Search Results - "Uno, Brice E"

Amphotericin primarily kills yeast by simply binding ergosterol by Gray, Kaitlyn C., Palacios, Daniel S., Dailey, Ian, Endo, Matthew M., Uno, Brice E., Wilcock, Brandon C., Burke, Martin D.

“…Amphotericin B (AmB) is a prototypical small molecule natural product that can form ion channels in living eukaryotic cells and has remained refractory to…”
Get full text

Amphotericin forms an extramembranous and fungicidal sterol sponge by Anderson, Thomas M, Clay, Mary C, Cioffi, Alexander G, Diaz, Katrina A, Hisao, Grant S, Tuttle, Marcus D, Nieuwkoop, Andrew J, Comellas, Gemma, Maryum, Nashrah, Wang, Shu, Uno, Brice E, Wildeman, Erin L, Gonen, Tamir, Rienstra, Chad M, Burke, Martin D

“…NMR structural data and biophysical and biological experiments show that the antifungal compound amphotericin is toxic because it acts as a sterol sponge by…”
Get full text

Combined Effects of Carbonate and Soft-Segment Molecular Structures on the Nanophase Separation and Properties of Segmented Polyhydroxyurethane by Beniah, Goliath, Chen, Xi, Uno, Brice E, Liu, Kun, Leitsch, Emily K, Jeon, Junho, Heath, William H, Scheidt, Karl A, Torkelson, John M

“…The influence of hard-segment structure on the properties of segmented polyhydroxy­urethane (PHU) was investigated using three bis-carbonate molecules:…”
Get full text

Tuning nanophase separation behavior in segmented polyhydroxyurethane via judicious choice of soft segment by Beniah, Goliath, Uno, Brice E., Lan, Tian, Jeon, Junho, Heath, William H., Scheidt, Karl A., Torkelson, John M.

“…Polyhydroxyurethane (PHU) is of major research interest because it is a non-isocyanate polyurethane-like (NIPU) polymer. Here, we demonstrate the ability to…”
Get full text

C2′-OH of Amphotericin B Plays an Important Role in Binding the Primary Sterol of Human Cells but Not Yeast Cells by Wilcock, Brandon C, Endo, Matthew M, Uno, Brice E, Burke, Martin D

“…Amphotericin B (AmB) is a clinically vital antimycotic but is limited by its severe toxicity. Binding ergosterol, independent of channel formation, is the…”
Get full text

Tuning sterol extraction kinetics yields a renal-sparing polyene antifungal by Maji, Arun, Soutar, Corinne P., Zhang, Jiabao, Lewandowska, Agnieszka, Uno, Brice E., Yan, Su, Shelke, Yogesh, Murhade, Ganesh, Nimerovsky, Evgeny, Borcik, Collin G., Arango, Andres S., Lange, Justin D., Marin-Toledo, Jonnathan P., Lyu, Yinghuan, Bailey, Keith L., Roady, Patrick J., Holler, Jordan T., Khandelwal, Anuj, SantaMaria, Anna M., Sanchez, Hiram, Juvvadi, Praveen R., Johns, Gina, Hageman, Michael J., Krise, Joanna, Gebremariam, Teclegiorgis, Youssef, Eman G., Bartizal, Ken, Marr, Kieren A., Steinbach, William J., Ibrahim, Ashraf S., Patterson, Thomas F., Wiederhold, Nathan P., Andes, David R., Pogorelov, Taras V., Schwieters, Charles D., Fan, Timothy M., Rienstra, Chad M., Burke, Martin D.

“…Decades of previous efforts to develop renal-sparing polyene antifungals were misguided by the classic membrane permeabilization model 1 . Recently, the…”
Get full text

Conjugate Additions of Amines to Maleimides via Cooperative Catalysis by Uno, Brice E., Deibler, Kristine K., Villa, Carlos, Raghuraman, Arjun, Scheidt, Karl A.

“…A cooperative system comprising of a lithium Lewis acid and amine base significantly enhances the rate of the conjugate addition of a wide array of amines to…”
Get full text

Vinyl MIDA boronate: a readily accessible and highly versatile building block for small molecule synthesis by Uno, Brice E., Gillis, Eric P., Burke, Martin D.

Get full text

Prodrug Strategies to Improve the Solubility of the HCV NS5A Inhibitor Pibrentasvir (ABT-530) by Randolph, John T, Voight, Eric A, Greszler, Stephen N, Uno, Brice E, Newton, James N, Gleason, Kenneth M, Stolarik, DeAnne, Van Handel, Cecilia, Bow, Daniel A. J, DeGoey, David A

“…A research program to discover solubilizing prodrugs of the HCV NS5A inhibitor pibrentasvir (PIB) identified phosphomethyl analog 2 and trimethyl-lock (TML)…”
Get full text

Calcium(ii)-catalyzed enantioselective conjugate additions of amines by Uno, Brice E, Dicken, Rachel D, Redfern, Louis R, Stern, Charlotte M, Krzywicki, Greg G, Scheidt, Karl A

“…The direct enantioselective chiral calcium(ii)·phosphate complex (Ca[CPA] )-catalyzed conjugate addition of unprotected alkyl amines to maleimides was…”
Get full text

Electronic tuning of site-selectivity by Wilcock, Brandon C., Uno, Brice E., Bromann, Gretchen L., Clark, Matthew J., Anderson, Thomas M., Burke, Martin D.

“…Site-selective functionalizations of complex small molecules can generate targeted derivatives with exceptional step efficiency, but general strategies for…”
Get full text

Calcium(ii)-catalyzed enantioselective conjugate additions of aminesWe thank Dow Chemical Company for generous support of this work.Electronic supplementary information (ESI) available: Experimental procedures, characterization of new compounds, and spectroscopic data. CCDC 1531303, 1531265. For ESI and crystallographic data in CIF or other electronic format see DOI: 10.1039/c7sc05205g by Uno, Brice E, Dicken, Rachel D, Redfern, Louis R, Stern, Charlotte M, Krzywicki, Greg G, Scheidt, Karl A

“…The direct enantioselective chiral calcium( ii )·phosphate complex (Ca[CPA] 2 )-catalyzed conjugate addition of unprotected alkyl amines to maleimides was…”
Get full text

Calcium(ii)-catalyzed enantioselective conjugate additions of amines† †We thank Dow Chemical Company for generous support of this work. ‡ ‡Electronic supplementary information (ESI) available: Experimental procedures, characterization of new compounds, and spectroscopic data. CCDC 1531303, 1531265. For ESI and crystallographic data in CIF or other electronic format see DOI: 10.1039/c7sc05205g by Uno, Brice E., Dicken, Rachel D., Redfern, Louis R., Stern, Charlotte M., Krzywicki, Greg G., Scheidt, Karl A.

“…The direct enantioselective chiral calcium( ii )·phosphate complex (Ca[CPA] 2 )-catalyzed conjugate addition of unprotected alkyl amines to maleimides was…”
Get full text

The C2′–OH of Amphotericin B Plays an Important Role in Binding the Primary Sterol of Human But Not Yeast Cells by Wilcock, Brandon C., Endo, Matthew M., Uno, Brice E., Burke, Martin D.

“…Amphotericin B (AmB) is a clinically vital anti-mycotic but is limited by its severe toxicity. Binding ergosterol, independent of channel formation, is the…”
Get full text

Vinyl MIDA boronate : a readily accessible and highly versatile building block for small molecule synthesis: Recent Advances in Synthetic Methodology: Development and Applications by UNO, Brice E, GILLIS, Eric P, BURKE, Martin D

Get full text