Simultaneous gastric, pancreatic, and renal metastasis from poorly differentiated hepatocellular carcinoma

Common extrahepatic metastasis sites of hepatocellular carcinoma (HCC) are the lungs, adrenal glands, and bones. Herein, we report a rare case of metastatic gastric, pancreatic, and renal tumors from HCC simultaneously, and review the relevant literature. A 75-year-old woman presented with right hyp...

Full description

Saved in:

Bibliographic Details
Published in:	Clinical journal of gastroenterology Vol. 17; no. 3; pp. 497 - 504
Main Authors:	Uchikoshi, Manabu, Ito, Takayoshi, Nakajima, Yoko, Sugiura, Ikuya, Uozumi, Shoujirou, Shimozuma, Yuu, Sakaki, Masashi, Ohira, Yasuyuki, Yamochi, Toshiko, Yoshida, Hitoshi
Format:	Journal Article
Language:	English
Published:	Singapore Springer Nature Singapore 01-06-2024
Subjects:	Abdominal Surgery Aged Carcinoma, Hepatocellular - diagnostic imaging Carcinoma, Hepatocellular - pathology Carcinoma, Hepatocellular - secondary Case Report Colorectal Surgery Fatal Outcome Female Gastroenterology Hepatology Humans Kidney Neoplasms - pathology Liver Neoplasms - diagnostic imaging Liver Neoplasms - pathology Liver Neoplasms - secondary Lung Neoplasms - pathology Lung Neoplasms - secondary Magnetic Resonance Imaging Medicine Medicine & Public Health Pancreatic Neoplasms - diagnostic imaging Pancreatic Neoplasms - pathology Pancreatic Neoplasms - secondary Stomach Neoplasms - pathology Stomach Neoplasms - secondary Surgical Oncology Tomography, X-Ray Computed Adenocarcinoma Hepatocellular carcinoma Extrahepatic metastasis
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	Common extrahepatic metastasis sites of hepatocellular carcinoma (HCC) are the lungs, adrenal glands, and bones. Herein, we report a rare case of metastatic gastric, pancreatic, and renal tumors from HCC simultaneously, and review the relevant literature. A 75-year-old woman presented with right hypochondralgia, appetite loss, and weight loss. Computed tomography revealed suspected metastatic liver, lung, and renal tumors. A blood test revealed a leukocyte count of 26,210/μL and a high inflammatory reaction. As sepsis was suspected, the patient was referred to our hospital. Gadolinium–ethoxybenzyl–diethylenetriamine pentaacetic acid-enhanced magnetic resonance imaging revealed a hypovascular liver tumor that was suspected to be metastatic. Upper gastrointestinal endoscopy revealed two suspected metastatic gastric tumors. Liver and gastric tumor biopsies revealed poor carcinoma in both. The patient’s condition gradually worsened and she died on day 8 of the illness. Based on autopsy findings, the patient was finally diagnosed with metastatic gastric and renal tumors originating from HCC. Additionally, a metastatic pancreatic tumor originating from the HCC was identified during autopsy. The pathological diagnosis of the pulmonary lesion was primary lung adenocarcinoma. In conclusion, HCC should be suspected in cases with multiple metastases of unknown primary lesions.
Bibliography:	ObjectType-Case Study-2 SourceType-Scholarly Journals-1 ObjectType-Review-5 ObjectType-Feature-4 content type line 23 ObjectType-Report-1 ObjectType-Article-3
ISSN:	1865-7257 1865-7265 1865-7265
DOI:	10.1007/s12328-024-01935-w