Pathology-based staging for HPV-positive squamous carcinoma of the oropharynx

Highlights • Multi-institutional surgical cohort of 704, p16-positive oropharynx cancer cases. • Existing AJCC/UICC pathologic staging lacked prognostic definition. • 3 “HPV path ” stages identified using pT-classification and node count (⩽4 vs ⩾5). • “HPV path ” stages were I (T1-T2, ⩽4), II (T1-T2...

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Published in:	Oral oncology Vol. 62; pp. 11 - 19
Main Authors:	Haughey, B.H, Sinha, P, Kallogjeri, D, Goldberg, R.L, Lewis, J.S, Piccirillo, J.F, Jackson, R.S, Moore, E.J, Brandwein-Gensler, M, Magnuson, S.J, Carroll, W.R, Jones, T.M, Wilkie, M.D, Lau, A, Upile, N.S, Sheard, Jon, Lancaster, J, Tandon, S, Robinson, M, Husband, D, Ganly, I, Shah, J.P, Brizel, D.M, O’Sullivan, B, Ridge, J.A, Lydiatt, W.M
Format:	Journal Article
Language:	English
Published:	England Elsevier Ltd 01-11-2016
Subjects:	Aged Alphapapillomavirus - isolation & purification Carcinoma, Squamous Cell - pathology Carcinoma, Squamous Cell - therapy Carcinoma, Squamous Cell - virology Disease-Free Survival Head and neck cancer Head and Neck Neoplasms - pathology Head and Neck Neoplasms - therapy Head and Neck Neoplasms - virology Hematology, Oncology and Palliative Medicine Human papillomavirus Humans Middle Aged Oropharynx cancer Otolaryngology P16 gene P16-positive Pathologic staging Prognosis Squamous Cell Carcinoma of Head and Neck Staging P16-positive Human papillomavirus Pathologic staging Staging Oropharynx cancer P16 gene Head and neck cancer
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Summary:	Highlights • Multi-institutional surgical cohort of 704, p16-positive oropharynx cancer cases. • Existing AJCC/UICC pathologic staging lacked prognostic definition. • 3 “HPV path ” stages identified using pT-classification and node count (⩽4 vs ⩾5). • “HPV path ” stages were I (T1-T2, ⩽4), II (T1-T2, ⩾5; T3-T4, ⩽4), and III (T3-T4, ⩾5).
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	1368-8375 1879-0593
DOI:	10.1016/j.oraloncology.2016.09.004