Search Results - "Upadhyay, Sunil K"

Redirecting abiraterone metabolism to fine-tune prostate cancer anti-androgen therapy by Li, Zhenfei, Alyamani, Mohammad, Li, Jianneng, Rogacki, Kevin, Abazeed, Mohamed, Upadhyay, Sunil K., Balk, Steven P., Taplin, Mary-Ellen, Auchus, Richard J., Sharifi, Nima

“…The prostate cancer drug abiraterone can be metabolized into several substances with different effects, and optimization of this process could be helpful for…”
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Adrenal-derived 11-oxygenated 19-carbon steroids are the dominant androgens in classic 21-hydroxylase deficiency by Turcu, Adina F, Nanba, Aya T, Chomic, Robert, Upadhyay, Sunil K, Giordano, Thomas J, Shields, James J, Merke, Deborah P, Rainey, William E, Auchus, Richard J

“…Abstract Objective To comprehensively characterize androgens and androgen precursors in classic 21-hydroxylase deficiency (21OHD) and to gain insights into the…”
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Development and validation of a novel LC–MS/MS method for simultaneous determination of abiraterone and its seven steroidal metabolites in human serum: Innovation in separation of diastereoisomers without use of a chiral column by Alyamani, Mohammad, Li, Zhenfei, Upadhyay, Sunil K., Anderson, David J., Auchus, Richard J., Sharifi, Nima

“…Abiraterone acetate (AA), the prodrug of abiraterone, is FDA-approved for the treatment of castration-resistant prostate cancer. Abiraterone is metabolized in…”
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Conversion of abiraterone to D4A drives anti-tumour activity in prostate cancer by Li, Zhenfei, Bishop, Andrew C., Alyamani, Mohammad, Garcia, Jorge A., Dreicer, Robert, Bunch, Dustin, Liu, Jiayan, Upadhyay, Sunil K., Auchus, Richard J., Sharifi, Nima

“…The drug abiraterone is converted to Δ 4 -abiraterone (D4A) in mice and patients with prostate cancer, which has more potent anti-tumour activity and may lead…”
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A-ring modified steroidal azoles retaining similar potent and slowly reversible CYP17A1 inhibition as abiraterone by Garrido, Mariana, Peng, Hwei-Ming, Yoshimoto, Francis K, Upadhyay, Sunil K, Bratoeff, Eugene, Auchus, Richard J

“…Abiraterone acetate is a potent inhibitor of human cytochrome P450c17 (CYP17A1, 17α-hydroxylase/17,20-lyase) and is clinically used in combination with…”
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Comparison of microwave-assisted and conventional preparations of cyclic imides by Upadhyay, Sunil K., Pingali, Subramanya R.K., Jursic, Branko S.

“…Microwave-assisted preparation of cyclic imides is superior with respect to isolated yield and length of reaction time when compared to conventional methods of…”
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Preparation of tagged glucose as a key intermediate in the synthesis of branched oligosaccharides by Upadhyay, Sunil K., Jursic, Branko S.

“…Tagged and activated d-glucose was introduced as a building block for branched oligosaccharides. This building block was the oligosaccharide branching point at…”
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Microwave-Assisted NBS Bromination of p-Iminotoluenes: Preparation of New Alcohol, Mercapto, and Amino Protection Groups by Upadhyay, Sunil K., Jursic, Branko S.

“…A simple, efficient, safe, high-yielding and rapid microwave-assisted method for the preparation of protected p-bromomethyl and p-dibromomethylanilines was…”
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Synthesis, spectral and oxidase studies of a new diamide copper(II) complex with pendant benzimidazolyl groups by Upadhyay, Sunil K., Tehlan, Sarita, Mathur, Pavan

“…A new benzimidazole-based diamide ligand- N, N′-bis(alanine-2-benzimidazolyl) hexanediamide (ABHA) has been synthesized and utilized to prepare Cu(II)…”
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Development of an Optimized Process for the Liver-Targeted Triantennary N‑Acetylgalactosamine Ligand by Kim, Joseph T., McPherson, Andrew K., Rodriguez, Andrew A., Chen, Lijian, Lu, Yee Fung, Moskalev, Nick, Upadhyay, Sunil K., Green, Caroline, Whetsell, Miranda, Xiang-Rong, Jiang, Trofimov, Alexander, Ring, Francis, Davalos, Ashley, Gabriel, Christopher M., Olsen, Phil

“…Development of a scalable process for N-acetylgalactosamine (GalNAc) ligand 1 is discussed. Multikilogram-scale synthesis of the GalNAc ligand is achieved in…”
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Conversion of abiraterone to D4A drives antitumor activity in prostate cancer by Li, Zhenfei, Bishop, Andrew, Alyamani, Mohammad, Garcia, Jorge A., Dreicer, Robert, Bunch, Dustin, Liu, Jiayan, Upadhyay, Sunil K., Auchus, Richard J., Sharifi, Nima

“…Prostate cancer resistance to castration occurs because tumors acquire the metabolic capability of converting precursor steroids to 5α-dihydrotestosterone…”
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