Search Results - "Uphues, Ingo"
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Plasma Dihydroceramides Are Diabetes Susceptibility Biomarker Candidates in Mice and Humans
Published in Cell reports (Cambridge) (28-02-2017)“…Plasma metabolite concentrations reflect the activity of tissue metabolic pathways and their quantitative determination may be informative about pathogenic…”
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2
BI 456906: Discovery and preclinical pharmacology of a novel GCGR/GLP-1R dual agonist with robust anti-obesity efficacy
Published in Molecular metabolism (Germany) (01-12-2022)“…Obesity and its associated comorbidities represent a global health challenge with a need for well-tolerated, effective, and mechanistically diverse…”
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3
The dual GCGR/GLP‐1R agonist survodutide: Biomarkers and pharmacological profiling for clinical candidate selection
Published in Diabetes, obesity & metabolism (01-06-2024)“…Aim To describe the biomarker strategy that was applied to select survodutide (BI 456906), BI 456908 and BI 456897 from 19 dual glucagon receptor (GCGR)/…”
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4
749-P: Selection of BI 456906 as a Dual GCGR/GLP-1R Agonist Based on In Vitro Potency and In Vivo Target Engagement Biomarkers
Published in Diabetes (New York, N.Y.) (20-06-2023)“…Glucagon (GCG) and glucagon-like peptide 1 (GLP-1) are peptide hormones that pharmacologically regulate bodyweight by increasing energy expenditure and…”
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5
Alterations in β-Cell Calcium Dynamics and Efficacy Outweigh Islet Mass Adaptation in Compensation of Insulin Resistance and Prediabetes Onset
Published in Diabetes (New York, N.Y.) (01-09-2016)“…Emerging insulin resistance is normally compensated by increased insulin production of pancreatic β-cells, thereby maintaining normoglycemia. However, it is…”
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6
Discovery of BI-9787, a potent zwitterionic ketohexokinase inhibitor with oral bioavailability
Published in Bioorganic & medicinal chemistry letters (01-11-2024)“…[Display omitted] •Potent zwitterionic KHK inhibitor BI-9787 is a novel in vitro/in vivo tool compound.•Introduction of a carboxylic acid moiety leads to high…”
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7
Crystal structures of human and mouse ketohexokinase provide a structural basis for species- and isoform-selective inhibitor design
Published in Acta crystallographica. Section D, Biological crystallography. (01-10-2023)“…A molecular understanding of the proteins involved in fructose metabolism is essential for controlling the current spread of fructose-related obesity, diabetes…”
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723-P: The Dual Glucagon and Glucagon-Like Peptide-1 Receptor (GCGR/GLP-1R) Agonist BI 4569Reduces Body Weight in Diet-Induced Obese Mice Based on Food Intake Reduction and an Increase in Energy Expenditure
Published in Diabetes (New York, N.Y.) (01-06-2022)“…BI 4569 is a synthetic peptide optimized to simultaneously engage the GCGR and GLP-1R. BI 4569 contains a fatty acid-based half-life extension that supports…”
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9
LKB1 and AMPK differentially regulate pancreatic β‐cell identity
Published in The FASEB journal (01-11-2014)“…Fully differentiated pancreatic β cells are essential for normal glucose homeostasis in mammals. Dedifferentiation of these cells has been suggested to occur…”
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10
Alterations in [Beta]-Cell Calcium Dynamics and Efficacy Outweigh Islet Mass Adaptation in Compensation of Insulin Resistance and Prediabetes Onset
Published in Diabetes (New York, N.Y.) (01-09-2016)“…Emerging insulin resistance is normally compensated by increased insulin production of pancreatic ...-cells, thereby maintaining normoglycemia. However, it is…”
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11
Contraction-induced translocation of the glucose transporter Glut4 in isolated ventricular cardiomyocytes
Published in Biochemical and biophysical research communications (15-12-1992)“…Field stimulation of isolated adult ventricular cardiomyocytes was used to study the effect of contractile activity on 3-O-methylglucose transport and the…”
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12
Hes3 Is Expressed in the Adult Pancreatic Islet and Regulates Gene Expression, Cell Growth, and Insulin Release
Published in The Journal of biological chemistry (19-12-2014)“…The transcription factor Hes3 is a component of a signaling pathway that supports the growth of neural stem cells with profound consequences in…”
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13
Molecular phenotyping of multiple mouse strains under metabolic challenge uncovers a role for Elovl2 in glucose-induced insulin secretion
Published in Molecular metabolism (Germany) (01-04-2017)“…Abstract Objective In type 2 diabetes (T2D), pancreatic β cells become progressively dysfunctional, leading to a decline in insulin secretion over time. In…”
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14
Molecular analysis of insulin resistance in isolated ventricular cardiomyocytes of obese Zucker rats
Published in The American journal of physiology (01-07-1997)“…Isolated ventricular cardiomyocytes obtained from lean and genetically (fa/fa) obese Zucker rats were used to correlate alterations of insulin-induced glucose…”
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15
Diversification of cardiac insulin signaling involves the p85 alpha/beta subunits of phosphatidylinositol 3-kinase
Published in American journal of physiology: endocrinology and metabolism (01-01-2001)“…Ventricular cardiomyocytes and cardiac tissue of lean and genetically obese (fa/fa) Zucker rats were used 1) to study the role of the p85 regulatory subunit…”
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Insulin-dependent translocation of the small GTP-binding protein rab3C in cardiac muscle: studies on insulin-resistant Zucker rats
Published in FEBS letters (18-12-1995)“…The failure of insulin-regulated recruitment of the GLUT4 glucose transporter in cardiac muscle of obese Zucker rats is associated with alterations of the…”
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17
Association of Impaired Phosphatidylinositol 3-Kinase Activity in GLUT1-Containing Vesicles with Malinsertion of Glucose Transporters into the Plasma Membrane of Fibroblasts from a Patient with Severe Insulin Resistance and Clinical Features of Werner Syndrome 1
Published in The journal of clinical endocrinology and metabolism (01-02-2000)Get full text
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18
Association of Impaired Phosphatidylinositol 3-Kinase Activity in GLUT1-Containing Vesicles with Malinsertion of Glucose Transporters into the Plasma Membrane of Fibroblasts from a Patient with Severe Insulin Resistance and Clinical Features of Werner Syndrome1
Published in The journal of clinical endocrinology and metabolism (01-02-2000)“…The purpose of this study was to examine the molecular mechanism responsible for the defective insulin-stimulated glucose transport in cultured fibroblasts…”
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19
Association of impaired phosphatidylinositol 3-kinase activity in GLUT1-containing vesicles with malinsertion of glucose transporters into the plasma membrane of fibroblasts from a patient with severe insulin resistance and clinical features of Werner syndrome
Published in The journal of clinical endocrinology and metabolism (01-02-2000)“…The purpose of this study was to examine the molecular mechanism responsible for the defective insulin-stimulated glucose transport in cultured fibroblasts…”
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20
Photoaffinity labelling of cardiac membrane GTP‐binding proteins in response to insulin
Published in European journal of biochemistry (15-01-1994)“…Plasma membranes from rat cardiac ventricular tissue and insulin receptors partially purified by wheat‐germ‐agglutinin chromatography were subjected to direct…”
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