Search Results - "Ungerleider, Nathan A"

BH3 mimetics selectively eliminate chemotherapy-induced senescent cells and improve response in TP53 wild-type breast cancer by Shahbandi, Ashkan, Rao, Sonia G., Anderson, Ashlyn Y., Frey, Wesley D., Olayiwola, Joy O., Ungerleider, Nathan A., Jackson, James G.

“…TP53 wild-type breast tumors rarely undergo a complete pathological response after chemotherapy treatment. These patients have an extremely poor survival rate…”
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Breast cancer survival predicted by TP53 mutation status differs markedly depending on treatment by Ungerleider, Nathan A, Rao, Sonia G, Shahbandi, Ashkan, Yee, Douglas, Niu, Tianhua, Frey, Wesley D, Jackson, James G

“…Previous studies on the role of TP53 mutation in breast cancer treatment response and survival are contradictory and inconclusive, limited by the use of…”
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SpliceTools, a suite of downstream RNA splicing analysis tools to investigate mechanisms and impact of alternative splicing by Flemington, Erik K, Flemington, Samuel A, O’Grady, Tina M, Baddoo, Melody, Nguyen, Trang, Dong, Yan, Ungerleider, Nathan A

“…Abstract As a fundamental aspect of normal cell signaling and disease states, there is great interest in determining alternative splicing (AS) changes in…”
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The nucleic acid binding protein SFPQ represses EBV lytic reactivation by promoting histone H1 expression by Murray-Nerger, Laura A., Lozano, Clarisel, Burton, Eric M., Liao, Yifei, Ungerleider, Nathan A., Guo, Rui, Gewurz, Benjamin E.

“…Epstein-Barr virus (EBV) uses a biphasic lifecycle of latency and lytic reactivation to infect >95% of adults worldwide. Despite its central role in EBV…”
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Gammaherpesvirus RNAs Come Full Circle by Ungerleider, Nathan A, Tibbetts, Scott A, Renne, Rolf, Flemington, Erik K

“…After an adaptive immune response is mounted, gammaherpesviruses achieve persistence through the utilization of viral noncoding RNAs to craft a suitable host…”
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Reversal of splicing infidelity is a pre-activation step in B cell differentiation by O'Grady, Tina M, Baddoo, Melody, Flemington, Samuel A, Ishaq, Eman Y, Ungerleider, Nathan A, Flemington, Erik K

“…B cell activation and differentiation is central to the adaptive immune response. Changes in exon usage can have major impacts on cellular signaling and…”
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Breast cancer cells survive chemotherapy by activating targetable immune-modulatory programs characterized by PD-L1 or CD80 by Shahbandi, Ashkan, Chiu, Fang-Yen, Ungerleider, Nathan A, Kvadas, Raegan, Mheidly, Zeinab, Sun, Meijuan J S, Tian, Di, Waizman, Daniel A, Anderson, Ashlyn Y, Machado, Heather L, Pursell, Zachary F, Rao, Sonia G, Jackson, James G

“…Breast cancer cells must avoid intrinsic and extrinsic cell death to relapse following chemotherapy. Entering senescence enables survival from mitotic…”
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p53 Mediates Vast Gene Expression Changes That Contribute to Poor Chemotherapeutic Response in a Mouse Model of Breast Cancer by Tonnessen-Murray, Crystal, Ungerleider, Nathan A., Rao, Sonia G., Wasylishen, Amanda R., Frey, Wesley D., Jackson, James G.

“…p53 is a transcription factor that regulates expression of genes involved in cell cycle arrest, senescence, and apoptosis. TP53 harbors mutations that…”
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Chemotherapy-induced senescent cancer cells engulf other cells to enhance their survival by Tonnessen-Murray, Crystal A, Frey, Wesley D, Rao, Sonia G, Shahbandi, Ashkan, Ungerleider, Nathan A, Olayiwola, Joy O, Murray, Lucas B, Vinson, Benjamin T, Chrisey, Douglas B, Lord, Christopher J, Jackson, James G

“…In chemotherapy-treated breast cancer, wild-type p53 preferentially induces senescence over apoptosis, resulting in a persisting cell population constituting…”
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Comparative Analysis of Gammaherpesvirus Circular RNA Repertoires: Conserved and Unique Viral Circular RNAs by Ungerleider, Nathan A, Jain, Vaibhav, Wang, Yiping, Maness, Nicholas J, Blair, Robert V, Alvarez, Xavier, Midkiff, Cecily, Kolson, Dennis, Bai, Shanshan, Roberts, Claire, Moss, Walter N, Wang, Xia, Serfecz, Jacqueline, Seddon, Michael, Lehman, Terri, Ma, Tianfang, Dong, Yan, Renne, Rolf, Tibbetts, Scott A, Flemington, Erik K

“…Recent studies have identified circular RNAs (circRNAs) expressed from the Epstein-Barr virus (EBV) and Kaposi's sarcoma herpesvirus (KSHV) human DNA tumor…”
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Viral reprogramming of host transcription initiation by Ungerleider, Nathan A, Roberts, Claire, O'Grady, Tina M, Nguyen, Trang T, Baddoo, Melody, Wang, Jia, Ishaq, Eman, Concha, Monica, Lam, Meggie, Bass, Jordan, Nguyen, Truong D, Van Otterloo, Nick, Wickramarachchige-Dona, Nadeeshika, Wyczechowska, Dorota, Morales, Maria, Ma, Tianfang, Dong, Yan, Flemington, Erik K

“…Viruses are master remodelers of the host cell environment in support of infection and virus production. For example, viruses typically regulate cell gene…”
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Cancers from Novel Pole -Mutant Mouse Models Provide Insights into Polymerase-Mediated Hypermutagenesis and Immune Checkpoint Blockade by Galati, Melissa A, Hodel, Karl P, Gams, Miki S, Sudhaman, Sumedha, Bridge, Taylor, Zahurancik, Walter J, Ungerleider, Nathan A, Park, Vivian S, Ercan, Ayse B, Joksimovic, Lazar, Siddiqui, Iram, Siddaway, Robert, Edwards, Melissa, de Borja, Richard, Elshaer, Dana, Chung, Jiil, Forster, Victoria J, Nunes, Nuno M, Aronson, Melyssa, Wang, Xia, Ramdas, Jagadeesh, Seeley, Andrea, Sarosiek, Tomasz, Dunn, Gavin P, Byrd, Jonathan N, Mordechai, Oz, Durno, Carol, Martin, Alberto, Shlien, Adam, Bouffet, Eric, Suo, Zucai, Jackson, James G, Hawkins, Cynthia E, Guidos, Cynthia J, Pursell, Zachary F, Tabori, Uri

“…mutations are a major cause of hypermutant cancers, yet questions remain regarding mechanisms of tumorigenesis, genotype-phenotype correlation, and therapeutic…”
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Ebola virus delta peptide is an enterotoxin by Melnik, Lilia I, Guha, Shantanu, Ghimire, Jenisha, Smither, Allison R, Beddingfield, Brandon J, Hoffmann, Andrew R, Sun, Leisheng, Ungerleider, Nathan A, Baddoo, Melody C, Flemington, Erik K, Gallaher, William R, Wimley, William C, Garry, Robert F

“…During the 2013-2016 West African (WA) Ebola virus (EBOV) outbreak, severe gastrointestinal symptoms were common in patients and associated with poor outcome…”
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Increased Activin Bioavailability Enhances Hepatic Insulin Sensitivity While Inducing Hepatic Steatosis in Male Mice by Ungerleider, Nathan A, Bonomi, Lara M, Brown, Melissa L, Schneyer, Alan L

“…The development of insulin resistance is tightly linked to fatty liver disease and is considered a major health concern worldwide, although their mechanistic…”
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Differential synthesis and action of TGFβ superfamily ligands in mouse and rat islets by Brown, Melissa L., Kimura, Fuminori, Bonomi, Lara M., Ungerleider, Nathan A., Schneyer, Alan L.

“…Members of the TGFβ superfamily, including activins and TGFβ, modulate glucose-stimulated insulin secretion (GSIS) in vitro using rat islets while genetic…”
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Abstract 1297: Chemotherapy-induced senescence activates robust, parallel programs of immune checkpoint expression that can be targeted with immunotherapy by Shahbandi, Ashkan, Chiu, Fang-Yen, Ungerleider, Nathan A., Anderson, Ashlyn Y., Machado, Heather L., Pursell, Zachary F., Kvadas, Raegan, Rao, Sonia G., Jackson, James G.

“…Abstract We and others have previously shown that the breast cancers most difficult to eradicate with chemotherapy are TP53 wild-type, and these are among the…”
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Breast cancer cells survive chemotherapy by activating targetable immune modulatory programs characterized by either PD-L1 or CD80 by Shahbandi, Ashkan, Chiu, Fang-Yen, Ungerleider, Nathan A., Kvadas, Raegan, Mheidly, Zeinab, Sun, Meijuan J S, Tian, Di, Waizman, Daniel A., Anderson, Ashlyn Y., Machado, Heather L., Pursell, Zachary F., Rao, Sonia G., Jackson, James G.

“…Breast cancer cells must avoid intrinsic and extrinsic cell death to relapse following chemotherapy. Entering senescence enables survival from mitotic…”
Get full text

p53 Mediates Vast Gene Expression Changes That Contribute to Poor Chemotherapeutic Response in a Mouse Model of Breast Cancer12 by Tonnessen-Murray, Crystal, Ungerleider, Nathan A., Rao, Sonia G., Wasylishen, Amanda R., Frey, Wesley D., Jackson, James G.

“…p53 is a transcription factor that regulates expression of genes involved in cell cycle arrest, senescence, and apoptosis. TP53 harbors mutations that…”
Get full text

Differential synthesis and action of TGFß superfamily ligands in mouse and rat islets by Brown, Melissa L, Kimura, Fuminori, Bonomi, Lara M, Ungerleider, Nathan A, Schneyer, Alan L

“…Members of the TGFß superfamily, including activins and TGFß, modulate glucose-stimulated insulin secretion (GSIS) in vitro using rat islets while genetic…”
Get full text