Search Results - "Urano, Yasuharu"

Discovery of novel forkhead box O1 inhibitors for treating type 2 diabetes: improvement of fasting glycemia in diabetic db/db mice by Nagashima, Takeyuki, Shigematsu, Nobuharu, Maruki, Riyo, Urano, Yasuharu, Tanaka, Hirotsugu, Shimaya, Akiyoshi, Shimokawa, Teruhiko, Shibasaki, Masayuki

“…Excessive hepatic glucose production through the gluconeogenesis pathway is partially responsible for the elevated glucose levels observed in patients with…”
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FR235222, a fungal metabolite, is a novel immunosuppressant that inhibits mammalian histone deacetylase III. Structure determination by Mori, Hiroaki, Urano, Yasuharu, Kinoshita, Takayoshi, Yoshimura, Seiji, Takase, Shigehiro, Hino, Motohiro

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Effects of the novel Foxo1 inhibitor AS1708727 on plasma glucose and triglyceride levels in diabetic db/db mice by Tanaka, Hirotsugu, Nagashima, Takeyuki, Shimaya, Akiyoshi, Urano, Yasuharu, Shimokawa, Teruhiko, Shibasaki, Masayuki

“…Recent evidence suggests that the forkhead transcription factor Foxo1 plays an important role in the regulation of glucose and triglyceride metabolism at the…”
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High diastereofacial selectivity in nucleophilic additions to chiral acylsilanes by Nakada, Masahisa, Urano, Yasuharu, Kobayashi, Susumu, Ohno, Masaji

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Prevention of renal interstitial fibrosis via histone deacetylase inhibition in rats with unilateral ureteral obstruction by Kinugasa, Fumitaka, Noto, Takahisa, Matsuoka, Hideaki, Urano, Yasuharu, Sudo, Yuji, Takakura, Shoji, Mutoh, Seitaro

“…Abstract Acute rejection following renal transplantation has become manageable with the introduction of calcineurin inhibitors, FK506 and cyclosporine A…”
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FR235222, a fungal metabolite, is a novel immunosuppressant that inhibits mammalian histone deacetylase (HDAC). I. Taxonomy, fermentation, isolation and biological activities by Mori, Hiroaki, Urano, Yasuharu, Abe, Fumie, Furukawa, Satoko, Furukawa, Shigetada, Tsurumi, Yasuhisa, Sakamoto, Kazutoshi, Hashimoto, Michizane, Takase, Shigehiro, Hino, Motohiro, Fujii, Takashi

“…A cyclic tetrapeptide FR235222, a novel immunosuppressant, has been isolated from the fermentation broth of a fungus, Acremonium sp. No. 27082. FR235222 showed…”
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FR226807: a potent and selective phosphodiesterase type 5 inhibitor by Hosogai, Naomi, Hamada, Kaori, Tomita, Masayuki, Nagashima, Akira, Takahashi, Tokiko, Sekizawa, Toshihiro, Mizutani, Tsuyoshi, Urano, Yasuharu, Kuroda, Akio, Sawada, Kozo, Ozaki, Tohru, Seki, Jiro, Goto, Toshio

“…We describe the pharmacological characteristics of a novel phosphodiesterase type 5 inhibitor FR226807, N-(3,4-dimethoxybenzyl)-2-{[(1…”
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