Search Results - "Upadhayay, Shubham"

Nrf2/HO-1 Signaling Activator Acetyl-11-keto-beta Boswellic Acid (AKBA)-Mediated Neuroprotection in Methyl Mercury-Induced Experimental Model of ALS by Minj, Elizabeth, Upadhayay, Shubham, Mehan, Sidharth

“…Methylmercury (MeHg) is a potent neurotoxin that causes neurotoxicity and neuronal cell death. MeHg exposure also leads to oligodendrocyte destruction, glial…”
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Inhibition of extracellular regulated kinase (ERK)-1/2 signaling pathway in the prevention of ALS: Target inhibitors and influences on neurological dysfunctions by Sahu, Rakesh, Upadhayay, Shubham, Mehan, Sidharth

“…[Display omitted] •ERK-1/2 signalling is required for neural cell proliferation, survival, and neurogenesis.•ALS is a motor neuron disease characterized by…”
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Involvement of the G-Protein-Coupled Estrogen Receptor-1 (GPER) Signaling Pathway in Neurodegenerative Disorders: A Review by Upadhayay, Shubham, Gupta, Rishav, Singh, Surbhi, Mundkar, Maroti, Singh, Gursewak, Kumar, Puneet

“…The G-protein-coupled estrogen receptor-1 (GPER) is an extranuclear estrogen receptor that regulates the expression of several downstream signaling pathways…”
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Ferulic acid ameliorates neurodegeneration via the Nrf2/ARE signalling pathway: A Review by Singh, Surbhi, Arthur, Richmond, Upadhayay, Shubham, Kumar, Puneet

“…•Ferulic acid is a potent antioxidant compound•Ferulic acid exerts neuroprotective effect in animal models of Alzheimer's disease•Ferulic acid has a potential…”
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Neuroprotection by solanesol against ethidium bromide-induced multiple sclerosis-like neurobehavioral, molecular, and neurochemical alterations in experimental rats by Sharma, Nidhi, Upadhayay, Shubham, Shandilya, Ambika, Sahu, Rakesh, Singh, Anshuman, Rajkhowa, Bidisha, Mehan, Sidharth

“…: Multiple Sclerosis (MS) is an idiopathic chronic neuroinflammatory disease characterized by neurodegeneration that clinically presents motor neuron…”
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Targeting Nrf2/HO-1 anti-oxidant signaling pathway in the progression of multiple sclerosis and influences on neurological dysfunctions by Upadhayay, Shubham, Mehan, Sidharth

“…•Nrf2/HO-1 anti-oxidant signaling is essential for neuronal cell proliferation, survival, and neurogenesis.•Involvement of Nrf2/HO-1 anti-oxidant signaling in…”
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Inhibition of c-JNK/p38MAPK signaling pathway by Apigenin prevents neurobehavioral and neurochemical defects in ethidium bromide-induced experimental model of multiple sclerosis in rats: Evidence from CSF, blood plasma and brain samples by Singh, Anshuman, Upadhayay, Shubham, Mehan, Sidharth

“…ØGliotoxin ethidium bromide causes pathological changes similar to MS in rats.Øc-JNK/p38 MAPK signaling pathway was found to be upregulated in the progression…”
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Bacillus Calmette-Guérin Vaccine Attenuates Haloperidol-Induced TD-like Behavioral and Neurochemical Alteration in Experimental Rats by Yedke, Narhari Gangaram, Upadhayay, Shubham, Singh, Randhir, Jamwal, Sumit, Ahmad, Sheikh F, Kumar, Puneet

“…Tardive dyskinesia (TD) is a hyperkinetic movement disorder that displays unusual involuntary movement along with orofacial dysfunction. It is predominantly…”
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Mitochondrial targeted antioxidants as potential therapy for huntington's disease by Upadhayay, Shubham, Kumar, Puneet

“…Huntington's disease (HD) is an inherited neurodegenerative disorder caused by an expansion in CAG repeat on huntington (Htt) gene, leading to a degeneration…”
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Understanding Abnormal c-JNK/p38MAPK Signaling Overactivation Involved in the Progression of Multiple Sclerosis: Possible Therapeutic Targets and Impact on Neurodegenerative Diseases by Singh, Anshuman, Upadhayay, Shubham, Mehan, Sidharth

“…Demyelination, immune dysregulation, and neuroinflammation are the most common triggers of motor neuron disorders such as multiple sclerosis (MS). MS is a…”
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Animal models of Huntington's disease and their applicability to novel drug discovery and development by Upadhayay, Shubham, Jamwal, Sumit, Kumar, Puneet

“…Huntington's disease (HD) is a progressive neurodegenerative disorder caused by an expansion in the CAG trinucleotide repeat in huntingtin (Htt) gene. The…”
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Impact of noscapine on halting the progression of pentylenetetrazole induced kindling epilepsy in mice by Gupta, Rishav, Soni, Divya, Upadhayay, Shubham, Dhureja, Maanvi, Kumar, Puneet

“…Abstract Epilepsy is caused by an excessive recurrent excitatory neuronal firing, characterized by motor, psychomotor, and sensory impairments. Current…”
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Crosstalk between gut–brain axis: unveiling the mysteries of gut ROS in progression of Parkinson’s disease by Soni, Divya, Upadhayay, Shubham, Dhureja, Maanvi, Arthur, Richmond, Kumar, Puneet

“…“Path to a good mood lies through the gut.” This statement seems to imply that it has long been believed that the gut is connected with the brain. Research has…”
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Monkeypox infection: The past, present, and future by Upadhayay, Shubham, Arthur, Richmond, Soni, Divya, Yadav, Poonam, Navik, UmaShanker, Singh, Randhir, Gurjeet Singh, Thakur, Kumar, Puneet

“…[Display omitted] •Monkeypox virus (MPXV) belongs to orthopoxvirus family, and its pathophysiology is similar to that of poxviruses.•MPXV spreads through…”
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Calcium channelopathies in neurodegenerative disorder: an untold story of RyR and SERCA by Dhureja, Maanvi, Arthur, Richmond, Soni, Divya, Upadhayay, Shubham, Temgire, Pooja, Kumar, Puneet

“…Recent neuroscience breakthroughs have shed light on the sophisticated relationship between calcium channelopathies and movement disorders, exposing a…”
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An Overview of the Pathophysiological Mechanisms of 3-Nitropropionic Acid (3-NPA) as a Neurotoxin in a Huntington's Disease Model and Its Relevance to Drug Discovery and Development by Upadhayay, Shubham, Yedke, Narhari Gangaram, Rahi, Vikrant, Singh, Surbhi, Kumar, Sachin, Arora, Anchal, Chandolia, Priyanka, Kaur, Prabhsharan, Kumar, Mandeep, Koshal, Prashant, Jamwal, Sumit, Kumar, Puneet

“…Animal models are used to better understand the various mechanisms involved in the pathogenesis of diseases and explore potential pathways that will aid in…”
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Nrf2/HO-1 Signaling Stimulation through Acetyl-11-Keto-Beta-Boswellic Acid (AKBA) Provides Neuroprotection in Ethidium Bromide-Induced Experimental Model of Multiple Sclerosis by Upadhayay, Shubham, Mehan, Sidharth, Prajapati, Aradhana, Sethi, Pranshul, Suri, Manisha, Zawawi, Ayat, Almashjary, Majed N, Tabrez, Shams

“…Multiple sclerosis (MS) is a severe immune-mediated neurological disease characterized by neuroinflammation, demyelination, and axonal degeneration in the…”
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In Vitro and In Vivo Investigations of Chromone Derivatives as Potential Multitarget-Directed Ligands: Cognitive Amelioration Utilizing a Scopolamine-Induced Zebrafish Model by Kumar, Naveen, Jangid, Kailash, Kumar, Vishal, Yadav, Ravi Prakash, Mishra, Jayapriya, Upadhayay, Shubham, Kumar, Vinay, Devi, Bharti, Kumar, Vijay, Dwivedi, Ashish Ranjan, Kumar, Puneet, Baranwal, Somesh, Bhatti, Jasvinder Singh, Kumar, Vinod

“…Alzheimer’s disease is a complex neurological disorder linked with multiple pathological hallmarks. The interrelation of therapeutic targets assists in the…”
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Neuroprotective efficacy of 4-Hydroxyisoleucine in experimentally induced intracerebral hemorrhage by Mehmood Siddiqui, Ehraz, Mehan, Sidharth, Upadhayay, Shubham, Khan, Andleeb, Halawi, Maryam, Ahmed Halawi, Azhar, Alsaffar, Rana M.

“…[Display omitted] Intracerebral hemorrhage (ICH) is a severe form of brain injury, which is a major cause of mortality in humans. Hydrocephalus and cerebral…”
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Big Data Analysis on Supply Chain Management by Rajyashree, R., Pathak, Prakarsh, Upadhayay, Shubham, Garg, Vaibhav

“…This paper intends to draw the versions of the given and the transcript form the Big Data over the given form of the supply chain, this demystifies the given…”
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