Search Results - "Unzeta, M."

Protective effect of the multitarget compound DPH‐4 on human SSAO/VAP‐1‐expressing hCMEC/D3 cells under oxygen–glucose deprivation conditions: an in vitro experimental model of cerebral ischaemia by Sun, P, Esteban, G, Inokuchi, T, Marco‐Contelles, J, Weksler, B B, Romero, I A, Couraud, P O, Unzeta, M, Solé, M

“…Background and Purpose Stroke and Alzheimer's disease (AD) are related pathologies in which the cerebrovascular system is involved. Plasma levels of…”
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Semicarbazide-sensitive amine oxidase (SSAO) and its possible contribution to vascular damage in Alzheimer's disease by Unzeta, M, Solé, M, Boada, M, Hernández, M

“…One of the key pathological features of the progressive neurodegenerative disorder Alzheimer's disease (AD) is cerebral amyloid angiopathy (CAA). CAA is…”
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The central histamine level in rat model of vascular dementia by Stasiak, A, Mussur, M, Unzeta, M, Lazewska, D, Kiec-Kononowicz, K, Fogel, W A

“…The histaminergic system plays an important role in memory and learning. Deficient histaminergic transmission in the human brain in vascular dementia (VD) has…”
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Variations in activity and inhibition with pH: the protonated amine is the substrate for monoamine oxidase, but uncharged inhibitors bind better by Jones, T Z E, Balsa, D, Unzeta, M, Ramsay, R R

“…It has been accepted that, as required mechanistically, the neutral form of the amine is the substrate for monoamine oxidase, despite the amine pK (a) of above…”
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Overexpression of semicarbazide sensitive amine oxidase in the cerebral blood vessels in patients with Alzheimer’s disease and cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy by Ferrer, I., Lizcano, J.M., Hernández, M., Unzeta, M.

“…Semicarbazide sensitive amine oxidase (SSAO) metabolizes oxidative deamination of primary aromatic and aliphatic amines, and, in the brain, it is selectively…”
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Protective effect of N-(2-propynyl)-2-(5-benzyloxy-indolyl) methylamine (PF9601N) on mitochondrial permeability transition by Battaglia, V, Sanz, E, Salvi, M, Unzeta, M, Toninello, A

“…PF9601N, N-(2-propynyl)-2-(5-benzyloxy-indolyl) methylamine, an monoamine oxidase (MAO) B inhibitor, has shown neuroprotective properties against dopaminergic…”
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Characterization of A7r5 cell line transfected in a stable form by hSSAO/VAP-1 gene (A7r5 hSSAO/VAP-1 cell line) by Solé, M, Hernandez, M, Boada, M, Unzeta, M

“…A smooth muscle cell line (A7r5) was stably transfected with the human SSAO/VAP-1 (hSSAO/VAP-1) gene. The expressed protein was located solely in the membrane…”
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The decrease of NAD(P)H has a prominent role in dopamine toxicity by Giménez-Xavier, P., Gómez-Santos, C., Castaño, E., Francisco, R., Boada, J., Unzeta, M., Sanz, E., Ambrosio, S.

“…We characterized dopamine toxicity in human neuroblastoma SH-SY5Y cells as a direct effect of dopamine on cell reductive power, measured as NADH and NADPH cell…”
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Prolonged treatment with aminoguanidine strongly inhibits adipocyte semicarbazide-sensitive amine oxidase and slightly reduces fat deposition in obese Zucker rats by Prévot, D., Soltesz, Z., Abello, V., Wanecq, E., Valet, P., Unzeta, M., Carpéné, C.

“…Beneficial effects of aminoguanidine (AG) on diabetic vascular complications result from prevention of protein glycation, inhibition of inductible NO synthase,…”
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Tissue Activity and Cellular Localization of Human Semicarbazide-sensitive Amine Oxidase by Andrés, Noemí, Lizcano, José Miguel, Rodríguez, Manuel J., Romera, Manuel, Unzeta, Mercedes, Mahy, Nicole

“…SUMMARY Semicarbazide-sensitive amine oxidase (SSAO), widely distributed in highly vascularized mammalian tissues, metabolizes endogenous and xenobiotic…”
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Activation of human lung semicarbazide sensitive amine oxidase by a low molecular weight component present in human plasma by Dalfó, E., Hernandez, M., Lizcano, J.M., Tipton, K.F., Unzeta, M.

“…Semicarbazide-sensitive amine oxidase (SSAO) encodes a wide family of enzymes named E.C.1.4.3.6 [amine:oxygen oxidoreductase (deaminating) (copper containing)]…”
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Protective effect of N-(2-propynyl)-2-(5-benzyloxy-indolyl) methylamine (PF 9601N), a novel MAO-B inhibitor, on dopamine-lesioned PC12 cultured cells by Perez, V., Romera, M., Lizcano, J. M., Marco, J. L., Unzeta, M.

“…Oxidative stress may play a role in the pathogenesis of Parkinson's disease. We have standardised a new model of dopaminergic‐cell toxicity that uses dopamine,…”
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The novel type B MAO inhibitor PF9601N enhances the duration of L-DOPA-induced contralateral turning in 6-hydroxydopamine lesioned rats by PRAT, G, PEREZ, V, RUBIO, A, CASAS, M, UNZETA, M

“…The present study examined the effect of the highly potent and selective MAO B inhibitor PF9601N on L-DOPA-induced rotational behavior in unilateral…”
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Time-dependent activation of the semicarbazide-sensitive amine oxidase (SSAO) from ox lung microsomes by Lizcano, J M, Tipton, K F, Unzeta, M

“…The activity of ox lung microsomal semicarbazide-sensitive amine oxidase (EC 1.4.3.6; SSAO) towards benzylamine increased 20-fold during incubation at 37…”
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Localization of monoamine oxidase A and B and semicarbazide-sensitive amine oxidase in human peripheral tissues by Ramonet, D, Rodríguez, M, Saura, J, Lizcano, J M, Romera, M, Unzeta, M, Finch, C, Billett, E, Mahy, N

“…Monoamine oxidase (MAO) A and B and semicarbazide-sensitive amine oxidase (SSAO) localizations in peripheral human tissues were compared by…”
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Some properties of semicarbazide-sensitive amine oxidase (SSAO) from human cerebrovascular tissues by Smeraldi, C, Castillo, V, Lizcano, J M, Unzeta, M

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On the primary structure of membrane-bound semicarbazide-sensitive amine oxidase (SSAO) by Lizcano, J M, Unzeta, M

“…Mammalian semicarbazide-sensitive amine oxidase (SSAO) activities are a diverse group of copper dependent enzymes within the classification EC 1.4.3.6…”
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Inhibition of monoamine oxidase A and B activities by imidazol(ine)/guanidine drugs, nature of the interaction and distinction from I 2 ‐imidazoline receptors in rat liver by Ozaita, Andrés, Olmos, Gabriel, Assumpció Boronat, M, Miguel Lizcano, José, Unzeta, Mercedes, García‐Sevilla, Jesús A

“…I 2 ‐Imidazoline sites ([ 3 H]‐idazoxan binding) have been identified on monoamine oxidase (MAO) and proposed to modulate the activity of the enzyme through an…”
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Sex-related effects of 1-methyl-4-phenyl-1,2,3,6-tetrahydro-pyridine treatment may be related to differences in monoamine oxidase B by Unzeta, M, Baron, S, Perez, V, Ambrosio, S, Mahy, N

“…Effects of the parkinsonism inducing neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) on striatal dopamine metabolism and the influence of sex on…”
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Presence of SSAO in human and bovine meninges and microvessels by Castillo, V, Lizcano, J M, Unzeta, M

“…In spite that SSAO enzyme is widely distributed in almost all tissues, specially in vascularized ones, its presence in brain microvessels is still controversy…”
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