Search Results - "Urakami, Takeo"

Recognition, Neutralization, and Clearance of Target Peptides in the Bloodstream of Living Mice by Molecularly Imprinted Polymer Nanoparticles: A Plastic Antibody by Hoshino, Yu, Koide, Hiroyuki, Urakami, Takeo, Kanazawa, Hiroaki, Kodama, Takashi, Oku, Naoto, Shea, Kenneth J

“…We report that simple, synthetic organic polymer nanoparticles (NPs) can capture and clear a target peptide toxin in the bloodstream of living mice. The…”
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Small GTPase R-Ras Regulates Integrity and Functionality of Tumor Blood Vessels by Sawada, Junko, Urakami, Takeo, Li, Fangfei, Urakami, Akane, Zhu, Weiquan, Fukuda, Minoru, Li, Dean Y., Ruoslahti, Erkki, Komatsu, Masanobu

“…We show that R-Ras, a small GTPase of the Ras family, is essential for the establishment of mature, functional blood vessels in tumors. The genetic disruption…”
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Folate Receptor-Targeted Aggregation-Enhanced Near-IR Emitting Silica Nanoprobe for One-Photon in Vivo and Two-Photon ex Vivo Fluorescence Bioimaging by Wang, Xuhua, Morales, Alma R, Urakami, Takeo, Zhang, Lifu, Bondar, Mykhailo V, Komatsu, Masanobu, Belfield, Kevin D

“…A two-photon absorbing (2PA) and aggregation-enhanced near-infrared (NIR) emitting pyran derivative, encapsulated in and stabilized by silica nanoparticles…”
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Accumulation of macromolecules in brain parenchyma in acute phase of cerebral infarction/reperfusion by Ishii, Takayuki, Asai, Tomohiro, Urakami, Takeo, Oku, Naoto

“…Abstract Ischemia–reperfusion injury is induced by recovery of blood flow after ischemia. This phenomenon is a main cause of ischemic brain injury. The…”
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A highly selective KIT inhibitor MOD000001 suppresses IgE-mediated mast cell activation by Nakamura, Yuki, Urakami, Takeo, Ishimaru, Kayoko, Vuong Tran, Nguyen Quoc, Shimizu, Takafumi, Sinko, William, Takahashi, Taisuke, Marappan, Sivapriya, Narayanan, Kishore, Poddutoori, Ramulu, Terada, Yoh, Nakao, Atsuhito

“…The KIT receptor tyrosine kinase and its ligand, stem cell factor (SCF), control proliferation and survival of mast cells. Thus, targeting KIT signaling may…”
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Peptide-Directed Highly Selective Targeting of Pulmonary Arterial Hypertension by Urakami, Takeo, Järvinen, Tero A.H, Toba, Michie, Sawada, Junko, Ambalavanan, Namasivayam, Mann, David, McMurtry, Ivan, Oka, Masahiko, Ruoslahti, Erkki, Komatsu, Masanobu

“…Pulmonary arterial hypertension (PAH) is a disorder of the pulmonary vasculature associated with elevated pulmonary vascular resistance. Despite recent…”
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Deep vascular imaging in wounds by two-photon fluorescence microscopy by Yanez, Ciceron O, Morales, Alma R, Yue, Xiling, Urakami, Takeo, Komatsu, Masanobu, Järvinen, Tero A H, Belfield, Kevin D

“…Deep imaging within tissue (over 300 μm) at micrometer resolution has become possible with the advent of two-photon fluorescence microscopy (2PFM). The…”
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In Vivo Distribution of Liposome-Encapsulated Hemoglobin Determined by Positron Emission Tomography by Urakami, Takeo, Kawaguchi, Akira T., Akai, Shuji, Hatanaka, Kentaro, Koide, Hiroyuki, Shimizu, Kosuke, Asai, Tomohiro, Fukumoto, Dai, Harada, Norihiro, Tsukada, Hideo, Oku, Naoto

“…Positron emission tomography (PET) is a noninvasive imaging technology that enables the determination of biodistribution of positron emitter‐labeled compounds…”
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Correction: Deep Vascular Imaging in Wounds by Two-Photon Fluorescence Microscopy by Yanez, Ciceron O, Morales, Alma R, Yue, Xiling, Urakami, Takeo, Komatsu, Masanobu, Järvinen, Tero A H, Belfield, Kevin D

“…[This corrects the article DOI: 10.1371/journal.pone.0067559.]…”
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Overexpression of the Csk homologous kinase (Chk tyrosine kinase) induces multinucleation: a possible role for chromosome-associated Chk in chromosome dynamics by Yamaguchi, N, Nakayama, Y, Urakami, T, Suzuki, S, Nakamura, T, Suda, T, Oku, N

“…The Csk family of non-receptor-type tyrosine kinases consists of Csk and the Csk homologous kinase Chk. Each enzyme suppresses the catalytic activity of Src…”
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Identification of MOD000001, A Novel Highly Selective and Orally Available KIT Inhibitor Designed for Treatment of Mast Cell-Associated Disorders by Urakami, Takeo, Takahashi, Taisuke, Shimizu, Takafumi, Sinko, William, Nakamura, Yuki, Ishimaru, Kayoko, Tran, Vuong, Poddutoori, Ramulu, Narayanan, Kishore, Marappan, Sivapriya, Nakao, Atsuhito, Terada, Yoh

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MOD000001, a Novel Highly Selective and Orally Available KIT Inhibitor, Suppresses Passive Cutaneous Anaphylactic (PCA) Reaction and Food Allergy in Mice by Nakao, Atsuhito, Urakami, Takeo, Nakamura, Yuki, Ishimaru, Kayoko, Tran, Vuong, Takahashi, Taisuke, Shimizu, Takafumi, Sinko, William, Gummadi, Venkateshwar, Dhudashiya, Amit, Babu, Ravikrishna, Terada, Yoh

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Design of Synthetic Polymer Nanoparticles that Capture and Neutralize a Toxic Peptide by Hoshino, Yu, Urakami, Takeo, Kodama, Takashi, Koide, Hiroyuki, Oku, Naoto, Okahata, Yoshio, Shea, Kenneth J.

“…Designed polymer nanoparticles (NPs) capable of binding and neutralizing a biomacromolecular toxin are prepared. A library of copolymer NPs is synthesized from…”
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Particle size-dependent triggering of accelerated blood clearance phenomenon by Koide, Hiroyuki, Asai, Tomohiro, Hatanaka, Kentaro, Urakami, Takeo, Ishii, Takayuki, Kenjo, Eriya, Nishihara, Masamichi, Yokoyama, Masayuki, Ishida, Tatsuhiro, Kiwada, Hiroshi, Oku, Naoto

“…A repeat-injection of polyethylene glycol-modified liposomes (PEGylated liposomes) causes a rapid clearance of them from the blood circulation in certain cases…”
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PET imaging of brain cancer with positron emitter-labeled liposomes by Oku, Naoto, Yamashita, Mina, Katayama, Yurie, Urakami, Takeo, Hatanaka, Kentaro, Shimizu, Kosuke, Asai, Tomohiro, Tsukada, Hideo, Akai, Shuji, Kanazawa, Hiroaki

“…Since nanocarriers such as liposomes are known to accumulate in tumors of tumor-bearing animals, and those that have entrapped a positron emitter can be used…”
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Specific delivery of an immunosuppressive drug to splenic B cells by antigen-modified liposomes and its antiallergic effect by Shimizu, Kosuke, Miyauchi, Haruna, Urakami, Takeo, Yamamura-Ichikawa, Kanae, Yonezawa, Sei, Asai, Tomohiro, Oku, Naoto

“…Background: Use of the reverse targeting drug delivery system (RT-DDS) is a new targeting strategy based on the specific delivery of drugs to immune cells in…”
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A Novel Vascular Homing Peptide Strategy to Selectively Enhance Pulmonary Drug Efficacy in Pulmonary Arterial Hypertension by Toba, Michie, Alzoubi, Abdallah, O’Neill, Kealan, Abe, Kohtaro, Urakami, Takeo, Komatsu, Masanobu, Alvarez, Diego, Järvinen, Tero A.H, Mann, David, Ruoslahti, Erkki, McMurtry, Ivan F, Oka, Masahiko

“…A major limitation in the pharmacological treatment of pulmonary arterial hypertension (PAH) is the lack of pulmonary vascular selectivity. Recent studies have…”
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Small molecule fluorophore and copolymer RGD peptide conjugates for ex vivo two-photon fluorescence tumor vasculature imaging by Morales, Alma R, Yanez, Ciceron O, Zhang, Yuanwei, Wang, Xuhua, Biswas, Sanchita, Urakami, Takeo, Komatsu, Masanobu, Belfield, Kevin D

“…Abstract We report the use of small molecule and block copolymer RGD peptide conjugates for deep ex vivo imaging of tumor vasculature in “whole” excised tumors…”
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Abstract 2307: Small GTPase R-Ras promotes normalization of tumor vasculature: a potential oxygen-sensing independent mechanism by Komatsu, Masanobu, Sawada, Junko, Urakami, Takeo, Li, Fangfei, Urakami, Akane

“…Abstract Newly formed blood vessels in tumors fail to mature into fully functional vessels due to the chronically angiogenic microenvironment. The functional…”
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Suppression of immune response by antigen-modified liposomes encapsulating model agents: A novel strategy for the treatment of allergy by Ichikawa, Kanae, Asai, Tomohiro, Shimizu, Kosuke, Yonezawa, Sei, Urakami, Takeo, Miyauchi, Haruna, Kawashima, Hiroto, Ishida, Tatsuhiro, Kiwada, Hiroshi, Oku, Naoto

“…A specific antigen-sensitized animal has antigen-specific immune cells that recognize the antigen. Therefore, an antigen-modified drug carrier would be…”
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