Search Results - "Upton, Neil"

Preclinical Neuropathic Pain Assessment; the Importance of Translatability and Bidirectional Research by Fisher, Amy S, Lanigan, Michael T, Upton, Neil, Lione, Lisa A

“…For patients suffering with chronic neuropathic pain the need for suitable novel therapies is imperative. Over recent years a contributing factor for the lack…”
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The Antidepressant-Like Effects of a Clinically Relevant Dose of Ketamine Are Accompanied by Biphasic Alterations in Working Memory in the Wistar Kyoto Rat Model of Depression by McDonnell, Conor W, Dunphy-Doherty, Fionn, Rouine, Jennifer, Bianchi, Massimiliano, Upton, Neil, Sokolowska, Ewa, Prenderville, Jack A

“…Major depressive disorder (MDD) is the leading cause of disability worldwide. The majority of antidepressant drugs require several weeks or months of treatment…”
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The Neuroprotective Effect of a Specific P2X7 Receptor Antagonist Derives from its Ability to Inhibit Assembly of the NLRP3 Inflammasome in Glial Cells by Murphy, Niamh, Cowley, Thelma R., Richardson, Jill C., Virley, David, Upton, Neil, Walter, Daryl, Lynch, Marina A.

“…Release of interleukin (IL)‐1β from immunocompetent cells requires formation of the NACHT, LLR and PYD domains‐containing protein 3 (NLRP3) inflammasome and…”
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Circadian and dark-pulse activation of orexin/hypocretin neurons by Marston, Oliver J, Williams, Rhîannan H, Canal, Maria M, Samuels, Rayna E, Upton, Neil, Piggins, Hugh D

“…Temporal control of brain and behavioral states emerges as a consequence of the interaction between circadian and homeostatic neural circuits. This interaction…”
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Effects of pan- and subtype-selective N-methyl-D-aspartate receptor antagonists on cortical spreading depression in the rat: therapeutic potential for migraine by Peeters, Magali, Gunthorpe, Martin J, Strijbos, Paul J L M, Goldsmith, Paul, Upton, Neil, James, Michael F

“…Spreading depression (SD) has long been associated with the underlying pathophysiology of migraine. Evidence that the N-methyl-D-aspartate (NMDA) glutamate…”
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Donepezil impairs memory in healthy older subjects: behavioural, EEG and simultaneous EEG/fMRI biomarkers by Balsters, Joshua H, O'Connell, Redmond G, Martin, Mary P, Galli, Alessandra, Cassidy, Sarah M, Kilcullen, Sophia M, Delmonte, Sonja, Brennan, Sabina, Meaney, Jim F, Fagan, Andrew J, Bokde, Arun L W, Upton, Neil, Lai, Robert, Laruelle, Marc, Lawlor, Brian, Robertson, Ian H

“…Rising life expectancies coupled with an increasing awareness of age-related cognitive decline have led to the unwarranted use of psychopharmaceuticals,…”
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Orexin A Activates Locus Coeruleus Cell Firing and Increases Arousal in the Rat by Hagan, Jim J., Leslie, Ron A., Patel, Sara, Evans, Martyn L., Wattam, Trevor A., Holmes, Steve, Benham, Christopher D., Taylor, Stephen G., Routledge, Carol, Hemmati, Panida, Munton, Richard P., Ashmeade, Tracey E., Shah, Ajit S., Hatcher, Jonathan P., Hatcher, Paula D., Declan N. C. Jones, Smith, Martin I., Piper, David C., Hunter, A. Jackie, Porter, Rod A., Upton, Neil

“…The localization of orexin neuropeptides in the lateral hypothalamus has focused interest on their role in ingestion. The orexigenic neurones in the lateral…”
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The novel brain neuropeptide, orexin-A, modulates the sleep-wake cycle of rats by Piper, David C., Upton, Neil, Smith, Martin I., Hunter, A. Jackie

“…Orexin‐A is a novel neuropeptide initially isolated from hypothalamic extracts but now known to be present in fibres distributed throughout the rat CNS…”
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SB-649915-B, a novel 5-HT1A/B autoreceptor antagonist and serotonin reuptake inhibitor, is anxiolytic and displays fast onset activity in the rat high light social interaction test by Starr, Kathryn R, Price, Gary W, Watson, Jeannette M, Atkinson, Peter J, Arban, Roberto, Melotto, Sergio, Dawson, Lee A, Hagan, Jim J, Upton, Neil, Duxon, Mark S

“…Preclinically, the combination of an SSRI and 5-HT autoreceptor antagonist has been shown to reduce the time to onset of anxiolytic activity compared to an…”
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BACE1 (beta-secretase) transgenic and knockout mice: identification of neurochemical deficits and behavioral changes by Harrison, Steve M, Harper, Alex J, Hawkins, Julie, Duddy, Graham, Grau, Evelyn, Pugh, Pippa L, Winter, Panida H, Shilliam, Claire S, Hughes, Zoë A, Dawson, Lee A, Gonzalez, M Isabel, Upton, Neil, Pangalos, Menelas N, Dingwall, Colin

“…BACE1 is a key enzyme in the generation of Abeta, the major component of senile plaques in the brains of Alzheimer's disease patients. We have generated…”
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Characterization of SB‐269970‐A, a selective 5‐HT7 receptor antagonist by Hagan, Jim J, Price, Gary W, Jeffrey, Phillip, Deeks, Nigel J, Stean, Tania, Piper, David, Smith, Martin I, Upton, Neil, Medhurst, Andrew D, Middlemiss, Derek N, Riley, Graham J, Lovell, Peter J, Bromidge, Steven M, Thomas, David R

“…The novel 5‐HT7 receptor antagonist, SB‐269970‐A, potently displaced [3H]‐5‐CT from human 5‐HT7(a) (pKi 8.9±0.1) and 5‐HT7 receptors in guinea‐pig cortex (pKi…”
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Structurally novel histamine H3 receptor antagonists GSK207040 and GSK334429 improve scopolamine-induced memory impairment and capsaicin-induced secondary allodynia in rats by Medhurst, Andrew D, Briggs, Michael A, Bruton, Gordon, Calver, Andrew R, Chessell, Iain, Crook, Barry, Davis, John B, Davis, Robert P, Foley, Andrew G, Heslop, Teresa, Hirst, Warren D, Medhurst, Stephen J, Ociepka, Sandrine, Ray, Alison, Regan, Ciaran M, Sargent, Becky, Schogger, Joanne, Stean, Tania O, Trail, Brenda K, Upton, Neil, White, Trevor, Orlek, Barry, Wilson, David M

“…GSK207040 (5-[(3-cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)oxy]-N-methyl-2-pyrazinecarboxamide) and GSK334429…”
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Repeated administration of the noradrenergic neurotoxin N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine (DSP-4) modulates neuroinflammation and amyloid plaque load in mice bearing amyloid precursor protein and presenilin-1 mutant transgenes by Pugh, Perdita L, Vidgeon-Hart, Martin P, Ashmeade, Tracey, Culbert, Ainsley A, Seymour, Zoe, Perren, Marion J, Joyce, Flora, Bate, Simon T, Babin, Anna, Virley, David J, Richardson, Jill C, Upton, Neil, Sunter, David

“…Data indicates anti-oxidant, anti-inflammatory and pro-cognitive properties of noradrenaline and analyses of post-mortem brain of Alzheimer's disease (AD)…”
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Voxel-Based Analysis of 11C-PIB Scans for Diagnosing Alzheimer's Disease by Mikhno, Arthur, Devanand, Davangere, Pelton, Gregory, Cuasay, Katrina, Gunn, Roger, Upton, Neil, Lai, Robert Y, Libri, Vincenzo, Mann, J. John, Parsey, Ramin V

“…The positron emission tomography (PET) radioligand N-methyl-11C-2-(4-methylaminophenyl)-6-hydroxybenzothiazole (also known as 11C-6-OH-BTA-1 or 11C-PIB) binds…”
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Ketamine supresses REM sleep and markedly increases EEG gamma oscillations in the Wistar Kyoto rat model of treatment-resistant depression by Kantor, Sandor, Lanigan, Michael, Giggins, Lauren, Lione, Lisa, Magomedova, Lilia, de Lannoy, Inés, Upton, Neil, Duxon, Mark

“…Wistar–Kyoto (WKY) rats exhibit depression-like characteristics and decreased sensitivity to monoamine-based antidepressants, making them a suitable model of…”
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5-HT6 receptor antagonists as novel cognitive enhancing agents for Alzheimer’s disease by Upton, Neil, Chuang, Tsu Tshen, Hunter, Ann J., Virley, David J.

“…Summary Alzheimer’s disease (AD) is a devastating neurological condition characterized by a progressive decline in cognitive performance accompanied by…”
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A simultaneous ERP/fMRI investigation of the P300 aging effect by O'Connell, Redmond G, Balsters, Joshua H, Kilcullen, Sophia M, Campbell, William, Bokde, Arun W, Lai, Robert, Upton, Neil, Robertson, Ian H

“…Abstract One of the most reliable psychophysiological markers of aging is a linear decrease in the amplitude of the P300 potential, accompanied by a more…”
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Evaluation of Selective 5‑HT2C Agonists in Acute Seizure Models by Silenieks, Leonardo B, Carroll, Nicole K, Van Niekerk, Annalise, Van Niekerk, Emily, Taylor, Colleen, Upton, Neil, Higgins, Guy A

“…The 5-HT releaser/reuptake inhibitor fenfluramine has been recently reported to provide benefit as an adjunctive treatment for Dravet and Lennox-Gastaut…”
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Effects of the selective 5-HT 7 receptor antagonist SB-269970 in animal models of psychosis and cognition by Waters, Kerry A., Stean, Tania O., Hammond, Beverley, Virley, David J., Upton, Neil, Kew, James N.C., Hussain, Ishrut

“…► SB-269970 attenuated amphetamine- and PCP-induced activity in rats. ► SB-269970 reversed a temporal deficit in novel object recognition in rats with an MED…”
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Effects of the selective 5-HT7 receptor antagonist SB-269970 in animal models of psychosis and cognition by Waters, Kerry A., Stean, Tania O., Hammond, Beverley, Virley, David J., Upton, Neil, Kew, James N.C., Hussain, Ishrut

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