Search Results - "Uppu, Divakara S. S. M"

Small Molecular Antibacterial Peptoid Mimics: The Simpler the Better by Ghosh, Chandradhish, Manjunath, Goutham B, Akkapeddi, Padma, Yarlagadda, Venkateswarlu, Hoque, Jiaul, Uppu, Divakara S. S. M, Konai, Mohini M, Haldar, Jayanta

“…The emergence of multidrug resistant bacteria compounded by the depleting arsenal of antibiotics has accelerated efforts toward development of antibiotics with…”
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Cleavable Cationic Antibacterial Amphiphiles: Synthesis, Mechanism of Action, and Cytotoxicities by Hoque, Jiaul, Akkapeddi, Padma, Yarlagadda, Venkateswarlu, Uppu, Divakara S. S. M, Kumar, Pratik, Haldar, Jayanta

“…The development of novel antimicrobial agents having high selectivity toward bacterial cells over mammalian cells is urgently required to curb the widespread…”
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Membrane-active macromolecules kill antibiotic-tolerant bacteria and potentiate antibiotics towards Gram-negative bacteria by Uppu, Divakara S S M, Konai, Mohini M, Sarkar, Paramita, Samaddar, Sandip, Fensterseifer, Isabel C M, Farias-Junior, Celio, Krishnamoorthy, Paramanandam, Shome, Bibek R, Franco, Octávio L, Haldar, Jayanta

“…Chronic bacterial biofilms place a massive burden on healthcare due to the presence of antibiotic-tolerant dormant bacteria. Some of the conventional…”
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Aryl-Alkyl-Lysines: Agents That Kill Planktonic Cells, Persister Cells, Biofilms of MRSA and Protect Mice from Skin-Infection by Ghosh, Chandradhish, Manjunath, Goutham B, Konai, Mohini M, Uppu, Divakara S S M, Hoque, Jiaul, Paramanandham, Krishnamoorthy, Shome, Bibek R, Haldar, Jayanta

“…Development of synthetic strategies to combat Staphylococcal infections, especially those caused by methicillin resistant Staphyloccus aureus (MRSA), needs…”
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Membrane-active macromolecules resensitize NDM-1 gram-negative clinical isolates to tetracycline antibiotics by Uppu, Divakara S S M, Manjunath, Goutham B, Yarlagadda, Venkateswarlu, Kaviyil, Jyothi E, Ravikumar, Raju, Paramanandham, Krishnamoorthy, Shome, Bibek R, Haldar, Jayanta

“…Gram-negative 'superbugs' such as New Delhi metallo-beta-lactamase-1 (blaNDM-1) producing pathogens have become world's major public health threats…”
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Synthetic Charge-Invertible Polymer for Rapid and Complete Implantation of Layer-by-Layer Microneedle Drug Films for Enhanced Transdermal Vaccination by He, Yanpu, Hong, Celestine, Li, Jiahe, Howard, MayLin T, Li, Yingzhong, Turvey, Michelle E, Uppu, Divakara S. S. M, Martin, John R, Zhang, Ketian, Irvine, Darrell J, Hammond, Paula T

“…The utility of layer-by-layer (LbL) coated microneedle (MN) skin patches for transdermal drug delivery has proven to be a promising approach, with advantages…”
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Side Chain Degradable Cationic–Amphiphilic Polymers with Tunable Hydrophobicity Show in Vivo Activity by Uppu, Divakara S. S. M, Samaddar, Sandip, Hoque, Jiaul, Konai, Mohini M, Krishnamoorthy, Paramanandham, Shome, Bibek R, Haldar, Jayanta

“…Cationic–amphiphilic antibacterial polymers with optimal amphiphilicity generally target the bacterial membranes instead of mammalian membranes. To date, this…”
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A Biodegradable Polycationic Paint that Kills Bacteria in Vitro and in Vivo by Hoque, Jiaul, Akkapeddi, Padma, Ghosh, Chandradhish, Uppu, Divakara S. S. M, Haldar, Jayanta

“…Bacterial colonization and subsequent formation of biofilms onto surfaces of medical devices and implants is a major source of nosocomial infections. Most…”
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Broad Spectrum Antibacterial and Antifungal Polymeric Paint Materials: Synthesis, Structure–Activity Relationship, and Membrane-Active Mode of Action by Hoque, Jiaul, Akkapeddi, Padma, Yadav, Vikas, Manjunath, Goutham B, Uppu, Divakara S. S. M, Konai, Mohini M, Yarlagadda, Venkateswarlu, Sanyal, Kaustuv, Haldar, Jayanta

“…Microbial attachment and subsequent colonization onto surfaces lead to the spread of deadly community-acquired and hospital-acquired (nosocomial) infections…”
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Amide side chain amphiphilic polymers disrupt surface established bacterial bio-films and protect mice from chronic Acinetobacter baumannii infection by Uppu, Divakara S S M, Samaddar, Sandip, Ghosh, Chandradhish, Paramanandham, Krishnamoorthy, Shome, Bibek R, Haldar, Jayanta

“…Abstract Bacterial biofilms represent the root-cause of chronic or persistent infections in humans. Gram-negative bacterial infections due to nosocomial and…”
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Aryl-alkyl-lysines: Membrane-Active Small Molecules Active against Murine Model of Burn Infection by Ghosh, Chandradhish, Manjunath, Goutham B, Konai, Mohini M, Uppu, Divakara S. S. M, Paramanandham, Krishnamoorthy, Shome, Bibek R, Ravikumar, Raju, Haldar, Jayanta

“…Infections caused by drug-resistant Gram-negative pathogens continue to be significant contributors to human morbidity. The recent advent of New Delhi…”
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Lipopolysaccharide Neutralization by Cationic-Amphiphilic Polymers through Pseudoaggregate Formation by Uppu, Divakara S. S. M., Haldar, Jayanta

“…Synthetic polymers incorporating the cationic charge and hydrophobicity to mimic the function of antimicrobial peptides (AMPs) have been developed. These…”
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Polymers with tunable side-chain amphiphilicity as non-hemolytic antibacterial agents by Uppu, Divakara S S M, Akkapeddi, Padma, Manjunath, Goutham B, Yarlagadda, Venkateswarlu, Hoque, Jiaul, Haldar, Jayanta

“…Quaternized polymers mimicking the antimicrobial peptides were created by tuning the side-chain amphiphilicity using a first-time approach of…”
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l-Lysine based lipidated biphenyls as agents with anti-biofilm and anti-inflammatory properties that also inhibit intracellular bacteria by Ghosh, Chandradhish, Sarkar, Paramita, Samaddar, Sandip, Uppu, Divakara S S M, Haldar, Jayanta

“…l-Lysines were conjugated to lipidated biphenyls using simple synthetic chemistry to obtain selective membrane-active antibacterial agents that inhibit…”
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Temporal release of a three-component protein subunit vaccine from polymer multilayers by Uppu, Divakara S.S.M., Turvey, Michelle E., Sharif, Abdul Rahim Mohammed, Bidet, Katell, He, Yanpu, Ho, Victor, Tambe, Anagha D., Lescar, Julien, Tan, Ern Yu, Fink, Katja, Chen, Jianzhu, Hammond, Paula T.

“…Sustained antigen and adjuvant availability have been shown to improve antiviral immune responses following vaccination. Transcutaneous delivery of vaccines…”
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Surviving sepsis in the era of antibiotic resistance: Are there any alternative approaches to antibiotic therapy? by Uppu, Divakara S.S.M., Ghosh, Chandradhish, Haldar, Jayanta

“…Sepsis, a serious cause of morbidity in humans, has no proper single medication dedicated to it. In this review, we look at the current treatment modalities,…”
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Microneedle‐based intradermal delivery of stabilized dengue virus by Turvey, Michelle E., Uppu, Divakara S.S.M., Mohamed Sharif, Abdul Rahim, Bidet, Katell, Alonso, Sylvie, Ooi, Eng Eong, Hammond, Paula T.

“…Current live‐attenuated dengue vaccines require strict cold chain storage. Methods to preserve dengue virus (DENV) viability, which enable vaccines to be…”
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Correction: Membrane-active macromolecules resensitize NDM-1 gram-negative clinical isolates to tetracycline antibiotics by Uppu, Divakara S S M, Manjunath, Goutham B, Yarlagadda, Venkateswarlu, Kaviyil, Jyothi E, Ravikumar, Raju, Paramanandham, Krishnamoorthy, Shome, Bibek R, Haldar, Jayanta

“…Gram-negative 'superbugs' such as New Delhi metallo-beta-lactamase-1 (blaNDM-1) producing pathogens have become world's major public health threats…”
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Glycolipid-Anchored Proteins on Bioengineered Extracellular Vesicles for Lipopolysaccharide Neutralization by Uppu, Divakara SSM, Min, Yoohong, Kim, Inun, Kumar, Sumit, Park, Juhee, Cho, Yoon-Kyoung

“…Extracellular vesicles (EVs) with native membrane proteins possess a variety of functions. EVs have become increasingly important platforms for incorporating a…”
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Contribution of Extracellular Membrane Vesicles To the Secretome of Staphylococcus aureus by Uppu, Divakara Ssm, Wang, Xiaogang, Lee, Jean C

“…The microbial secretome modulates how the organism interacts with its environment. Included in the Staphylococcus aureus secretome are extracellular membrane…”
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