Search Results - "Ungerstedt, Johanna"

Epigenetic Modifiers in Myeloid Malignancies: The Role of Histone Deacetylase Inhibitors by Ungerstedt, Johanna S

“…Myeloid hematological malignancies are clonal bone marrow neoplasms, comprising of acute myeloid leukemia (AML), the myelodysplastic syndromes (MDS), chronic…”
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KIT signaling is dispensable for human mast cell progenitor development by Dahlin, Joakim S., Ekoff, Maria, Grootens, Jennine, Löf, Liza, Amini, Rose-Marie, Hagberg, Hans, Ungerstedt, Johanna S., Olsson-Strömberg, Ulla, Nilsson, Gunnar

“…Human hematopoietic progenitors are generally assumed to require stem cell factor (SCF) and KIT signaling during differentiation for the formation of mast…”
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Omalizumab alleviates pruritus in myeloproliferative neoplasms by Ravn Landtblom, Anna, Ungerstedt, Johanna, Hedlund, Anette, Tobiasson, Magnus, Deneberg, Stefan, Jädersten, Martin

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The functional and molecular impact of triamcinolone acetonide on primary human bone marrow mesenchymal stem cells by Kumlin, Maritha, Ungerstedt, Johanna, Cai, Huan, Leonard, Elory, Felländer-Tsai, Li, Qian, Hong

“…Traumatic or degenerative joint pain is abundant in the population. Symptom relief by intra- and periarticular glucocorticoid administration is frequently…”
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Activation of a Subset of Evolutionarily Young Transposable Elements and Innate Immunity Are Linked to Clinical Responses to 5-Azacytidine by Ohtani, Hitoshi, Ørskov, Andreas D, Helbo, Alexandra S, Gillberg, Linn, Liu, Minmin, Zhou, Wanding, Ungerstedt, Johanna, Hellström-Lindberg, Eva, Sun, Weili, Liang, Gangning, Jones, Peter A, Grønbæk, Kirsten

“…The DNA methyltransferase inhibitors (DNMTi) 5-azacytidine and 5-aza-2-deoxycytidine have been approved for the treatment of different types of hematologic…”
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Co-mutation pattern, clonal hierarchy, and clone size concur to determine disease phenotype of SRSF2P95-mutated neoplasms by Todisco, Gabriele, Creignou, Maria, Gallì, Anna, Guglielmelli, Paola, Rumi, Elisa, Roncador, Marco, Rizzo, Ettore, Nannya, Yasuhito, Pietra, Daniela, Elena, Chiara, Bono, Elisa, Molteni, Elisabetta, Rosti, Vittorio, Catricalá, Silvia, Sarchi, Martina, Dimitriou, Marios, Ungerstedt, Johanna, Vannucchi, Alessandro Maria, Hellström-Lindberg, Eva, Ogawa, Seishi, Cazzola, Mario, Malcovati, Luca

“…Somatic mutations in splicing factor genes frequently occur in myeloid neoplasms. While SF3B1 mutations are associated with myelodysplastic syndromes (MDS)…”
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CD203c distinguishes the erythroid and mast cell‐basophil differentiation trajectories among human FcεRI+ bone marrow progenitors by Grootens, Jennine, Ungerstedt, Johanna S., Wu, Chenyan, Hamberg Levedahl, Kerstin, Nilsson, Gunnar, Dahlin, Joakim S.

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Deciphering the differentiation trajectory from hematopoietic stem cells to mast cells by Grootens, Jennine, Ungerstedt, Johanna S., Nilsson, Gunnar, Dahlin, Joakim S.

“…Hematopoietic stem cells differentiate into all types of blood cells, including peripheral tissue-resident mast cells. The early mast cell differentiation…”
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Motexafin Gadolinium, a Tumor-selective Drug Targeting Thioredoxin Reductase and Ribonucleotide Reductase by Hashemy, Seyed Isaac, Ungerstedt, Johanna S., Avval, Farnaz Zahedi, Holmgren, Arne

“…Motexafin gadolinium (MGd) is a chemotherapeutic drug that selectively targets tumor cells and mediates redox reactions generating reactive oxygen species…”
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Localization-Specific Expression of CCR1 and CCR5 by Mast Cell Progenitors by Salomonsson, Maya, Dahlin, Joakim S, Ungerstedt, Johanna, Hallgren, Jenny

“…Mast cells are powerful immune cells found predominately in barrier tissues. They play an important role in immune surveillance and act as effector cells in…”
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Myelodysplastic syndromes by Ungerstedt, Johanna

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Genome-wide profiling of histone H3 lysine 27 and lysine 4 trimethylation in multiple myeloma reveals the importance of Polycomb gene targeting and highlights EZH2 as a potential therapeutic target by Agarwal, Prasoon, Alzrigat, Mohammad, Párraga, Alba Atienza, Enroth, Stefan, Singh, Umashankar, Ungerstedt, Johanna, Österborg, Anders, Brown, Peter J, Ma, Anqi, Jin, Jian, Nilsson, Kenneth, Öberg, Fredrik, Kalushkova, Antonia, Jernberg-Wiklund, Helena

“…Multiple myeloma (MM) is a malignancy of the antibody-producing plasma cells. MM is a highly heterogeneous disease, which has hampered the identification of a…”
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Single-cell transcriptomics reveals the identity and regulators of human mast cell progenitors by Wu, Chenyan, Boey, Daryl, Bril, Oscar, Grootens, Jennine, Vijayabaskar, M.S., Sorini, Chiara, Ekoff, Maria, Wilson, Nicola K., Ungerstedt, Johanna S., Nilsson, Gunnar, Dahlin, Joakim S.

“…Mast cell accumulation is a hallmark of a number of diseases, including allergic asthma and systemic mastocytosis. Immunoglobulin E–mediated crosslinking of…”
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Single-cell analysis reveals the KIT D816V mutation in haematopoietic stem and progenitor cells in systemic mastocytosis by Grootens, Jennine, Ungerstedt, Johanna S., Ekoff, Maria, Rönnberg, Elin, Klimkowska, Monika, Amini, Rose-Marie, Arock, Michel, Söderlund, Stina, Mattsson, Mattias, Nilsson, Gunnar, Dahlin, Joakim S.

“…Systemic mastocytosis (SM) is a haematological disease characterised by organ infiltration by neoplastic mast cells. Almost all SM patients have a mutation in…”
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Methylseleninic Acid Sensitizes Ovarian Cancer Cells to T-Cell Mediated Killing by Decreasing PDL1 and VEGF Levels by Nair, Deepika, Rådestad, Emelie, Khalkar, Prajakta, Diaz-Argelich, Nuria, Schröder, Axel, Klynning, Charlotte, Ungerstedt, Johanna, Uhlin, Michael, Fernandes, Aristi P

“…Redox active selenium (Se) compounds at sub toxic doses act as pro-oxidants with cytotoxic effects on tumor cells and are promising future chemotherapeutic…”
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P506: CLINICAL VALIDATION OF THE NORDIC GUIDELINES FOR GERMLINE TESTING IN MYELOID NEOPLASMS: RESULTS FROM A MULTI‐CENTER PROSPECTIVE COHORT STUDY by Tesi, Bianca, Eriksson, Anna, Baskin, Berivan, Lazarevic, Vladimir, Deneberg, Stefan, Höglund, Martin, Fogelstrand, Linda, Ungerstedt, Johanna, Pandzic, Tatjana, Tobiasson, Magnus, Gravdahl Garelius, Hege, Kuchinskaya, Ekaterina, Persson, Fredrik, Ågerstam, Helena, Uggla, Bertil, Hallböök, Helene, Fioretos, Thoas, Thuresson, Ann‐Charlotte, Lehmann, Sören, Ladenvall, Claes, Barbany, Gisela, Vennström, Lovisa, Ejerblad, Elisabeth, Cavelier, Lucia, Cammenga, Jörg, Jädersten, Martin, Hellström Lindberg, Eva, Baliakas, Panagiotis

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P1017: REDUCTIONS IN INDOLENT SYSTEMIC MASTOCYTOSIS BIOMARKER BURDEN WITH AVAPRITINIB IN THE REGISTRATIONAL, DOUBLE‐BLIND PLACEBO‐CONTROLLED PIONEER TRIAL by Gotlib, Jason, Castells, Mariana, Oude Elberink, Hanneke, Siebenhaar, Frank, Hartmann, Karin, Broesby‐Olsen, Sigurd, George, Tracy I., Panse, Jens, Alvarez‐Twose, Ivan, Radia, Deepti, Tashi, Tsewang, Bulai Livideanu, Cristina, Sabato, Vito, Van Daele, Paul, Cerquozzi, Sonia, Dybedal, Ingunn, Reiter, Andreas, Ustun, Celalettin, Schafhausen, Philippe, Bose, Prithviraj, Deangelo, Daniel J., Rein, Lindsay, Vachhani, Pankit, Triggiani, Massimo, Rafferty, Mark, Butt, Nauman, Oh, Stephen, Wortmann, Friederike, Ungerstedt, Johanna, Taparia, Minakshi, Kuykendall, Andrew T., Arana Yi, Cecilia, Mattsson, Mattias, Shomali, William, Giannetti, Matthew, Bidollari, Ilda, Lin, Hui‐Min, Scherber, Robyn, Roche, Maria, Akin, Cem, Maurer, Marcus

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Plasma glutaredoxin activity in healthy subjects and patients with abnormal glucose levels or overt type 2 diabetes by Du, Yatao, Zhang, Huihui, Montano, Sergio, Hegestam, Jesper, Ekberg, Neda Rajamand, Holmgren, Arne, Brismar, Kerstin, Ungerstedt, Johanna S.

“…Oxidative stress induced by hyperglycemia is a key factor in the pathogenesis of diabetes complications. Glutaredoxin 1(Grx1) is a cytosolic redox protein that…”
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Glutaredoxin mediated redox effects of coenzyme Q10 treatment in type 1 and type 2 diabetes patients by Montano, Sergio J., Grünler, Jacob, Nair, Deepika, Tekle, Michael, Fernandes, Aristi P., Hua, Xiang, Holmgren, Arne, Brismar, Kerstin, Ungerstedt, Johanna S.

“…The possible beneficial effects of coenzyme Q10 (CoQ10) supplementation on disease progression and oxidant status in diabetes remains debated. In the present…”
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Discrepancy between antithrombin activity methods revealed in Antithrombin Stockholm: do factor Xa–based methods overestimate antithrombin activity in some patients? by Ungerstedt, Johanna S., Schulman, Sam, Egberg, Nils, Antovic, Jovan, Blombäck, Margareta

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