Search Results - "Upchurch, Katherine C"

Synthesis and immunostimulatory activity of substituted TLR7 agonists by Akinbobuyi, Babatope, Wang, Lei, Upchurch, Katherine C., Byrd, Matthew R., Chang, Charles A., Quintana, Jeremy M., Petersen, Rachel E., Seifert, Zacharie J., Boquin, José R., Oh, SangKon, Kane, Robert R.

“…[Display omitted] Fifteen new substituted adenines were synthesized as potential TLR7 agonists. These compounds, along with 9 previously reported compounds,…”
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New TLR7 agonists with improved humoral and cellular immune responses by Upchurch, Katherine C, Boquín, José R, Yin, Wenjie, Xue, Yaming, Joo, HyeMee, Kane, Robert R, Oh, SangKon

“…Highlights • We have developed two new TLR7 agonists, J4 and F4. • They induce phenotype maturation of antigen presenting cells (APCs). • However, they induce…”
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Preclinical Assessment of the Effectiveness of α-Dectin-1-Pam3 Conjugate in Controlling TH2 Responses by Upchurch, Katherine C., Horton, Joshua, Joo, HyeMee, Zhang, Wei, Ellis, Jerome, Zurawski, Sandy, Coffman, Robert L., Zurawski, Gerard, Kane, Bob, Miller, Lisa, Oh, Sangkon

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Facile syntheses of functionalized toll-like receptor 7 agonists by Akinbobuyi, Babatope, Byrd, Matthew R., Chang, Charles A., Nguyen, Mysa, Seifert, Zacharie J., Flamar, Anne-Laure, Zurawski, Gerard, Upchurch, Katherine C., Oh, SangKon, Dempsey, Stephen H., Enke, Thomas J., Le, John, Winstead, Hunter J., Boquín, José R., Kane, Robert R.

“…9 new TLR-7 agonists; 10–70% overall for 4–7 steps. X=H, I, CO2H, CN, CONH2, CCCH2OH, CCCH2NH2, (CH2)3NH2, CONHCH2CH2NH2, CONH-PEG2-NH2. [Display omitted]…”
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Preclinical Assessment of the Effectiveness of [alpha]-Dectin-1-Pam3 Conjugate in Controlling TH2 Responses by Upchurch, Katherine C, Horton, Joshua, Joo, HyeMee, Zhang, Wei, Ellis, Jerome, Zurawski, Sandy, Coffman, Robert L, Zurawski, Gerard, Kane, Bob, Miller, Lisa, Oh, Sangkon

“…In then NHP in vivo experiment, rhesus macaques were sensitized with house dust mite allergens and then treated with [alpha]-Dectin-1-Pam3…”
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Preclinical Assessment of the Effectiveness of α-Dectin-1-Pam3 Conjugate in Controlling TH 2 Responses by Upchurch, Katherine C, Horton, Joshua, Joo, HyeMee, PhD, Zhang, Wei, PhD, Ellis, Jerome, Zurawski, Sandy, MS, Coffman, Robert L., PhD, Zurawski, Gerard, PhD, Kane, Bob, PhD, Miller, Lisa, PhD, Oh, Sangkon, PhD

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