Search Results - "Unger, W W J"

Sialic acid-modified antigens impose tolerance via inhibition of T-cell proliferation and de novo induction of regulatory T cells by Perdicchio, Maurizio, Ilarregui, Juan M., Verstege, Marleen I., Cornelissen, Lenneke A. M., Schetters, Sjoerd T. T., Engels, Steef, Ambrosini, Martino, Kalay, Hakan, Veninga, Henrike, den Haan, Joke M. M., van Berkel, Lisette A., Samsom, Janneke N., Crocker, Paul R., Sparwasser, Tim, Berod, Luciana, Garcia-Vallejo, Juan J., van Kooyk, Yvette, Unger, Wendy W. J.

“…Sialic acids are negatively charged nine-carbon carboxylated monosaccharides that often cap glycans on glycosylated proteins and lipids. Because of their…”
Get full text

‘Dressed for success’ C-type lectin receptors for the delivery of glyco-vaccines to dendritic cells by Unger, Wendy WJ, van Kooyk, Yvette

“…Current strategies in immunotherapy for the treatment of tumors or autoimmunity focus on direct in vivo targeting of antigens to dendritic cells (DC), as these…”
Get full text

A Comprehensive Review of Recent Research into the Effects of Antimicrobial Peptides on Biofilms-January 2020 to September 2023 by Fontanot, Alessio, Ellinger, Isabella, Unger, Wendy W J, Hays, John P

“…Microbial biofilm formation creates a persistent and resistant environment in which microorganisms can survive, contributing to antibiotic resistance and…”
Get full text

Langerin-mediated internalization of a modified peptide routes antigens to early endosomes and enhances cross-presentation by human Langerhans cells by Fehres, Cynthia M, Duinkerken, Sanne, Bruijns, Sven CM, Kalay, Hakan, van Vliet, Sandra J, Ambrosini, Martino, de Gruijl, Tanja D, Unger, Wendy WJ, Garcia-Vallejo, Juan J, van Kooyk, Yvette

“…The potential of the skin immune system to generate immune responses is well established, and the skin is actively exploited as a vaccination site. Human skin…”
Get full text

Induction of Treg by monocyte-derived DC modulated by vitamin D₃ or dexamethasone: Differential role for PD-L1 by Unger, Wendy W.J, Laban, Sandra, Kleijwegt, Fleur S, van der Slik, Arno R, Roep, Bart O

“…Specific therapy with modulated DC may restore immunological tolerance, thereby obviating the need for chronic immunosuppression in transplantation or…”
Get full text

TLR Triggering on Tolerogenic Dendritic Cells Results in TLR2 Up-Regulation and a Reduced Proinflammatory Immune Program by Chamorro, Sonia, Garcia-Vallejo, Juan J, Unger, Wendy W. J, Fernandes, Rosette J, Bruijns, Sven C. M, Laban, Sandra, Roep, Bart O, t Hart, Bert A, van Kooyk, Yvette

“…Tolerogenic dendritic cells (TDC) offer a promising therapeutic potential to ameliorate autoimmune diseases. Reported to inhibit adaptive immune responses,…”
Get full text

Glycan modification of antigen alters its intracellular routing in dendritic cells, promoting priming of T cells by Streng-Ouwehand, Ingeborg, Ho, Nataschja I, Litjens, Manja, Kalay, Hakan, Boks, Martine Annemarie, Cornelissen, Lenneke A M, Kaur Singh, Satwinder, Saeland, Eirikur, Garcia-Vallejo, Juan J, Ossendorp, Ferry A, Unger, Wendy W J, van Kooyk, Yvette

“…Antigen uptake by dendritic cells and intracellular routing of antigens to specific compartments is regulated by C-type lectin receptors that recognize glycan…”
Get full text

Understanding the biology of antigen cross-presentation for the design of vaccines against cancer by Fehres, Cynthia M, Unger, Wendy W J, Garcia-Vallejo, Juan J, van Kooyk, Yvette

“…Antigen cross-presentation, the process in which exogenous antigens are presented on MHC class I molecules, is crucial for the generation of effector CD8(+) T…”
Get full text

The monocyte-derived cytokine response in whole blood from preterm newborns against sepsis-related bacteria is similar to term newborns and adults by Jans, Jop, van Dun, Sven C J, Gorissen, Renske, Pieterman, Roel F A, Voskamp, Tess S, Schoenmakers, Sam, Taal, Hendrik Robert, Unger, Wendy W J

“…Sepsis is characterized by a dysregulated innate immune response. It is a leading cause of morbidity and mortality in newborns, in particular for newborns that…”
Get full text

Identification of the immunodominant CTL epitope of EGFP in C57BL 6 mice by Han, W G H, Unger, W W J, Wauben, M H M

Get full text

Airway macrophages display decreased expression of receptors mediating and regulating scavenging in early cystic fibrosis lung disease by Slimmen, Lisa J M, Giacalone, Vincent D, Schofield, Craig, Horati, Hamed, Manaï, Badies H A N, Estevão, Silvia C, Garratt, Luke W, Peng, Limin, Tirouvanziam, Rabindra, Janssens, Hettie M, Unger, Wendy W J

“…Cystic fibrosis (CF) airway disease is characterized by chronic inflammation, featuring neutrophil influx to the lumen. Airway macrophages (AMs) can promote…”
Get full text

Outer membrane vesicles engineered to express membrane-bound antigen program dendritic cells for cross-presentation to CD8+ T cells by Schetters, Sjoerd T.T., Jong, Wouter S.P., Horrevorts, Sophie K., Kruijssen, Laura J.W., Engels, Steef, Stolk, Dorian, Daleke-Schermerhorn, Maria H., Garcia-Vallejo, Juan, Houben, Diane, Unger, Wendy W.J., den Haan, Joke M.M., Luirink, Joen, van Kooyk, Yvette

“…[Display omitted] Outer membrane vesicles (OMVs) are vesicular nano-particles produced by Gram-negative bacteria that are recently being explored as vaccine…”
Get full text

Islet-specific CTL cloned from a type 1 diabetes patient cause beta-cell destruction after engraftment into HLA-A2 transgenic NOD/scid/IL2RG null mice by Unger, Wendy W J, Pearson, Todd, Abreu, Joana R F, Laban, Sandra, van der Slik, Arno R, der Kracht, Sacha Mulder-van, Kester, Michel G D, Serreze, Dave V, Shultz, Leonard D, Griffioen, Marieke, Drijfhout, Jan Wouter, Greiner, Dale L, Roep, Bart O

“…Despite increasing evidence that autoreactive CD8 T-cells are involved in both the initiation of type 1 diabetes (T1D) and the destruction of beta-cells,…”
Get full text

Skin-resident antigen-presenting cells: instruction manual for vaccine development by Fehres, Cynthia M, Garcia-Vallejo, Juan J, Unger, Wendy W J, van Kooyk, Yvette

“…The induction of antigen-specific effector T cells is driven by proper antigen presentation and co-stimulation by dendritic cells (DCs). For this reason…”
Get full text

Glycan-modified liposomes boost CD4+ and CD8+ T-cell responses by targeting DC-SIGN on dendritic cells by Unger, Wendy W.J., van Beelen, Astrid J., Bruijns, Sven C., Joshi, Medha, Fehres, Cynthia M., van Bloois, Louis, Verstege, Marleen I., Ambrosini, Martino, Kalay, Hakan, Nazmi, Kamran, Bolscher, Jan G., Hooijberg, Erik, de Gruijl, Tanja D., Storm, Gert, van Kooyk, Yvette

“…Cancer immunotherapy requires potent tumor-specific CD8+ and CD4+ T-cell responses, initiated by dendritic cells (DCs). Tumor antigens can be specifically…”
Get full text

Glycan-based DC-SIGN targeting vaccines to enhance antigen cross-presentation by van Kooyk, Yvette, Unger, Wendy W.J., Fehres, Cynthia M., Kalay, Hakan, García-Vallejo, Juan J.

“…► Leb and LeX glycans achieve an efficient antigen-targeting to DCs through DC-SIGN. ► Glycan multivalency is a necessary condition for efficient targeting. ►…”
Get full text

Antigen-Presenting Cells in the Airways: Moderating Asymptomatic Bacterial Carriage by Slimmen, Lisa J. M., Janssens, Hettie M., van Rossum, Annemarie M. C., Unger, Wendy W. J.

“…Bacterial respiratory tract infections (RTIs) are a major global health burden, and the role of antigen-presenting cells (APCs) in mounting an immune response…”
Get full text

Galacto-Oligosaccharides as an Anti-Infective and Anti-Microbial Agent for Macrolide-Resistant and -Sensitive Mycoplasma pneumoniae by Zhu, Hongzhen, Cai, Yang, Slimmen, Lisa J M, de Bruijn, Adrianus C J M, van Rossum, Annemarie M C, Folkerts, Gert, Braber, Saskia, Unger, Wendy W J

“…The worldwide increase in the incidence of antibiotic resistance of the atypical bacterium (MP) challenges the treatment of MP infections, especially in…”
Get full text

The Omega‐6 Lipid pathway shift is associated with neutrophil influx and structural lung damage in early cystic fibrosis lung disease by Slimmen, Lisa JM, Broos, Jelle Y, Manaï, Badies HAN, Estevão, Silvia C, Giera, Martin, Kooij, Gijs, Unger, Wendy WJ, Janssens, Hettie M

“…Objectives In cystic fibrosis (CF), an imbalanced lipid metabolism is associated with lung inflammation. Little is known about the role that specific lipid…”
Get full text

Glycan-based DC-SIGN targeting to enhance antigen cross-presentation in anticancer vaccines by García-Vallejo, Juan J., Unger, Wendy W. J., Kalay, Hakan, van Kooyk, Yvette

“…In vivo dendritic-cell targeting constitutes a promising strategy for anticancer vaccination. Here, we discuss the usage of multivalent DC-SIGN-targeting…”
Get full text