Search Results - "Unger, Vinzenz M."

The BAR Domain Superfamily: Membrane-Molding Macromolecules by Frost, Adam, Unger, Vinzenz M., De Camilli, Pietro

“…Membrane-shaping proteins of the BAR domain superfamily are determinants of organelle biogenesis, membrane trafficking, cell division, and cell migration. An…”
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Structural Basis of Membrane Bending by the N-BAR Protein Endophilin by Mim, Carsten, Cui, Haosheng, Gawronski-Salerno, Joseph A., Frost, Adam, Lyman, Edward, Voth, Gregory A., Unger, Vinzenz M.

“…Functioning as key players in cellular regulation of membrane curvature, BAR domain proteins bend bilayers and recruit interaction partners through poorly…”
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Understanding the Role of Amphipathic Helices in N-BAR Domain Driven Membrane Remodeling by Cui, Haosheng, Mim, Carsten, Vázquez, Francisco X., Lyman, Edward, Unger, Vinzenz M., Voth, Gregory A.

“…Endophilin N-BAR (N-terminal helix and Bin/amphiphysin/Rvs) domain tubulates and vesiculates lipid membranes in vitro via its crescent-shaped dimer and four…”
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Structural Basis of Membrane Invagination by F-BAR Domains by Frost, Adam, Perera, Rushika, Roux, Aurélien, Spasov, Krasimir, Destaing, Olivier, Egelman, Edward H., De Camilli, Pietro, Unger, Vinzenz M.

“…BAR superfamily domains shape membranes through poorly understood mechanisms. We solved structures of F-BAR modules bound to flat and curved bilayers using…”
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Protein-Mediated Transformation of Lipid Vesicles into Tubular Networks by Simunovic, Mijo, Mim, Carsten, Marlovits, Thomas C., Resch, Guenter, Unger, Vinzenz M., Voth, Gregory A.

“…Key cellular processes are frequently accompanied by protein-facilitated shape changes in the plasma membrane. N-BAR-domain protein modules generate curvature…”
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Three-dimensional structure of the human copper transporter hCTR1 by De Feo, Christopher J, Aller, Stephen G, Siluvai, Gnana S, Blackburn, Ninian J, Unger, Vinzenz M

“…Copper uptake proteins (CTRs), mediate cellular acquisition of the essential metal copper in all eukaryotes. Here, we report the structure of the human CTR1…”
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Cellular distribution of copper to superoxide dismutase involves scaffolding by membranes by Pope, Christopher R., De Feo, Christopher J., Unger, Vinzenz M.

“…Efficient delivery of copper ions to specific intracellular targets requires copper chaperones that acquire metal cargo through unknown mechanisms. Here we…”
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Projection Structure of the Human Copper Transporter CTR1 at 6-Å Resolution Reveals a Compact Trimer with a Novel Channel-Like Architecture by Aller, Stephen G., Unger, Vinzenz M.

“…Human CTR1 is a high-affinity copper transporter that also mediates the uptake of the anticancer drug cisplatin by largely unknown transport mechanisms. Here…”
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Autoinhibition of Endophilin in Solution via Interdomain Interactions by Vázquez, Francisco X., Unger, Vinzenz M., Voth, Gregory A.

“…Endophilin is a key protein involved in clathrin-mediated endocytosis. Previous computational and experimental work suggested that the N-terminal helix is…”
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Structure, domain organization, and different conformational states of stem cell factor-induced intact KIT dimers by Opatowsky, Yarden, Lax, Irit, Tomé, Francisco, Bleichert, Franziska, Unger, Vinzenz M., Schlessinger, Joseph

“…Using electron microscopy and fitting of crystal structures, we present the 3D reconstruction of ligand-induced dimers of intact receptor tyrosine kinase, KIT…”
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Structure of the transmembrane regions of a bacterial cyclic nucleotide-regulated channel by Clayton, Gina M, Altieri, Steve, Heginbotham, Lise, Unger, Vinzenz M, Morais-Cabral, João H

“…The six-transmembrane helix (6 TM) tetrameric cation channels form the largest ion channel family, some members of which are voltage-gated and others are not…”
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Assembly of the inner rod determines needle length in the type III secretion injectisome by Galán, Jorge E, Marlovits, Thomas C, Kubori, Tomoko, Lara-Tejero, María, Thomas, Dennis, Unger, Vinzenz M

“…Assembly of multi-component supramolecular machines is fundamental to biology, yet in most cases, assembly pathways and their control are poorly understood. An…”
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Membrane curvature and its generation by BAR proteins by Mim, Carsten, Unger, Vinzenz M.

“…Membranes are flexible barriers that surround the cell and its compartments. To execute vital functions such as locomotion or receptor turnover, cells need to…”
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Three-Dimensional Structure of a Recombinant Gap Junction Membrane Channel by Unger, Vinzenz M., Kumar, Nalin M., Gilula, Norton B., Yeager, Mark

“…Gap junction membrane channels mediate electrical and metabolic coupling between adjacent cells. The structure of a recombinant cardiac gap junction channel…”
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Tryptophan Scanning Analysis of the Membrane Domain of CTR-Copper Transporters by De Feo, Christopher J, Mootien, Sara, Unger, Vinzenz M

“…Membrane proteins of the CTR family mediate cellular copper uptake in all eukaryotic cells and have been shown to participate in uptake of platinum-based…”
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Dimeric Structure for Archaeal Box C/D Small Ribonucleoproteins by Bleichert, Franziska, Gagnon, Keith T, Brown, Bernard A. II, Maxwell, E. Stuart, Leschziner, Andres E, Unger, Vinzenz M, Baserga, Susan J

“…Methylation of ribosomal RNA (rRNA) is required for optimal protein synthesis. Multiple 2'-O-ribose methylations are carried out by box C/D guide…”
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The Membrane Protein FeoB Contains an Intramolecular G Protein Essential for Fe(II) Uptake in Bacteria by Marlovits, Thomas C., Haase, Winfried, Herrmann, Christian, Aller, Stephen G., Unger, Vinzenz M.

“…G proteins are critical for the regulation of membrane protein function and signal transduction. Nevertheless, coupling between G proteins and membrane…”
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Eukaryotic CTR Copper Uptake Transporters Require Two Faces of the Third Transmembrane Domain for Helix Packing, Oligomerization, and Function by Aller, Stephen G., Eng, Edward T., De Feo, Christopher J., Unger, Vinzenz M.

“…Members of the copper uptake transporter (CTR) family from yeast, plants, and mammals including human are required for cellular uptake of the essential metal…”
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Expression, solubilization, and biochemical characterization of the tight junction transmembrane protein claudin‐4 by Mitic, Laura L., Unger, Vinzenz M., Anderson, James Melvin

“…The tight junction tetraspan protein claudin‐4 creates a charge‐selective pore in the paracellular pathway across epithelia. The structure of the pore is…”
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Human copper transporter ATP7B (Wilson disease protein) forms stable dimers in vitro and in cells by Jayakanthan, Samuel, Braiterman, Lelita T., Hasan, Nesrin M., Unger, Vinzenz M., Lutsenko, Svetlana

“…ATP7B is a copper-transporting P1B-type ATPase (Cu-ATPase) with an essential role in human physiology. Mutations in ATP7B cause the potentially fatal Wilson…”
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