Search Results - "Unger, Roger"

Glucagonocentric restructuring of diabetes: a pathophysiologic and therapeutic makeover by Unger, Roger H, Cherrington, Alan D

“…The hormone glucagon has long been dismissed as a minor contributor to metabolic disease. Here we propose that glucagon excess, rather than insulin deficiency,…”
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Paracrinology of islets and the paracrinopathy of diabetes by Unger, Roger H., Orci, Lelio

“…New results have brought to light the importance of the regulation of glucagon by β-cells in the development of diabetes. In this perspective, we examine the…”
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Gluttony, sloth and the metabolic syndrome: a roadmap to lipotoxicity by Unger, Roger H, Scherer, Philipp E

“…Once considered divine retribution for sins, comorbidities of obesity (metabolic syndrome) are today attributed to obesity-induced metabolic defects. Here, we…”
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Glucagon is the key factor in the development of diabetes by Lee, Young H., Wang, May-Yun, Yu, Xin-Xin, Unger, Roger H.

“…Glucagon plays important roles in normal glucose homeostasis and in metabolic abnormalities, particularly diabetes. Glucagon excess, rather than insulin…”
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Glucagon Receptor Knockout Prevents Insulin-Deficient Type 1 Diabetes in Mice by LEE, Young, WANG, May-Yun, XIU QUAN DU, CHARRON, Maureen J, UNGER, Roger H

“…To determine the role of glucagon action in the metabolic phenotype of untreated insulin deficiency. We compared pertinent clinical and metabolic parameters in…”
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Minireview: Weapons of Lean Body Mass Destruction: The Role of Ectopic Lipids in the Metabolic Syndrome by Unger, Roger H

“…The obesity crisis in the United States has been associated with an alarming increase in the prevalence of the metabolic syndrome (MSX) disease cluster. Here…”
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Clinical Trials, Triumphs, and Tribulations of Glucagon Receptor Antagonists by Pearson, Mackenzie J, Unger, Roger H, Holland, William L

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Obesity dysregulates fasting-induced changes in glucagon secretion by Stern, Jennifer H, Smith, Gordon I, Chen, Shiuwei, Unger, Roger H, Klein, Samuel, Scherer, Philipp E

“…Hyperglucagonemia, a hallmark in obesity and insulin resistance promotes hepatic glucose output, exacerbating hyperglycemia and thus predisposing to the…”
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Reinventing Type 2 Diabetes: Pathogenesis, Treatment, and Prevention by Unger, Roger H

“…The novel lipocentric view depicts the hyperglycemia of type two diabetes, and the underlying insulin resistance and beta cell loss, as being secondary to the…”
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LIPOTOXIC DISEASES by Unger, Roger H

“…I review evidence that leptin is a liporegulatory hormone that controls lipid homeostasis in nonadipose tissues during periods of overnutrition. When…”
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A New Biology of Diabetes Revealed by Leptin by Unger, Roger H., Roth, Michael G.

“…A variety of leptin actions require a re-examination of classic concepts of metabolic diseases. Here we present evidence for two physiologic pathways: a…”
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Glucagon receptor antibody completely suppresses type 1 diabetes phenotype without insulin by disrupting a novel diabetogenic pathway by Wang, May-Yun, Yan, Hai, Shi, Zhiqing, Evans, Matthew R., Yu, Xinxin, Lee, Young, Chen, Shiuhwei, Williams, Annie, Philippe, Jacques, Roth, Michael G., Unger, Roger H.

“…Insulin monotherapy can neither maintain normoglycemia in type 1 diabetes (T1D) nor prevent the long-term damage indicated by elevated glycation products in…”
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Metabolic manifestations of insulin deficiency do not occur without glucagon action by Lee, Young, Berglund, Eric D., Wang, May-yun, Fu, Xiaorong, Yu, Xinxin, Charron, Maureen J., Burgess, Shawn C., Unger, Roger H.

“…To determine unambiguously if suppression of glucagon action will eliminate manifestations of diabetes, we expressed glucagon receptors in livers of glucagon…”
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Making insulin-deficient type 1 diabetic rodents thrive without insulin by Yu, Xinxin, Park, Byung-Hyun, Wang, May-Yun, Wang, Zhao V, Unger, Roger H

“…Terminally ill insulin-deficient rodents with uncontrolled diabetes due to autoimmune or chemical destruction of β-cells were made hyperleptinemic by…”
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Diabetes and apoptosis: lipotoxicity by Kusminski, Christine M, Shetty, Shoba, Orci, Lelio, Unger, Roger H, Scherer, Philipp E

“…Obesity is an established risk factor in the pathogenesis of insulin resistance, type 2 diabetes mellitus and cardiovascular disease; all components that are…”
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Insulin and Glucagon: Partners for Life by Holst, Jens Juul, Holland, William, Gromada, Jesper, Lee, Young, Unger, Roger H., Yan, Hai, Sloop, Kyle W., Kieffer, Timothy J., Damond, Nicolas, Herrera, Pedro L.

“…Is glucagon essential for the hyperglycemia in insulin deficiency, as suggested by experimental glucagon antagonism? No, sufficient levels of basal insulin…”
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Leptin therapy in insulin-deficient type I diabetes by Wang, May-yun, Chen, Lijun, Clark, Gregory O, Lee, Young, Stevens, Robert D, Ilkayeva, Olga R, Wenner, Brett R, Bain, James R, Charron, Maureen J, Newgard, Christopher B, Unger, Roger H

“…In nonobese diabetic mice with uncontrolled type 1 diabetes, leptin therapy alone or combined with low-dose insulin reverses the catabolic state through…”
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Forgotten but Not Gone: The Rediscovery of Fatty Heart, the Most Common Unrecognized Disease in America by Szczepaniak, Lidia S, Victor, Ronald G, Orci, Lelio, Unger, Roger H

“…Until 60 years ago, fatty heart was an accepted clinical entity. Since then, its very existence has been questioned, despite the fact that 2 of 3 Americans are…”
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Hyperglycemia in rodent models of type 2 diabetes requires insulin-resistant alpha cells by Lee, Young, Berglund, Eric D., Yu, Xinxin, Wang, May-Yun, Evans, Matthew R., Scherer, Philipp E., Holland, William L., Charron, Maureen J., Roth, Michael G., Unger, Roger H.

“…Significance Diet-induced type 2 diabetes (T2D) is becoming a worldwide epidemic. Patients with T2D fail to respond to insulin normally and have elevated blood…”
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Glucagon blockade restores functional β-cell mass in type 1 diabetic mice and enhances function of human islets by Wang, May-Yun, Dean, E. Danielle, Quittner-Strom, Ezekiel, Zhu, Yi, Chowdhury, Kamrul H., Zhang, Zhuzhen, Zhao, Shangang, Li, Na, Ye, Reshing, Lee, Young, Zhang, Yiyi, Chen, Shiuhwei, Yu, Xinxin, Leonard, Derek C., Poffenberger, Greg, Von Deylen, Alison, McCorkle, S. Kay, Schlegel, Amnon, Sloop, Kyle W., Efanov, Alexander M., Gimeno, Ruth E., Scherer, Philipp E., Powers, Alvin C., Unger, Roger H., Holland, William L.

“…We evaluated the potential for a monoclonal antibody antagonist of the glucagon receptor (Ab-4) to maintain glucose homeostasis in type 1 diabetic rodents. We…”
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