Search Results - "Urakami, Akane"

Structural studies of Chikungunya virus maturation by Yap, Moh Lan, Klose, Thomas, Urakami, Akane, Hasan, S. Saif, Akahata, Wataru, Rossmann, Michael G.

“…Cleavage of the alphavirus precursor glycoprotein p62 into the E2 and E3 glycoproteins before assembly with the nucleocapsid is the key to producing…”
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An Envelope-Modified Tetravalent Dengue Virus-Like-Particle Vaccine Has Implications for Flavivirus Vaccine Design by Urakami, Akane, Ngwe Tun, Mya Myat, Moi, Meng Ling, Sakurai, Atsuko, Ishikawa, Momoko, Kuno, Sachiko, Ueno, Ryuji, Morita, Kouichi, Akahata, Wataru

“…Dengue viruses (DENV) infect 50 to 100 million people each year. The spread of DENV-associated infections is one of the most serious public health problems…”
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Small GTPase R-Ras Regulates Integrity and Functionality of Tumor Blood Vessels by Sawada, Junko, Urakami, Takeo, Li, Fangfei, Urakami, Akane, Zhu, Weiquan, Fukuda, Minoru, Li, Dean Y., Ruoslahti, Erkki, Komatsu, Masanobu

“…We show that R-Ras, a small GTPase of the Ras family, is essential for the establishment of mature, functional blood vessels in tumors. The genetic disruption…”
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315 iPSC-derived CAR-iNKT cells targeting HER2 show prolonged tumor control and promote durable survival in a tumor xenograft model by Urakami, Akane, Shioya, Koichiro, Shigeura, Tomokuni, Matsumura, Tomio, Mishima, Yuji, Okoshi, Momoko, Koseki, Haruhiko, Zhang, Lilin

“…BackgroundInvariant natural killer T (iNKT) cells are a rare subset of T lymphocytes that express a semi-invariant TCR, which recognizes glycolipids presented…”
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A tetravalent dengue virus-like particle vaccine induces high levels of neutralizing antibodies and reduces dengue replication in non-human primates by Thoresen, Daniel, Matsuda, Kenta, Urakami, Akane, Ngwe Tun, Mya Myat, Nomura, Takushi, Moi, Meng Ling, Watanabe, Yuri, Ishikawa, Momoko, Hau, Trang Thi Thu, Yamamoto, Hiroyuki, Suzaki, Yuriko, Ami, Yasushi, Smith, Jonathan F, Matano, Tetsuro, Morita, Kouichi, Akahata, Wataru

“…Dengue virus (DENV) represents a significant global health burden, with 50% of the world's population at risk of infection, and there is an urgent need for…”
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Development of a Novel Virus-Like Particle Vaccine Platform That Mimics the Immature Form of Alphavirus by Urakami, Akane, Sakurai, Atsuko, Ishikawa, Momoko, Yap, Moh Lan, Flores-Garcia, Yevel, Haseda, Yasunari, Aoshi, Taiki, Zavala, Fidel P, Rossmann, Michael G, Kuno, Sachiko, Ueno, Ryuji, Akahata, Wataru

“…Virus-like particles (VLPs) are noninfectious multiprotein structures that are engineered to self-assemble from viral structural proteins. Here, we developed a…”
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Abstract 2307: Small GTPase R-Ras promotes normalization of tumor vasculature: a potential oxygen-sensing independent mechanism by Komatsu, Masanobu, Sawada, Junko, Urakami, Takeo, Li, Fangfei, Urakami, Akane

“…Newly formed blood vessels in tumors fail to mature into fully functional vessels due to the chronically angiogenic microenvironment. The functional impairment…”
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