Search Results - "Uphues, Ingo"

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    The dual GCGR/GLP‐1R agonist survodutide: Biomarkers and pharmacological profiling for clinical candidate selection by Thomas, Leo, Martel, Eric, Rist, Wolfgang, Uphues, Ingo, Hamprecht, Dieter, Neubauer, Heike, Augustin, Robert

    Published in Diabetes, obesity & metabolism (01-06-2024)
    “…Aim To describe the biomarker strategy that was applied to select survodutide (BI 456906), BI 456908 and BI 456897 from 19 dual glucagon receptor (GCGR)/…”
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    Journal Article
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    749-P: Selection of BI 456906 as a Dual GCGR/GLP-1R Agonist Based on In Vitro Potency and In Vivo Target Engagement Biomarkers by AUGUSTIN, ROBERT, THOMAS, LEO, ZIMMERMANN, TINA, SIMON, ERIC, RIST, WOLFGANG, UPHUES, INGO, REINDL, WOLFGANG, KLEIN, THOMAS, NEUBAUER, HEIKE

    Published in Diabetes (New York, N.Y.) (20-06-2023)
    “…Glucagon (GCG) and glucagon-like peptide 1 (GLP-1) are peptide hormones that pharmacologically regulate bodyweight by increasing energy expenditure and…”
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    Alterations in β-Cell Calcium Dynamics and Efficacy Outweigh Islet Mass Adaptation in Compensation of Insulin Resistance and Prediabetes Onset by Chen, Chunguang, Chmelova, Helena, Cohrs, Christian M, Chouinard, Julie A, Jahn, Stephan R, Stertmann, Julia, Uphues, Ingo, Speier, Stephan

    Published in Diabetes (New York, N.Y.) (01-09-2016)
    “…Emerging insulin resistance is normally compensated by increased insulin production of pancreatic β-cells, thereby maintaining normoglycemia. However, it is…”
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    Discovery of BI-9787, a potent zwitterionic ketohexokinase inhibitor with oral bioavailability by Heine, Niklas, Weber, Alexander, Pautsch, Alexander, Gottschling, Dirk, Uphues, Ingo, Bauer, Margit, Ebenhoch, Rebecca, Magarkar, Aniket, Nosse, Bernd, Kley, Jörg Thomas

    Published in Bioorganic & medicinal chemistry letters (01-11-2024)
    “…[Display omitted] •Potent zwitterionic KHK inhibitor BI-9787 is a novel in vitro/in vivo tool compound.•Introduction of a carboxylic acid moiety leads to high…”
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    Alterations in [Beta]-Cell Calcium Dynamics and Efficacy Outweigh Islet Mass Adaptation in Compensation of Insulin Resistance and Prediabetes Onset by Chen, Chunguang, Chmelova, Helena, Cohrs, Christian M, Chouinard, Julie A, Jahn, Stephan R, Stertmann, Julia, Uphues, Ingo, Speier, Stephan

    Published in Diabetes (New York, N.Y.) (01-09-2016)
    “…Emerging insulin resistance is normally compensated by increased insulin production of pancreatic ...-cells, thereby maintaining normoglycemia. However, it is…”
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    Journal Article
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    Contraction-induced translocation of the glucose transporter Glut4 in isolated ventricular cardiomyocytes by Kolter, T, Uphues, I, Wichelhaus, A, Reinauer, H, Eckel, J

    “…Field stimulation of isolated adult ventricular cardiomyocytes was used to study the effect of contractile activity on 3-O-methylglucose transport and the…”
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    Molecular analysis of insulin resistance in isolated ventricular cardiomyocytes of obese Zucker rats by Kolter, T, Uphues, I, Eckel, J

    Published in The American journal of physiology (01-07-1997)
    “…Isolated ventricular cardiomyocytes obtained from lean and genetically (fa/fa) obese Zucker rats were used to correlate alterations of insulin-induced glucose…”
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    Diversification of cardiac insulin signaling involves the p85 alpha/beta subunits of phosphatidylinositol 3-kinase by Kessler, A, Uphues, I, Ouwens, D M, Till, M, Eckel, J

    “…Ventricular cardiomyocytes and cardiac tissue of lean and genetically obese (fa/fa) Zucker rats were used 1) to study the role of the p85 regulatory subunit…”
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    Insulin-dependent translocation of the small GTP-binding protein rab3C in cardiac muscle: studies on insulin-resistant Zucker rats by Uphues, Ingo, Chern, Yijuang, Eckel, Jürgen

    Published in FEBS letters (18-12-1995)
    “…The failure of insulin-regulated recruitment of the GLUT4 glucose transporter in cardiac muscle of obese Zucker rats is associated with alterations of the…”
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    Photoaffinity labelling of cardiac membrane GTP‐binding proteins in response to insulin by RUSS, Martina, WICHELHAUS, Antje, UPHUES, Ingo, KOLTER, Thomas, ECKEL, Jürgen

    Published in European journal of biochemistry (15-01-1994)
    “…Plasma membranes from rat cardiac ventricular tissue and insulin receptors partially purified by wheat‐germ‐agglutinin chromatography were subjected to direct…”
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