Search Results - "Upham, Brad"

Applicability of Scrape Loading-Dye Transfer Assay for Non-Genotoxic Carcinogen Testing by Sovadinová, Iva, Upham, Brad L., Trosko, James E., Babica, Pavel

“…Dysregulation of gap junction intercellular communication (GJIC) is recognized as one of the key hallmarks for identifying non-genotoxic carcinogens (NGTxC)…”
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Phosphatidylcholine Specific PLC-Induced Dysregulation of Gap Junctions, a Robust Cellular Response to Environmental Toxicants, and Prevention by Resveratrol in a Rat Liver Cell Model by Sovadinova, Iva, Babica, Pavel, Böke, Hatice, Kumar, Esha, Wilke, Andrew, Park, Joon-Suk, Trosko, James E, Upham, Brad L

“…Dysregulation of gap junctional intercellular communication (GJIC) has been associated with different pathologies, including cancer; however, molecular…”
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Scrape Loading/Dye Transfer Assay by Babica, Pavel, Sovadinová, Iva, Upham, Brad L

“…The scrape loading/dye transfer (SL/DT) technique is a simple functional assay for the simultaneous assessment of gap junctional intercellular communication…”
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Bisphenol S enhances gap junction intercellular communication in ovarian theca cells by Gingrich, Jeremy, Pu, Yong, Upham, Brad L., Hulse, Madeline, Pearl, Sarah, Martin, Denny, Avery, Anita, Veiga-Lopez, Almudena

“…Gap junction intercellular communication (GJIC) is necessary for ovarian function, and it is temporospatially regulated during follicular development and…”
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Polycyclic aromatic hydrocarbon-induced signaling events relevant to inflammation and tumorigenesis in lung cells are dependent on molecular structure by Osgood, Ross S, Upham, Brad L, Hill, 3rd, Thomas, Helms, Katherine L, Velmurugan, Kalpana, Babica, Pavel, Bauer, Alison K

“…Polycyclic aromatic hydrocarbons (PAHs) are ubiquitous environmental and occupational toxicants, which are a major human health concern in the U.S. and abroad…”
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Secondhand Smoke-Prevalent Polycyclic Aromatic Hydrocarbon Binary Mixture-Induced Specific Mitogenic and Pro-inflammatory Cell Signaling Events in Lung Epithelial Cells by Osgood, Ross S, Upham, Brad L, Bushel, Pierre R, Velmurugan, Kalpana, Xiong, Ka-Na, Bauer, Alison K

“…Low molecular weight polycyclic aromatic hydrocarbons (LMW PAHs; < 206.3 g/mol) are prevalent and ubiquitous environmental contaminants, presenting a human…”
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The Carcinogenic Properties of Overlooked yet Prevalent Polycyclic Aromatic Hydrocarbons in Human Lung Epithelial Cells by Bauer, Alison K, Siegrist, Katelyn J, Wolff, Melanie, Nield, Lindsey, Brüning, Thomas, Upham, Brad L, Käfferlein, Heiko U, Plöttner, Sabine

“…The WHO classified air pollution as a human lung carcinogen and polycyclic aromatic hydrocarbons (PAHs) are components of both indoor (e.g., tobacco smoke and…”
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Single-walled carbon nanotubes dispersed in aqueous media via non-covalent functionalization: Effect of dispersant on the stability, cytotoxicity, and epigenetic toxicity of nanotube suspensions by Alpatova, Alla L., Shan, Wenqian, Babica, Pavel, Upham, Brad L., Rogensues, Adam R., Masten, Susan J., Drown, Edward, Mohanty, Amar K., Alocilja, Evangelyn C., Tarabara, Volodymyr V.

“…As the range of applications for carbon nanotubes (CNTs) rapidly expands, understanding the effect of CNTs on prokaryotic and eukaryotic cell systems has…”
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Early Mechanistic Events Induced by Low Molecular Weight Polycyclic Aromatic Hydrocarbons in Mouse Lung Epithelial Cells: A Role for Eicosanoid Signaling by Siegrist, Katelyn J, Romo, DeeDee, Upham, Brad L, Armstrong, Michael, Quinn, Kevin, Vanderlinden, Lauren, Osgood, Ross S, Velmurugan, Kalpana, Elie, Marc, Manke, Jonathan, Reinhold, Dominik, Reisdorph, Nichole, Saba, Laura, Bauer, Alison K

“…Abstract Low molecular weight polycyclic aromatic hydrocarbons (LMW PAHs; < 206.3 g/mol) are under regulated environmental contaminants (eg, secondhand smoke)…”
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Gap Junctional Intercellular Communication: A Functional Biomarker to Assess Adverse Effects of Toxicants and Toxins, and Health Benefits of Natural Products by Upham, Brad L, Sovadinová, Iva, Babica, Pavel

“…This protocol describes a scalpel loading-fluorescent dye transfer (SL-DT) technique that measures intercellular communication through gap junction channels,…”
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Chemopreventive Agents Attenuate Rapid Inhibition of Gap Junctional Intercellular Communication Induced by Environmental Toxicants by Babica, Pavel, Čtveráčková, Lucie, Lenčešová, Zuzana, Trosko, James E., Upham, Brad L.

“…Altered gap junctional intercellular communication (GJIC) has been associated with chemical carcinogenesis, where both chemical tumor promoters and…”
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Oxidative-dependent integration of signal transduction with intercellular gap junctional communication in the control of gene expression by Upham, Brad L, Trosko, James E

“…Research on oxidative stress focused primarily on determining how reactive oxygen species (ROS) damage cells by indiscriminate reactions with their…”
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Dysregulation of Gap Junction Function and Cytokine Production in Response to Non-Genotoxic Polycyclic Aromatic Hydrocarbons in an In Vitro Lung Cell Model by Romo, Deedee, Velmurugan, Kalpana, Upham, Brad L, Dwyer-Nield, Lori D, Bauer, Alison K

“…Polycyclic aromatic hydrocarbons (PAHs), prevalent contaminants in our environment, in many occupations, and in first and second-hand smoke, pose significant…”
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Toll-like receptor expression in human non-small cell lung carcinoma: potential prognostic indicators of disease by Bauer, Alison K, Upham, Brad L, Rondini, Elizabeth A, Tennis, Meredith A, Velmuragan, Kalpana, Wiese, David

“…Lung cancer remains the highest cause of cancer mortality worldwide. Toll-like receptors (TLR) are innate immune receptors that have both pro- and…”
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Risk, Stigma, Trustworthiness, and Citizen Participation-A Multifaceted Analysis of Media Coverage of Dioxin Contamination in Midland, Michigan by Zhuang, Jie, Cox, Jeffrey G, Chung, Minwoong, Hamm, Joseph A, Zwickle, Adam, Upham, Brad L

“…In the United States, more than 200 communities are designated by the U.S. Environmental Protection Agency as areas of concern for dioxins. Informing the…”
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Methoxychlor and Vinclozolin Induce Rapid Changes in Intercellular and Intracellular Signaling in Liver Progenitor Cells by Babica, Pavel, Zurabian, Rimma, Kumar, Esha R, Chopra, Rajus, Mianecki, Maxwell J, Park, Joon-Suk, Jaša, Libor, Trosko, James E, Upham, Brad L

“…Methoxychlor (MXC) and vinclozolin (VIN) are well-recognized endocrine disrupting chemicals known to alter epigenetic regulations and transgenerational…”
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Isothermal assay targeting class 1 integrase gene for environmental surveillance of antibiotic resistance markers by Stedtfeld, Robert D., Stedtfeld, Tiffany M., Waseem, Hassen, Fitschen-Brown, Meridith, Guo, Xueping, Chai, Benli, Williams, Maggie R., Shook, Trevor, Logan, Amanda, Graham, Ally, Chae, Jong-Chan, Sul, Woo-Jun, VanHouten, Jacob, Cole, James R., Zylstra, Gerben J., Tiedje, James M., Upham, Brad L., Hashsham, Syed A.

“…Antimicrobial resistance genes (ARGs) present in the environment pose a risk to human health due to potential for transfer to human pathogens. Surveillance is…”
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The Effect of Dioxin Contamination and Remediation on Property Values by Zwickle, Adam, Cox, Jeffrey G, Zhuang, Jie, Hamm, Joseph A, Upham, Brad L, Chung, Minwoong, Cruz, Shannon, Dearing, James W

“…Loss of property value is a major concern in communities faced with the toxic byproducts of industrial practices. Even after site remediation, stigma may…”
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The emperor wears no clothes in the field of carcinogen risk assessment: ignored concepts in cancer risk assessment by Trosko, James E., Upham, Brad L.

“…The following is a position paper challenging the paradigm that ‘carcinogen = mutagen’, and that the current rodent bioassay to predict risks to human cancers…”
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Environmental Stigma by Zhuang, Jie, Cox, Jeff, Cruz, Shannon, Dearing, James W, Hamm, Joseph A, Upham, Brad

“…This article examined the extent to which residents living in the Midland-Saginaw-Bay City area in Eastern Michigan felt stigmatized due to industrial…”
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