Search Results - "Uppu, Jaya"

Synthesis and biological evaluation of substituted N-(2-(1H-benzo[d]imidazol-2-yl)phenyl)cinnamides as tubulin polymerization inhibitors by Donthiboina, Kavitha, Anchi, Pratibha, Gurram, Sowmyasree, Sai Mani, Geeta, Lakshmi Uppu, Jaya, Godugu, Chandraiah, Shankaraiah, Nagula, Kamal, Ahmed

“…[Display omitted] •New N-(2-(1H-benzo[d]imidazol-2-yl)phenyl)cinnamides were synthesized.•The compound 12h showed potent activity against the cancer cell line…”
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Synthesis of Combretastatin‐A4 Carboxamidest that Mimic Sulfonyl Piperazines by a Molecular Hybridization Approach: in vitro Cytotoxicity Evaluation and Inhibition of Tubulin Polymerization by Jadala, Chetna, Sathish, Manda, Anchi, Pratibha, Tokala, Ramya, Lakshmi, Uppu Jaya, Reddy, Velma Ganga, Shankaraiah, Nagula, Godugu, Chandraiah, Kamal, Ahmed

“…Molecular hybridization approach is a promising structural modification tool to design new chemical entities (NCEs) by mimicking two different pharmacophoric…”
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Synthesis of 1-(Indol-2-yl)-phenoxazine hybrids from quinacetophenone precursors and their biological evaluation as DNA intercalating agents by Nunewar, Saiprasad N., Kotla, Naveen, Lakshmi Uppu, Jaya, Dixit, Apoorva, Pooladanda, Venkatesh, Godugu, Chandraiah, Tangellamudi, Neelima D.

“…An operationally simple reaction between quinacetophenone and aniline derivatives in the presence of triethylamine at room temperature afforded…”
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Synthesis of different heterocycles-linked chalcone conjugates as cytotoxic agents and tubulin polymerization inhibitors by Shankaraiah, Nagula, Nekkanti, Shalini, Brahma, Uma Rani, Praveen Kumar, Niggula, Deshpande, Namrata, Prasanna, Daasi, Senwar, Kishna Ram, Jaya Lakshmi, Uppu

“…[Display omitted] •New heterocycles-linked chalcone conjugates were synthesized.•Anticancer activity was tested on selected human cancer cell lines.•The…”
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Identification of phytoconstituents of Memecylon sisparense gamble leaf and evaluation against cisplatin-induced oxidative renal damage in mice by Uppu, Jaya, Challa, Veerabhadra, Bhattula, Devender, Naidu Vegi, Ganga, Jojula, Malathi, Syed, Asha

“…Background: Memecylon sisparense Gamble (MSG) belongs to Melastomataceae family, having a wide range of pharmacological activities such as antioxidant,…”
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Design and synthesis of thiadiazolo-carboxamide bridged β-carboline-indole hybrids: DNA intercalative topo-IIα inhibition with promising antiproliferative activity by Tokala, Ramya, Sana, Sravani, Lakshmi, Uppu Jaya, Sankarana, Prasanthi, Sigalapalli, Dilep Kumar, Gadewal, Nikhil, Kode, Jyoti, Shankaraiah, Nagula

“…[Display omitted] •Compound 12c displayed superlative cytotoxicity in the cancer cell lines.•Selectivity index of 12c is in the range of 14.90–25.26.•Compound…”
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Sulfamic acid promoted one-pot synthesis of phenanthrene fused-dihydrodibenzo-quinolinones: Anticancer activity, tubulin polymerization inhibition and apoptosis inducing studies by Kumar, Niggula Praveen, Thatikonda, Sowjanya, Tokala, Ramya, Kumari, S. Sujana, Lakshmi, Uppu Jaya, Godugu, Chandraiah, Shankaraiah, Nagula, Kamal, Ahmed

“…[Display omitted] •Sulfamic acid promoted synthesis of phenanthrene fused-dihydrodibenzo-quinolinones.•Cytotoxicity on selected cancer cell lines and apoptosis…”
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Novel chromenyl-based 2-iminothiazolidin-4-one derivatives as tubulin polymerization inhibitors: Design, synthesis, biological evaluation and molecular modelling studies by Sigalapalli, Dilep Kumar, Pooladanda, Venkatesh, Kadagathur, Manasa, Guggilapu, Sravanthi Devi, Uppu, Jaya Lakshmi, Godugu, Chandraiah, Bathini, Nagendra Babu, Tangellamudi, Neelima D.

“…Here-in, we present molecular design, chemical synthesis and evaluation of novel chromenyl-based 2-iminothiazolidin-4-one derivatives as tubulin polymerization…”
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Design and synthesis of substituted dihydropyrimidinone derivatives as cytotoxic and tubulin polymerization inhibitors by Sana, Sravani, Tokala, Ramya, Bajaj, Deepti Madanlal, Nagesh, Narayana, Bokara, Kiran Kumar, Kiranmai, Gaddam, Lakshmi, Uppu Jaya, Vadlamani, Swapna, Talla, Venu, Shankaraiah, Nagula

“…[Display omitted] •A new series of 27 dihydropyrimidinone derivatives were synthesized using Biginelli protocol.•Compounds 10a-g showed cytotoxicity with the…”
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Synthesis and biological evaluation of curcumin inspired imidazo[1,2-a]pyridine analogues as tubulin polymerization inhibitors by Ramya, P.V. Sri, Guntuku, Lalita, Angapelly, Srinivas, Digwal, Chander Singh, Lakshmi, Uppu Jaya, Sigalapalli, Dilep Kumar, Babu, Bathini Nagendra, Naidu, V.G.M., Kamal, Ahmed

“…With an aim to develop new curcumin inspired analogues as potent anticancer agents, we synthesized a series of…”
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Discovery of certain benzyl/phenethyl thiazolidinone-indole hybrids as potential anti-proliferative agents: Synthesis, molecular modeling and tubulin polymerization inhibition study by Sigalapalli, Dilep Kumar, Pooladanda, Venkatesh, Singh, Priti, Kadagathur, Manasa, Guggilapu, Sravanthi Devi, Uppu, Jaya Lakshmi, Tangellamudi, Neelima D., Gangireddy, Pavan Kumar, Godugu, Chandraiah, Bathini, Nagendra Babu

“…[Display omitted] •The new benzyl/phenethyl thiazolidinone-indole hybrids were synthesized.•Synthesized compounds displayed prominent antiproliferative…”
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Apoptosis-driven synergistic anti-cancer efficacy of ethyl acetate extract of Memecylon sisparense Gamble leaves and doxorubicin in in-vitro and in-vivo models of triple-negative breast cancer by Uppu, Jaya Lakshmi, Challa, Veerabhadra Swamy, Syamprasad, N.P., Manepalli, Pavanprasanth, Naidu, VGM, Syed, Asha, Roshan, S., Tazneem, B., almalki, Waleed Hassan, Alharbi, Khalid Saad, Gupta, Gaurav

“…In the spectrum of breast neoplasms, approximately 15 to 20% of all diagnosed cases are triple-negative breast carcinoma. TNBC grows and spreads faster than…”
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