Search Results - "Upchurch, Clint M."

Macrophage phenotype and bioenergetics are controlled by oxidized phospholipids identified in lean and obese adipose tissue by Serbulea, Vlad, Upchurch, Clint M., Schappe, Michael S., Voigt, Paxton, DeWeese, Dory E., Desai, Bimal N., Meher, Akshaya K., Leitinger, Norbert

“…Adipose tissue macrophages (ATMs) adapt their metabolic phenotype either to maintain lean tissue homeostasis or drive inflammation and insulin resistance in…”
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The clinical relevance of heme detoxification by the macrophage heme oxygenase system by Yeudall, Scott, Upchurch, Clint M, Leitinger, Norbert

“…Heme degradation by the heme oxygenase (HMOX) family of enzymes is critical for maintaining homeostasis and limiting heme-induced tissue damage. Macrophages…”
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Macrophages sensing oxidized DAMPs reprogram their metabolism to support redox homeostasis and inflammation through a TLR2-Syk-ceramide dependent mechanism by Serbulea, Vlad, Upchurch, Clint M, Ahern, Katelyn W, Bories, Gael, Voigt, Paxton, DeWeese, Dory E, Meher, Akshaya K, Harris, Thurl E, Leitinger, Norbert

“…Macrophages control tissue homeostasis and inflammation by sensing and responding to environmental cues. However, the metabolic adaptation of macrophages to…”
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Distinct insulin granule subpopulations implicated in the secretory pathology of diabetes types 1 and 2 by Kreutzberger, Alex J B, Kiessling, Volker, Doyle, Catherine A, Schenk, Noah, Upchurch, Clint M, Elmer-Dixon, Margaret, Ward, Amanda E, Preobraschenski, Julia, Hussein, Syed S, Tomaka, Weronika, Seelheim, Patrick, Kattan, Iman, Harris, Megan, Liang, Binyong, Kenworthy, Anne K, Desai, Bimal N, Leitinger, Norbert, Anantharam, Arun, Castle, J David, Tamm, Lukas K

“…Insulin secretion from β-cells is reduced at the onset of type-1 and during type-2 diabetes. Although inflammation and metabolic dysfunction of β-cells elicit…”
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Adaptive thermogenesis in brown adipose tissue involves activation of pannexin-1 channels by Senthivinayagam, Subramanian, Serbulea, Vlad, Upchurch, Clint M., Polanowska-Grabowska, Renata, Mendu, Suresh K., Sahu, Srabani, Jayaguru, Prathiba, Aylor, Kevin W., Chordia, Mahendra D., Steinberg, Limor, Oberholtzer, Nathaniel, Uchiyama, Seichii, Inada, Noriko, Lorenz, Ulrike M., Harris, Thurl E., Keller, Susanna R., Meher, Akshaya K., Kadl, Alexandra, Desai, Bimal N., Kundu, Bijoy K., Leitinger, Norbert

“…Brown adipose tissue (BAT) is specialized in thermogenesis. The conversion of energy into heat in brown adipocytes proceeds via stimulation of β-adrenergic…”
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Endocannabinoid biosynthetic enzymes regulate pain response via LKB1-AMPK signaling by Chen, Miaomiao, Shin, Myungsun, Ware, Timothy B, Donvito, Giulia, Muchhala, Karan H, Mischel, Ryan, Mustafa, Mohammed A, Serbulea, Vlad, Upchurch, Clint M, Leitinger, Norbert, Akbarali, Hamid I, Lichtman, Aron H, Hsu, Ku-Lung

“…Diacylglycerol lipase-beta (DAGLβ) serves as a principal 2-arachidonoylglycerol (2-AG) biosynthetic enzyme regulating endocannabinoid and eicosanoid metabolism…”
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Virus‐induced Hepatic Expression of an Oxidized Phospholipid‐binding Antibody Fragment Prevents Initiation of Hepatic Steatosis and Progression to Fibrosis by Upchurch, Clint M., Yeudall, Scott, Pavelec, Caitlin M., Manjegowda, Mohan, Bochkis, Irina M., Scott, Michael, Perez‐Reyes, Edward, Leitinger, Norbert

“…Oxidized phospholipids have been implicated in chronic pathologies. It had been shown that hyperlipidemic LDL‐R‐deficient mice transgenic for a single chain…”
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Cardiomyocyte PANX1 Controls Glycolysis and Neutrophil Recruitment in Hypertrophy by Pavelec, Caitlin M, Young, Alexander P, Luviano, Hannah L, Orrell, Emily E, Szagdaj, Anna, Poudel, Nabin, Wolpe, Abigail G, Thomas, Samantha H, Yeudall, Scott, Upchurch, Clint M, Okusa, Mark D, Isakson, Brant E, Wolf, Matthew J, Leitinger, Norbert

“…PANX1 (pannexin 1), a ubiquitously expressed ATP release membrane channel, has been shown to play a role in inflammation, blood pressure regulation, and…”
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BAFF 60‐mer binding to BAFF receptor 3 utilizes the NF‐κB1 signaling pathway to hyperactivate B cells by Lempicki, Melissa D., Serbulea, Vlad, Paul, Saikat, Upchurch, Clint M., Sahu, Srabani, Gray, Jake A., Ailawadi, Gorav, Garcia, Brandon L., McNamara, Coleen, Leitinger, Norbert, Meher, Akshaya K.

“…B cell activating factor (BAFF) is a critical cytokine for survival, differentiation, proliferation, and antibody production of B cells. Abnormal B cell…”
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Impact of a short-term low calorie diet alone or with interval exercise on quality of life and oxidized phospholipids in obese females by Gilbertson, Nicole M., Eichner, Natalie Z.M., Gaitán, Julian M., Pirtle, John M., Kirby, Jennifer L., Upchurch, Clint M., Leitinger, Norbert, Malin, Steven K.

“…•A low calorie diet with interval exercise improved sexual life and emotions quality of life domains as well as total score more than a low calorie diet…”
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Mitochondrial Ca2+ Signaling Is an Electrometabolic Switch to Fuel Phagosome Killing by Seegren, Philip V., Downs, Taylor K., Stremska, Marta E., Harper, Logan R., Cao, Ruofan, Olson, Rachel J., Upchurch, Clint M., Doyle, Catherine A., Kennedy, Joel, Stipes, Eric L., Leitinger, Norbert, Periasamy, Ammasi, Desai, Bimal N.

“…Phagocytes reallocate metabolic resources to kill engulfed pathogens, but the intracellular signals that rapidly switch the immunometabolic program necessary…”
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BAFF antagonism via the BAFF receptor 3 binding site attenuates BAFF 60-mer-induced classical NF-κB signaling and metabolic reprogramming of B cells by D. Lempicki, Melissa, Paul, Saikat, Serbulea, Vlad, Upchurch, Clint M., Sahu, Srabani, Gray, Jake A., Ailawadi, Gorav, Garcia, Brandon L., McNamara, Coleen A., Leitinger, Norbert, Meher, Akshaya K.

“…•BAFF 3-mer, BAFF 60-mer, and higher order multimers are present in human plasma.•Compared to the BAFF 3-mer, BAFF 60-mer strongly induces the transcriptome of…”
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Macrophage acetyl-CoA carboxylase regulates acute inflammation through control of glucose and lipid metabolism by Yeudall, Scott, Upchurch, Clint M, Seegren, Philip V, Pavelec, Caitlin M, Greulich, Jan, Lemke, Michael C, Harris, Thurl E, Desai, Bimal N, Hoehn, Kyle L, Leitinger, Norbert

“…Acetyl-CoA carboxylase (ACC) regulates lipid synthesis; however, its role in inflammatory regulation in macrophages remains unclear. We generated mice that are…”
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Targeting oxidized phospholipids by AAV-based gene therapy in mice with established hepatic steatosis prevents progression to fibrosis by Upchurch, Clint M, Yeudall, Scott, Pavelec, Caitlin M, Merk, Dennis, Greulich, Jan, Manjegowda, Mohan, Raghavan, Shyam S, Bochkis, Irina M, Scott, Michael M, Perez-Reyes, Edward, Leitinger, Norbert

“…Oxidized phosphatidylcholines (OxPCs) are implicated in chronic tissue damage. Hyperlipidemic LDL-R--deficient mice transgenic for an OxPC-recognizing IgM…”
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265 - Dynamic Oxidized Phospholipid Composition within the Liver Plays a Role in Non-alcoholic Fatty Liver Disease Progression by Upchurch, Clint M, Serbulea, Vlad, Leitinger, Norbert

“…Non-alcoholic fatty liver disease (NAFLD), the hepatic manifestation of cardio-metabolic syndrome, affects up to 25% of individuals within the USA. NAFLD is a…”
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Dynamic Oxidized Phospholipid Composition within the Liver Plays a Role in Non-alcoholic Fatty Liver Disease Progression by Upchurch, Clint M, Serbulea, Vlad, Leitinger, Norbert

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Distinct insulin Granule Subpopulations Contribute to the Secretory Pathology of Diabetes Types 1 and 2 by Kiessling, Volker, Kreutzberger, Alex J.B., Doyle, Catherine A., Schenk, Noah, Upchurch, Clint M., Elmer-Dixon, Margaret M., Ward, Amanda E., Preobraschenski, Julia, Saad Hussain, Syed, Tomaka, Weronika, Seelheim, Patrick, Harris, Megan, Liang, Binyong, Castle, J.D., Tamm, Lukas K.

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Oxidized Phospholipids Differentially Reprogram Macrophages for Redox Homeostasis or Inflammation by Serbulea, Vlad, Upchurch, Clint M, Bories, Gael, Schappe, Michael S, DeWeese, Dory, Voigt, Paxton, Desai, Bimal, Meher, Akshaya, Leitinger, Norbert

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261 - Oxidized Phospholipids Differentially Reprogram Macrophages for Redox Homeostasis or Inflammation by Serbulea, Vlad, Upchurch, Clint M, Bories, Gael, Schappe, Michael S, DeWeese, Dory, Voigt, Paxton, Desai, Bimal, Meher, Akshaya, Leitinger, Norbert

“…Macrophages control tissue homeostasis by sensing and responding to redox stress signals. Here we show that macrophages selectively detect different oxidized…”
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Abstract 428: An Unexpected Role for ACC in Lipid Droplet Formation in Macrophages in Response to Acellular Adipocyte Fat by Meher, Akshaya K, Serbulea, Vlad, Upchurch, Clint M, Osinski, Victoria, Sahu, Srabani, Hargett, Stefan, Hoehn, Kyle L, Harris, Thurl E, Klibanov, Alexander L, McNamara, Coleen A, Leitinger, Norbert

“…Abstract only In adipose tissues of obese mice, macrophages accumulate in crown-like structures (CLS) formed around dying adipocytes. The CLS macrophages are…”
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