Search Results - "Unger, Wendy W.J."

Microbes and asthma: Opportunities for intervention by Smits, Hermelijn H., PhD, Hiemstra, Pieter S., PhD, Prazeres da Costa, Clarissa, MD, PhD, Ege, Markus, MPH, Edwards, Michael, PhD, Garn, Holger, PhD, Howarth, Peter H., MD, Jartti, Tuomas, MD, de Jong, Esther C., PhD, Maizels, Rick M., PhD, Marsland, Ben J., PhD, McSorley, Henry J., PhD, Müller, Anne, PhD, Pfefferle, Petra I., PhD, Savelkoul, Huub, PhD, Schwarze, Jürgen, MD, Unger, Wendy W.J., PhD, von Mutius, Erika, MD, MSc, Yazdanbakhsh, Maria, PhD, Taube, Christian, MD, PhD

“…The worldwide incidence and prevalence of asthma continues to increase. Asthma is now understood as an umbrella term for different phenotypes or endotypes,…”
Get full text

Induction of Treg by monocyte-derived DC modulated by vitamin D₃ or dexamethasone: Differential role for PD-L1 by Unger, Wendy W.J, Laban, Sandra, Kleijwegt, Fleur S, van der Slik, Arno R, Roep, Bart O

“…Specific therapy with modulated DC may restore immunological tolerance, thereby obviating the need for chronic immunosuppression in transplantation or…”
Get full text

Outer membrane vesicles engineered to express membrane-bound antigen program dendritic cells for cross-presentation to CD8+ T cells by Schetters, Sjoerd T.T., Jong, Wouter S.P., Horrevorts, Sophie K., Kruijssen, Laura J.W., Engels, Steef, Stolk, Dorian, Daleke-Schermerhorn, Maria H., Garcia-Vallejo, Juan, Houben, Diane, Unger, Wendy W.J., den Haan, Joke M.M., Luirink, Joen, van Kooyk, Yvette

“…[Display omitted] Outer membrane vesicles (OMVs) are vesicular nano-particles produced by Gram-negative bacteria that are recently being explored as vaccine…”
Get full text

Glycan-based DC-SIGN targeting vaccines to enhance antigen cross-presentation by van Kooyk, Yvette, Unger, Wendy W.J., Fehres, Cynthia M., Kalay, Hakan, García-Vallejo, Juan J.

“…► Leb and LeX glycans achieve an efficient antigen-targeting to DCs through DC-SIGN. ► Glycan multivalency is a necessary condition for efficient targeting. ►…”
Get full text

Understanding the biology of antigen cross-presentation for the design of vaccines against cancer by Fehres, Cynthia M, Unger, Wendy W J, Garcia-Vallejo, Juan J, van Kooyk, Yvette

“…Antigen cross-presentation, the process in which exogenous antigens are presented on MHC class I molecules, is crucial for the generation of effector CD8(+) T…”
Get full text

Things that could be Mycoplasma pneumoniae by de Groot, Ruben C.A, Meyer Sauteur, Patrick M, Unger, Wendy W.J, van Rossum, Annemarie M.C

“…Summary M. pneumoniae infection gives rise to a wide variety of manifestations. The pathogenesis of secondary manifestations is not always known. Some depend…”
Get full text

Intrathecal antibody responses to GalC in Guillain-Barré syndrome triggered by Mycoplasma pneumoniae by Meyer Sauteur, Patrick M., Huizinga, Ruth, Tio-Gillen, Anne P., Drenthen, Judith, Unger, Wendy W.J., Jacobs, Enno, van Rossum, Annemarie M.C., Jacobs, Bart C.

“…Mycoplasma pneumoniae (Mp) triggers Guillain-Barré syndrome (GBS) and elicits anti-galactocerebroside (GalC) antibodies. Specifically anti-GalC IgG is…”
Get full text

Lentiviral gene therapy prevents anti-human acid α-glucosidase antibody formation in murine Pompe disease by Liang, Qiushi, Vlaar, Eva C., Catalano, Fabio, Pijnenburg, Joon M., Stok, Merel, van Helsdingen, Yvette, Vulto, Arnold G., Unger, Wendy W.J., van der Ploeg, Ans T., Pijnappel, W.W.M. Pim, van Til, Niek P.

“…Enzyme replacement therapy (ERT) is the current standard treatment for Pompe disease, a lysosomal storage disorder caused by deficiency of the lysosomal enzyme…”
Get full text

DC-SIGN mediated antigen-targeting using glycan-modified liposomes: Formulation considerations by Joshi, Medha D., Unger, Wendy W.J., van Beelen, Astrid J., Bruijns, Sven C., Litjens, Manja, van Bloois, Louis, Kalay, Hakan, van Kooyk, Yvette, Storm, Gert

“…Dendritic cells (DCs) are key antigen presenting cells that have the unique ability to present antigens on MHC molecules, which can lead to either priming or…”
Get full text

A conduit system distributes chemokines and small blood-borne molecules through the splenic white pulp by Nolte, Martijn A, Beliën, Jeroen A M, Schadee-Eestermans, Inge, Jansen, Wendy, Unger, Wendy W J, van Rooijen, Nico, Kraal, Georg, Mebius, Reina E

“…Access to the splenic white pulp is restricted to lymphocytes and dendritic cells. Here we show that movement of molecules from the blood into these confined…”
Get full text

The Art and Science of Diagnosing Mycoplasma pneumoniae Infection by Meyer Sauteur, Patrick M, Unger, Wendy W J, van Rossum, Annemarie M C, Berger, Christoph

Get full text

Mycoplasma pneumoniae -Specific IFN-γ-Producing CD4 + Effector-Memory T Cells Correlate with Pulmonary Disease by Pánisová, Elena, Unger, Wendy W J, Berger, Christoph, Meyer Sauteur, Patrick M

Get full text

Infection with and Carriage of Mycoplasma pneumoniae in Children by Meyer Sauteur, Patrick M, Unger, Wendy W J, Nadal, David, Berger, Christoph, Vink, Cornelis, van Rossum, Annemarie M C

“…"Atypical" pneumonia was described as a distinct and mild form of community-acquired pneumonia (CAP) already before Mycoplasma pneumoniae had been discovered…”
Get full text

Diagnosis of Mycoplasma pneumoniae Pneumonia with Measurement of Specific Antibody-Secreting Cells by Meyer Sauteur, Patrick M, Seiler, Michelle, Trück, Johannes, Unger, Wendy W J, Paioni, Paolo, Relly, Christa, Staubli, Georg, Haas, Thorsten, Gysin, Claudine, M Bachmann, Lucas, van Rossum, Annemarie M C, Berger, Christoph

“…Mycoplasma pneumoniae (Mp) is reported to be the most common bacterial cause of community-acquired pneumonia (CAP) in hospitalized US children. However,…”
Get full text

Sialic acid-modified antigens impose tolerance via inhibition of T-cell proliferation and de novo induction of regulatory T cells by Perdicchio, Maurizio, Ilarregui, Juan M., Verstege, Marleen I., Cornelissen, Lenneke A. M., Schetters, Sjoerd T. T., Engels, Steef, Ambrosini, Martino, Kalay, Hakan, Veninga, Henrike, den Haan, Joke M. M., van Berkel, Lisette A., Samsom, Janneke N., Crocker, Paul R., Sparwasser, Tim, Berod, Luciana, Garcia-Vallejo, Juan J., van Kooyk, Yvette, Unger, Wendy W. J.

“…Sialic acids are negatively charged nine-carbon carboxylated monosaccharides that often cap glycans on glycosylated proteins and lipids. Because of their…”
Get full text

Engineering Mycoplasma pneumoniae to bypass the association with Guillain-Barré syndrome by Broto, Alicia, Piñero-Lambea, Carlos, Segura-Morales, Carolina, Tio-Gillen, Anne P., Unger, Wendy W.J., Burgos, Raul, Mazzolini, Rocco, Miravet-Verde, Samuel, Jacobs, Bart C., Casas, Josefina, Huizinga, Ruth, Lluch-Senar, Maria, Serrano, Luis

“…A non-pathogenic Mycoplasma pneumoniae-based chassis is leading the development of live biotherapeutic products (LBPs) for respiratory diseases. However,…”
Get full text

Controlled release of a model vaccine by nanoporous ceramic microneedle arrays by Boks, Martine A., Unger, Wendy W.J., Engels, Steef, Ambrosini, Martino, Kooyk, Yvette van, Luttge, Regina

“…[Display omitted] Current vaccination technology can advance from the use of novel ceramic nanoporous microneedle arrays (npMNA), where the material serves as…”
Get full text

Tumor sialylation impedes T cell mediated anti-tumor responses while promoting tumor associated-regulatory T cells by Perdicchio, Maurizio, Cornelissen, Lenneke A M, Streng-Ouwehand, Ingeborg, Engels, Steef, Verstege, Marleen I, Boon, Louis, Geerts, Dirk, van Kooyk, Yvette, Unger, Wendy W J

“…The increased presence of sialylated glycans on the tumor surface has been linked to poor prognosis, yet the effects on tumor-specific T cell immunity are…”
Get full text

Glycan-modified liposomes boost CD4+ and CD8+ T-cell responses by targeting DC-SIGN on dendritic cells by Unger, Wendy W.J., van Beelen, Astrid J., Bruijns, Sven C., Joshi, Medha, Fehres, Cynthia M., van Bloois, Louis, Verstege, Marleen I., Ambrosini, Martino, Kalay, Hakan, Nazmi, Kamran, Bolscher, Jan G., Hooijberg, Erik, de Gruijl, Tanja D., Storm, Gert, van Kooyk, Yvette

“…Cancer immunotherapy requires potent tumor-specific CD8+ and CD4+ T-cell responses, initiated by dendritic cells (DCs). Tumor antigens can be specifically…”
Get full text

Adaptable antigen matrix platforms for peptide vaccination strategies and T cell-mediated anti-tumor immunity by Schetters, Sjoerd T.T., Li, R.J. Eveline, Kruijssen, Laura J.W., Engels, Steef, Ambrosini, Martino, Garcia-Vallejo, Juan J., Kalay, Hakan, Unger, Wendy W.J., van Kooyk, Yvette

“…Injection of antigenic peptides has been widely used as a vaccine strategy to boost T cell immunity. However, the poor immunogenicity of single peptides can…”
Get full text