Search Results - "Unschuld, Paul G."

Huntington disease: natural history, biomarkers and prospects for therapeutics by Ross, Christopher A., Aylward, Elizabeth H., Wild, Edward J., Langbehn, Douglas R., Long, Jeffrey D., Warner, John H., Scahill, Rachael I., Leavitt, Blair R., Stout, Julie C., Paulsen, Jane S., Reilmann, Ralf, Unschuld, Paul G., Wexler, Alice, Margolis, Russell L., Tabrizi, Sarah J.

“…Key Points No disease-modifying treatments are currently available for Huntington disease (HD), but clinical trials of potential compounds are imminent;…”
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Progressive cervical cord atrophy parallels cognitive decline in Alzheimer’s disease by Emmenegger, Tim M., Seiler, Raoul, Unschuld, Paul G., Freund, Patrick, Klohs, Jan

“…Alzheimer’s disease (AD) is characterized by progressive episodic memory dysfunction. A prominent hallmark of AD is gradual brain atrophy. Despite extensive…”
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Polymorphisms in the FKBP5 gene region modulate recovery from psychosocial stress in healthy controls by Ising, Marcus, Depping, Anna-Mareike, Siebertz, Anna, Lucae, Susanne, Unschuld, Paul G., Kloiber, Stefan, Horstmann, Sonja, Uhr, Manfred, Müller-Myhsok, Bertram, Holsboer, Florian

“…Mood and anxiety disorders are considered stress‐related diseases characterized by an impaired function of mineralocorticoid and glucocorticoid receptors (MR…”
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The A/T/N model applied through imaging biomarkers in a memory clinic by Dodich, Alessandra, Mendes, Aline, Assal, Frédéric, Chicherio, Christian, Rakotomiaramanana, Barinjaka, Andryszak, Paulina, Festari, Cristina, Ribaldi, Federica, Scheffler, Max, Schibli, Roger, Schwarz, Adam J., Zekry, Dina, Lövblad, Karl-Olof, Boccardi, Marina, Unschuld, Paul G., Gold, Gabriel, Frisoni, Giovanni B., Garibotto, Valentina

“…Purpose The A/T/N model is a research framework proposed to investigate Alzheimer’s disease (AD) pathological bases (i.e., amyloidosis A, neurofibrillary…”
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Physical activity is associated with lower cerebral beta-amyloid and cognitive function benefits from lifetime experience-a study in exceptional aging by Treyer, Valerie, Meyer, Rafael S, Buchmann, Andreas, Crameri, Giovanni A G, Studer, Sandro, Saake, Antje, Gruber, Esmeralda, Unschuld, Paul G, Nitsch, Roger M, Hock, Christoph, Gietl, Anton F

“…Exceptional agers (85+ years) are characterized by preserved cognition presumably due to high cognitive reserve. In the current study, we examined whether…”
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Functional network centrality indicates interactions between APOE4 and age across the clinical spectrum of Alzheimer’s Disease by Fall, Aïda B., Preti, Maria Giulia, Eshmawey, Mohamed, Kagerer, Sonja M., Van De Ville, Dimitri, Unschuld, Paul G.

“…•Distinct FC patterns characterize APOE4 carriers across clinical stages of AD.•Graph theory-based network centrality identifies brain connectivity linked to…”
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Changes of Functional and Directed Resting-State Connectivity Are Associated with Neuronal Oscillations, ApoE Genotype and Amyloid Deposition in Mild Cognitive Impairment by Michels, Lars, Muthuraman, Muthuraman, Anwar, Abdul R, Kollias, Spyros, Leh, Sandra E, Riese, Florian, Unschuld, Paul G, Siniatchkin, Michael, Gietl, Anton F, Hock, Christoph

“…The assessment of effects associated with cognitive impairment using electroencephalography (EEG) power mapping allows the visualization of frequency-band…”
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EEG-fMRI Signal Coupling Is Modulated in Subjects With Mild Cognitive Impairment and Amyloid Deposition by Michels, Lars, Riese, Florian, Meyer, Rafael, Kälin, Andrea M, Leh, Sandra E, Unschuld, Paul G, Luechinger, Roger, Hock, Christoph, O'Gorman, Ruth, Kollias, Spyros, Gietl, Anton

“…Cognitive impairment indicates disturbed brain physiology which can be due to various mechanisms including Alzheimer's pathology. Combined functional magnetic…”
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Gray matter gamma‐hydroxy‐butyric acid and glutamate reflect beta‐amyloid burden at old age by Schreiner, Simon J., Van Bergen, Jiri M. G., Gietl, Anton F., Buck, Alfred, Hock, Christoph, Pruessmann, Klaas P., Henning, Anke, Unschuld, Paul G.

“…Gamma‐hydroxy‐butyric acid (GABA) and glutamate are neurotransmitters with essential importance for cognitive processing. Here, we investigate relationships…”
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Functional Brain Network Connectivity Patterns Associated With Normal Cognition at Old-Age, Local β-amyloid, Tau, and APOE4 by Quevenco, Frances C, van Bergen, Jiri M, Treyer, Valerie, Studer, Sandro T, Kagerer, Sonja M, Meyer, Rafael, Gietl, Anton F, Kaufmann, Philipp A, Nitsch, Roger M, Hock, Christoph, Unschuld, Paul G

“…: Integrity of functional brain networks is closely associated with maintained cognitive performance at old age. Consistently, both carrier status of…”
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Subcortical Shape Changes, Hippocampal Atrophy and Cortical Thinning in Future Alzheimer's Disease Patients by Kälin, Andrea M, Park, Min T M, Chakravarty, M Mallar, Lerch, Jason P, Michels, Lars, Schroeder, Clemens, Broicher, Sarah D, Kollias, Spyros, Nitsch, Roger M, Gietl, Anton F, Unschuld, Paul G, Hock, Christoph, Leh, Sandra E

“…Efficacy of future treatments depends on biomarkers identifying patients with mild cognitive impairment at highest risk for transitioning to Alzheimer's…”
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Low Subicular Volume as an Indicator of Dementia-Risk Susceptibility in Old Age by Kagerer, Sonja M, Schroeder, Clemens, van Bergen, Jiri M G, Schreiner, Simon J, Meyer, Rafael, Steininger, Stefanie C, Vionnet, Laetitia, Gietl, Anton F, Treyer, Valerie, Buck, Alfred, Pruessmann, Klaas P, Hock, Christoph, Unschuld, Paul G

“…Hippocampal atrophy is an established Alzheimer's Disease (AD) biomarker. Volume loss in specific subregions as measurable with ultra-high field magnetic…”
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Polygenic risk for Alzheimer's disease is associated with neuroaxonal damage before onset of clinical symptoms by Kagerer, Sonja M., Awasthi, Swapnil, Ripke, Stephan, Maceski, Aleksandra, Benkert, Pascal, Fall, Aïda B., Riederer, Peter, Fischer, Peter, Walitza, Susanne, Grünblatt, Edna, Kuhle, Jens, Unschuld, Paul G.

“…INTRODUCTION Establishing valid diagnostic strategies is a precondition for successful therapeutic intervention in Alzheimer's disease (AD). METHODS One…”
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Reduced uptake of [11C]‐ABP688, a PET tracer for metabolic glutamate receptor 5 in hippocampus and amygdala in Alzheimer’s dementia by Treyer, Valerie, Gietl, Anton F., Suliman, Husam, Gruber, Esmeralda, Meyer, Rafael, Buchmann, Andreas, Johayem, Anass, Unschuld, Paul G., Nitsch, Roger M., Buck, Alfred, Ametamey, Simon M., Hock, Christoph

“…Introduction Metabotropic glutamate receptors play a critical role in the pathogenesis of Alzheimer's disease due to their involvement in processes of memory…”
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APOE4 moderates effects of cortical iron on synchronized default mode network activity in cognitively healthy old‐aged adults by Kagerer, Sonja M., Bergen, Jiri M. G., Li, Xu, Quevenco, Frances C., Gietl, Anton F., Studer, Sandro, Treyer, Valerie, Meyer, Rafael, Kaufmann, Philipp A., Nitsch, Roger M., Zijl, Peter C. M., Hock, Christoph, Unschuld, Paul G.

“…Introduction Apolipoprotein E ε4 (APOE4)–related genetic risk for sporadic Alzheimer's disease is associated with an early impairment of cognitive brain…”
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Fingerprints of brain disease: connectome identifiability in Alzheimer’s disease by Stampacchia, Sara, Asadi, Saina, Tomczyk, Szymon, Ribaldi, Federica, Scheffler, Max, Lövblad, Karl-Olof, Pievani, Michela, Fall, Aïda B., Preti, Maria Giulia, Unschuld, Paul G., Van De Ville, Dimitri, Blanke, Olaf, Frisoni, Giovanni B., Garibotto, Valentina, Amico, Enrico

“…Functional connectivity patterns in the human brain, like the friction ridges of a fingerprint, can uniquely identify individuals. Does this “brain…”
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Memory performance-related dynamic brain connectivity indicates pathological burden and genetic risk for Alzheimer's disease by Quevenco, Frances C, Preti, Maria G, van Bergen, Jiri M G, Hua, Jun, Wyss, Michael, Li, Xu, Schreiner, Simon J, Steininger, Stefanie C, Meyer, Rafael, Meier, Irene B, Brickman, Adam M, Leh, Sandra E, Gietl, Anton F, Buck, Alfred, Nitsch, Roger M, Pruessmann, Klaas P, van Zijl, Peter C M, Hock, Christoph, Van De Ville, Dimitri, Unschuld, Paul G

“…The incidence of Alzheimer's disease (AD) strongly relates to advanced age and progressive deposition of cerebral amyloid-beta (Aβ), hyperphosphorylated tau,…”
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Combined effects of exonic polymorphisms in CRHR1 and AVPR1B genes in a case/control study for panic disorder by Keck, Martin E., Kern, Nikola, Erhardt, Angelika, Unschuld, Paul G., Ising, Marcus, Salyakina, Daria, Müller, Marianne B., Knorr, Carolin C., Lieb, Roselind, Hohoff, Christa, Krakowitzky, Petra, Maier, Wolfgang, Bandelow, Borwin, Fritze, Jürgen, Deckert, Jürgen, Holsboer, Florian, Müller-Myhsok, Bertram, Binder, Elisabeth B.

“…Accumulating evidence from animal studies suggests that the corticotropin releasing hormone (CRH) and arginine vasopressin (AVP) neuropeptide systems,…”
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Brain areas with normatively greater cerebral perfusion in early life may be more susceptible to beta amyloid deposition in late life by Meier, Irene B., Lao, Patrick J., Gietl, Anton, Vorburger, Robert S., Gutierrez, José, Holland, Christopher M., Guttmann, Charles R.G., Meier, Dominik S., Buck, Alfred, Nitsch, Roger M., Hock, Christoph, Unschuld, Paul G., Brickman, Adam M.

“…•Brain areas with higher neuronal activity and metabolic demand in early life may contribute to higher beta amyloid deposition later in life.•The spatial…”
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Recent advances in cerebrospinal fluid biomarkers for the detection of preclinical Alzheimer's disease by Kulic, Luka, Unschuld, Paul G

“…The concept of preclinical Alzheimer's disease has emerged to describe the long 'silent' phase of the disease when significant pathophysiological changes occur…”
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