Biocompatibility evaluation of nano-hydroxyapatite modified hydroxypropyl methylcellulose/polyvinylpyrrolidone blends

Blending of polymers can be utilized to improve the properties of the new hybrid system without sacrificing the individual characteristics of the components. A combination of biocompatible cellulose-based polymer, hydroxypropyl methylcellulose (HPMC) and synthetic biocompatible polymer polyvinyl pyr...

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Bibliographic Details
Published in:	Polymer bulletin (Berlin, Germany) Vol. 81; no. 4; pp. 3439 - 3458
Main Authors:	Unni, Archa, Mathew, Mekha Mariam, Manathanath, Monisha, Jacob, Sunil, Sankaranarayanan, Pooja, Vasu, Suchithra Tharamel, Panicker, Unnikrishnan Gopalakrishna
Format:	Journal Article
Language:	English
Published:	Berlin/Heidelberg Springer Berlin Heidelberg 01-02-2024
Subjects:	Characterization and Evaluation of Materials Chemistry Chemistry and Materials Science Complex Fluids and Microfluidics Organic Chemistry Original Paper Physical Chemistry Polymer Sciences Soft and Granular Matter Biocompatibility Blends Hydroxypropyl methylcellulose Nano-hydroxyapatite Biopolymer
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Summary:	Blending of polymers can be utilized to improve the properties of the new hybrid system without sacrificing the individual characteristics of the components. A combination of biocompatible cellulose-based polymer, hydroxypropyl methylcellulose (HPMC) and synthetic biocompatible polymer polyvinyl pyrrolidone (PVP) has been designed to modify the mechanical and thermal properties via blending strategy. This work investigates the modification of HPMC and PVP blends through plasticizing with polyethylene glycol (PEG 6000, a non-toxic plasticizer to improve the flexibility of the matrix. The optimized blend system has been embedding with nHA as a biocompatible multifunctional filler to reinforce the polymer matrix for improving the efficacy in biomedical applications. The characterization has been extended through the evaluation of FTIR, XRD, TGA, DSC, SEM and UV-Visible spectroscopy. The reinforced blend has been found to match the requirements for fabricating wound healing patches in the biosector.
ISSN:	0170-0839 1436-2449
DOI:	10.1007/s00289-023-04870-x