drivers of BLBC growth will allow…”
Get full text

SLC22A5/OCTN2 expression in breast cancer is induced by estrogen via a novel intronic estrogen-response element (ERE) by Wang, Chunyu, Uray, Ivan P., Mazumdar, Abhijit, Mayer, Julie Ann, Brown, Powel H.

“…Estrogen signaling is a critical pathway that plays a key role in the pathogenesis of breast cancer. In a previous transcriptional profiling study, we…”
Get full text

Intramyocardial lipid accumulation in the failing human heart resembles the lipotoxic rat heart by Sharma, Saumya, Adrogue, Julia V., Golfman, Leonard, Uray, Ivan, Lemm, John, Youker, Keith, Noon, George P., Frazier, O. H., Taegtmeyer, Heinrich

“…ABSTRACT In animal models of lipotoxicity, accumulation of triglycerides within cardiomyocytes is associated with contractile dysfunction. However, whether…”
Get full text

Bexarotene - a novel modulator of AURKA and the primary cilium in VHL -deficient cells by Chowdhury, Pratim, Powell, Reid T, Stephan, Clifford, Uray, Ivan P, Talley, Tia, Karki, Menuka, Tripathi, Durga Nand, Park, Yong Sung, Mancini, Michael A, Davies, Peter, Dere, Ruhee

“…Loss of the gene von Hippel-Lindau ( ) is associated with loss of primary cilia and is causally linked to elevated levels of Aurora kinase A (AURKA). We…”
Get full text

Natural product β-thujaplicin inhibits homologous recombination repair and sensitizes cancer cells to radiation therapy by Zhang, Lihong, Peng, Yang, Uray, Ivan P., Shen, Jianfeng, Wang, Lulu, Peng, Xiangdong, Brown, Powel H., Tu, Wei, Peng, Guang

“…Investigation of natural products is an attractive strategy to identify novel compounds for cancer prevention and treatment. Numerous studies have shown the…”
Get full text

Mechanotransduction at the Plasma Membrane-Cytoskeleton Interface by Uray, Iván P, Uray, Karen

“…Mechanical cues are crucial for survival, adaptation, and normal homeostasis in virtually every cell type. The transduction of mechanical messages into…”
Get full text

Retinoids and Rexinoids in Cancer Prevention: From Laboratory to Clinic by Uray, Iván P., M.D., Ph.D, Dmitrovsky, Ethan, M.D, Brown, Powel H., M.D., Ph.D

“…Early in the age of modern medicine the consequences of vitamin A deficiency drew attention to the fundamental link between retinoid-dependent homeostatic…”
Get full text

Androgen receptor mutations associated with androgen insensitivity syndrome: a high content analysis approach leading to personalized medicine by Szafran, Adam T, Hartig, Sean, Sun, Huiying, Uray, Ivan P, Szwarc, Maria, Shen, Yuqing, Mediwala, Sanjay N, Bell, Jennifer, McPhaul, Michael J, Mancini, Michael A, Marcelli, Marco

“…Androgen insensitivity syndrome (AIS) is a rare disease associated with inactivating mutations of AR that disrupt male sexual differentiation, and cause a…”
Get full text

Akt phosphorylates and suppresses the transactivation of retinoic acid receptor alpha by Srinivas, Harish, Xia, Dianren, Moore, Nicole L, Uray, Ivan P, Kim, Heetae, Ma, Long, Weigel, Nancy L, Brown, Powel H, Kurie, Jonathan M

“…The transactivation of nuclear receptors is regulated by both ligand binding and phosphorylation. We previously showed that RARalpha (retinoic acid receptor…”
Get full text

Translation of Effects of Retinoids and Rexinoids: Extraction and Quality Assessment of RNA from Formalin-Fixed Tissues by Uray, Iván P, László, Loretta

“…Retinoids and rexinoids directly and selectively activate their nuclear receptors, resulting in changes in the transcript levels of their target genes…”
Get more information

Atypical antipsychotics induce both proinflammatory and adipogenic gene expression in human adipocytes in vitro by Sárvári, Anitta K., Veréb, Zoltán, Uray, Iván P., Fésüs, László, Balajthy, Zoltán

“…•Antipsychotics modulate the expression of adipogenic genes in human adipocytes.•Secretion of proinflammatory cytokine IL8 and MCP-1 is induced by…”
Get full text

ATO Increases ROS Production and Apoptosis of Cells by Enhancing Calpain-Mediated Degradation of the Cancer Survival Protein TG2 by Jambrovics, Károly, Póliska, Szilárd, Scholtz, Beáta, Uray, Iván P, Balajthy, Zoltán

“…Transglutaminase 2 (TG2) is a critical cancer cell survival factor that activates several signalling pathways to foster drug resistance, cancer stem cell…”
Get full text

The Role of ARID1A in the Nonestrogenic Modulation of IGF-1 Signaling by Jdeed, Sham, Erdős, Edina, Bálint, Bálint L, Uray, Iván P

“…Gaining pharmacologic access to the potential of ARID1A, a tumor suppressor protein, to mediate transcriptional control over cancer gene expression is an…”
Get full text

Zymogen granule protein 16B ( ZG16B ) is a druggable epigenetic target to modulate the mammary extracellular matrix by Lengyel, Máté, Molnár, Ádám, Nagy, Tamás, Jdeed, Sham, Garai, Ildikó, Horváth, Zsolt, Uray, Iván P.

“…Abstract High tissue density of the mammary gland is considered a pro‐tumorigenic factor, hence suppressing the stimuli that induce matrix buildup carries the…”
Get full text

Prevention of breast cancer: current state of the science and future opportunities by Uray, Ivan P, Brown, Powel H

“…Despite significant progress in breast cancer treatment, mammary tumours still represent the second most frequent cause of cancer-related death in women in the…”
Get more information

Stretch-Induced Down-Regulation of HCN2 Suppresses Contractile Activity by Kola, Job Baffin, Turarova, Botagoz, Csige, Dora, Sipos, Ádám, Varga, Luca, Gergely, Bence, Refai, Farah Al, Uray, Iván P, Docsa, Tibor, Uray, Karen

“…Although hyperpolarization-activated and cyclic nucleotide-gated 2 channels (HCN2) are expressed in multiple cell types in the gut, the role of HCN2 in…”
Get full text

Transglutaminase 2 programs differentiating acute promyelocytic leukemia cells in all-trans retinoic acid treatment to inflammatory stage through NF-κB activation by Jambrovics, Károly, Uray, Iván P, Keresztessy, Zsolt, Keillor, Jeffrey W, Fésüs, László, Balajthy, Zoltán

“…Differentiation syndrome (DS) is a life-threatening complication arising during retinoid treatment of acute promyelocytic leukemia (APL). Administration of…”
Get full text

The AP-1 transcription factor regulates postnatal mammary gland development by Shen, Qiang, Zhang, Yun, Uray, Ivan P., Hill, Jamal L., Kim, Hee-Tae, Lu, Chunhua, Young, Matthew R., Gunther, Edward J., Hilsenbeck, Susan G., Chodosh, Lewis A., Colburn, Nancy H., Brown, Powel H.

“…The AP-1 transcription factor is activated by multiple growth factors that are critical regulators of breast cell proliferation. We previously demonstrated…”
Get full text

Transglutaminase 2 associated with PI3K and PTEN in a membrane-bound signalosome platform blunts cell death by Jambrovics, Károly, Botó, Pál, Pap, Attila, Sarang, Zsolt, Kolostyák, Zsuzsanna, Czimmerer, Zsolt, Szatmari, Istvan, Fésüs, László, Uray, Iván P., Balajthy, Zoltán

“…Atypically expressed transglutaminase 2 (TG2) has been identified as a poor prognostic factor in a variety of cancers. In this study, we evaluated the…”
Get full text