Search Results - "Unger, Steve E."

Direct Plasma Sample Injection in Multiple-Component LC−MS−MS Assays for High-Throughput Pharmacokinetic Screening by Wu, Jing-Tao, Zeng, Hang, Qian, Mingxin, Brogdon, Bernice L, Unger, Steve E

“…The simultaneous dosing of numerous compounds followed by multiple-component analysis using LC−MS−MS (the N-in-1 approach) has significantly improved the…”
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N-in-1 dosing pharmacokinetics in drug discovery: experience, theoretical and practical considerations by He, Kan, Qian, Mingxin, Wong, Harvey, Bai, Stephen A, He, Bing, Brogdon, Bernice, Grace, James E, Xin, Baomin, Wu, Jingtao, Ren, Shelly X, Zeng, Hang, Deng, Yuzhong, Graden, Danielle M, Olah, Timothy V, Unger, Steve E, Luettgen, Joseph M, Knabb, Robert M, Pinto, Donald J, Lam, Patrick Y S, Duan, James, Wexler, Ruth R, Decicco, Carl P, Christ, David D, Grossman, Scott J

“…N-in-1 (or cassette) dosing pharmacokinetics (PK) has been used in drug discovery for rapid assessment of PK properties of new chemical entities. However,…”
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A simplified protein precipitation/mixed-mode cation-exchange solid-phase extraction, followed by high-speed liquid chromatography/mass spectrometry, for the determination of a basic drug in human plasma by Xue, Y.-J., Akinsanya, J. Billy, Liu, Jane, Unger, Steve E.

“…A simplified protein precipitation/mixed‐mode cation‐exchange solid‐phase extraction (PPT/SPE) procedure has been investigated. A mixture of acetonitrile and…”
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Comparison of SPE and fast LC to eliminate mass spectrometric matrix effects from microsomal incubation products by Zheng, Joanna J., Lynch, Eric D., Unger, Steve E.

“…Twenty-seven highly diversified pharmaceutical compounds were used as a test set to evaluate matrix effects from microsomal media on LC/MS analyses. The…”
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Safety Assessment of Drug Metabolites:  Characterization of Chemically Stable Metabolites by Humphreys, W. Griffith, Unger, Steve E.

“…Drug molecules are typically subjected to a variety of biotransformation reactions, and the metabolites formed through these reactions must be considered when…”
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Pharmacokinetic Interaction Between Efavirenz and Carbamazepine After Multiple-Dose Administration in Healthy Subjects by Ji, Ping, Damle, Bharat, Xie, Jingdong, Unger, Steve E., Grasela, Dennis M., Kaul, Sanjeev

“…The effect of efavirenz on the pharmacokinetics of carbamazepine and vice versa was investigated in adult healthy subjects in a randomized, open‐label,…”
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High-speed gradient parallel liquid chromatography/tandem mass spectrometry with fully automated sample preparation for bioanalysis: 30 seconds per sample from plasma by Deng, Yuzhong, Wu, Jing-Tao, Lloyd, Thomas L., Chi, Cecilia L., Olah, Timothy V., Unger, Steve E.

“…In this work, a high‐throughput and high‐performance bioanalytical system is described that is capable of extracting and analyzing 1152 plasma samples within…”
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Analysis and validation of the phosphorylated metabolites of two anti-human immunodeficiency virus nucleotides (stavudine and didanosine) by pressure-assisted CE-ESI-MS/MS in cell extracts: Sensitivity enhancement by the use of perfluorinated acids and alcohols as coaxial sheath-liquid make-up constituents by Bezy, Vincent, Chaimbault, Patrick, Morin, Philippe, Unger, Steve E., Bernard, Marie-Charlotte, Agrofoglio, Luigi A.

“…A CE method utilizing triple quadrupole electrospray (ES) MS (MS/MS) detection was developed and validated for the simultaneous measurement of nucleoside…”
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Structure determination of lysobactin, a macrocyclic peptide lactone antibiotic by Tymiak, Adrienne A, McCormick, Terrence J, Unger, Steve E

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The investigation and the use of high flow column-switching LC/MS/MS as a high-throughput approach for direct plasma sample analysis of single and multiple components in pharmacokinetic studies by Zeng, Hang, Wu, Jing-Tao, Unger, Steve E

“…Recently direct plasma injection LC/MS/MS technique has been increasingly used in pharmaceutical research and development due to the demand for higher…”
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NMR and HPLC-NMR spectroscopic studies of futile deacetylation in paracetamol metabolites in rat and man by Nicholls, Andrew W, Duncan Farrant, R, Shockcor, John P, Unger, Steve E, Wilson, Ian D, Lindon, John C, Nicholson, Jeremy K

“…HPLC-NMR spectroscopy has been used to investigate the level of deacetylation followed by reacetylation (futile deacetylation) of metabolites of paracetamol…”
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Combined HPLC, NMR Spectroscopy, and Ion-Trap Mass Spectrometry with Application to the Detection and Characterization of Xenobiotic and Endogenous Metabolites in Human Urine by Shockcor, John P, Unger, Steve E, Wilson, Ian D, Foxall, Peta J. D, Nicholson, Jeremy K, Lindon, John C

“…The direct coupling of HPLC with NMR spectroscopy has been extended by splitting the HPLC eluent after conventional UV detection and sending part to a NMR…”
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Neutral, seven-coordinate dioxime complexes of technetium(III): synthesis and characterization by Linder, Karen E, Malley, Mary F, Gougoutas, Jack Z, Unger, Steve E, Nunn, Adrian D

“…The tin-capped complexes {sup 99}Tc(oxime){sub 3}({mu}-OH)SnCl{sub 3} (oxime = dimethylglyoxime (DMG) or cyclohexanedione dioxime (CDO)) can be prepared by the…”
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Separation of a BMS drug candidate and acyl glucuronide from seven glucuronide positional isomers in rat plasma via high-performance liquid chromatography with tandem mass spectrometric detection by Xue, Y.-J., Simmons, Neal J., Liu, Jane, Unger, Steve E., Anderson, Danielle F., Jenkins, Rand G.

“…A high‐performance liquid chromatography/tandem mass spectrometry (LC/MS/MS) method has been developed and validated for the determination of a BMS drug…”
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Application of directly coupled LC–NMR–MS to the structural elucidation of metabolites of the HIV-1 reverse-transcriptase inhibitor BW935U83 by Shockcor, John P, Unger, Steve E, Savina, Paul, Nicholson, Jeremy K, Lindon, John C

“…The human in vivo metabolism of the HIV-1 reverse transcriptase inhibitor 5-chloro-1-(2′,3′-dideoxy-3′-fluoro- erythro-pentofuranosyl)uracil (BW935U83) was…”
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Fast atom bombardment mass spectrometry/mass spectrometry of cationic technetium and iron complexes by Unger, Steve E

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High-speed liquid chromatography/tandem mass spectrometry using a monolithic column for high-throughput bioanalysis by Wu, Jing-Tao, Zeng, Hang, Deng, Yuzhong, Unger, Steve E.

“…With the ever‐increasing workload from a variety of in vitro and in vivo screening procedures, new analytical methodologies to perform bioanalysis in an…”
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Differentiation of cationic from neutral transition metal complexes using wires as field desorption emitters by Unger, Steve E

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A novel reaction between acetone and the benzo[c]phenanthrene K-region o-quinone containing a peri-fluoro substituent by Patrick, Mark A, Sethi, Satinder K, Unger, Steve E, Mirsadeghi, Seid, Ribeiro, Anthony A, Thakker, Dhiren R

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Comparison of desorption ionization methods for the analysis of neutral seven-coordinate technetium radiopharmaceuticals by Unger, Steve E, McCormick, Terry J, Treher, Elizabeth N, Nunn, Adrian D

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