Search Results - "Unger, Gretchen M."

Preclinical evaluation of cyclin dependent kinase 11 and casein kinase 2 survival kinases as RNA interference targets for triple negative breast cancer therapy by Kren, Betsy T, Unger, Gretchen M, Abedin, Md J, Vogel, Rachel I, Henzler, Christine M, Ahmed, Khalil, Trembley, Janeen H

“…Targeted therapies for aggressive breast cancers like triple negative breast cancer (TNBC) are needed. The use of small interfering RNAs (siRNAs) to disable…”
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Tenfibgen ligand nanoencapsulation delivers bi-functional anti-CK2 RNAi oligomer to key sites for prostate cancer targeting using human xenograft tumors in mice by Trembley, Janeen H, Unger, Gretchen M, Korman, Vicci L, Abedin, Md Joynal, Nacusi, Lucas P, Vogel, Rachel I, Slaton, Joel W, Kren, Betsy T, Ahmed, Khalil

“…Protected and specific delivery of nucleic acids to malignant cells remains a highly desirable approach for cancer therapy. Here we present data on the…”
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Mechanism and efficacy of sub-50-nm tenfibgen nanocapsules for cancer cell-directed delivery of anti-CK2 RNAi to primary and metastatic squamous cell carcinoma by Unger, Gretchen M, Kren, Betsy T, Korman, Vicci L, Kimbrough, Tyler G, Vogel, Rachel I, Ondrey, Frank G, Trembley, Janeen H, Ahmed, Khalil

“…Improved survival for patients with head and neck cancers (HNC) with recurrent and metastatic disease warrants that cancer therapy is specific, with protected…”
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CK2 Molecular Targeting-Tumor Cell-Specific Delivery of RNAi in Various Models of Cancer by Trembley, Janeen H, Kren, Betsy T, Abedin, Md Joynal, Vogel, Rachel I, Cannon, Claire M, Unger, Gretchen M, Ahmed, Khalil

“…Protein kinase CK2 demonstrates increased protein expression relative to non-transformed cells in the majority of cancers that have been examined. The elevated…”
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Induction of apoptosis by antisense CK2 in human prostate cancer xenograft model by Slaton, Joel W, Unger, Gretchen M, Sloper, Daniel T, Davis, Alan T, Ahmed, Khalil

“…Protein serine/threonine kinase CK2 (formerly casein kinase 2) is a ubiquitous protein kinase that plays key roles in cell growth, proliferation, and survival…”
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Nanocapsule-delivered Sleeping Beauty mediates therapeutic Factor VIII expression in liver sinusoidal endothelial cells of hemophilia A mice by Kren, Betsy T, Unger, Gretchen M, Sjeklocha, Lucas, Trossen, Alycia A, Korman, Vicci, Diethelm-Okita, Brenda M, Reding, Mark T, Steer, Clifford J

“…Liver sinusoidal endothelial cells are a major endogenous source of Factor VIII (FVIII), lack of which causes the human congenital bleeding disorder hemophilia…”
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Nanoencapsulated anti-CK2 small molecule drug or siRNA specifically targets malignant cancer but not benign cells by Trembley, Janeen H, Unger, Gretchen M, Korman, Vicci L, Tobolt, Diane K, Kazimierczuk, Zygmunt, Pinna, Lorenzo A, Kren, Betsy T, Ahmed, Khalil

“…Abstract CK2, a pleiotropic Ser/Thr kinase, is an important target for cancer therapy. We tested our novel tenfibgen-based nanocapsule for delivery of the…”
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Abstract 3746: A high dose priming strategy with the novel RNAi therapeutic GS-10 elevates RISC Ago2, Ago4 and GW182 protein levels to enhance RNAi efficacy in a metastatic solid tumor model by Nacusi, Lucas P., Korman, Vicci L., Pretti, Alex J., Tobolt, Diane K., Mendoza, Alvaro, Unger, Gretchen M.

“…Abstract A high initial priming dose of the novel RNAi therapeutic GS-10 was investigated as a strategy to elevate important RISC complex proteins that have…”
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Evaluation of protein kinase CK2 as a therapeutic target for squamous cell carcinoma of cats by Cannon, Claire M, Trembley, Janeen H, Kren, Betsy T, Unger, Gretchen M, O'Sullivan, M Gerard, Cornax, Ingrid, Modiano, Jaime F, Ahmed, Khalil

“…OBJECTIVE To investigate protein kinase CK2 (CK2) expression in squamous cell carcinoma (SCC) of cats and to examine effects of CK2 downregulation on in vitro…”
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CK2 targeted RNAi therapeutic delivered via malignant cell-directed tenfibgen nanocapsule: dose and molecular mechanisms of response in xenograft prostate tumors by Ahmed, Khalil, Kren, Betsy T, Abedin, Md Joynal, Vogel, Rachel I, Shaughnessy, Daniel P, Nacusi, Lucas, Korman, Vicci L, Li, Yingming, Dehm, Scott M, Zimmerman, Cheryl L, Niehans, Gloria A, Unger, Gretchen M, Trembley, Janeen H

“…CK2, a protein serine/threonine kinase, promotes cell proliferation and suppresses cell death. This essential-for-survival signal demonstrates elevated…”
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Systemic administration of antisense oligonucleotides simultaneously targeting CK2α and α′ subunits reduces orthotopic xenograft prostate tumors in mice by Trembley, Janeen H., Unger, Gretchen M., Tobolt, Diane K., Korman, Vicci L., Wang, Guixia, Ahmad, Kashif A., Slaton, Joel W., Kren, Betsy T., Ahmed, Khalil

“…CK2 is a highly conserved, ubiquitous, signal responsive protein serine/threonine kinase. CK2 promotes cell proliferation and suppresses apoptosis, and…”
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Therapeutic Targeting of Protein Kinase CK2 Gene Expression in Feline Oral Squamous Cell Carcinoma: A Naturally Occurring Large-Animal Model of Head and Neck Cancer by Cannon, Claire M, Trembley, Janeen H, Kren, Betsy T, Unger, Gretchen M, O'Sullivan, M Gerard, Cornax, Ingrid, Modiano, Jaime F, Ahmed, Khalil

“…Protein kinase CK2 (CK2) is a highly promising target for cancer therapy, and anti-CK2 gene expression therapy has shown effectiveness in rodent models of…”
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Improving Surgical Wound Healing with Basic Fibroblast Growth Factor after Radiation by Hom, David B., Unger, Gretchen M., Pernell, Kerri J., Manivel, J Carlos

“…Objectives/Hypothesis: Delayed wound healing in surgical patients who have received previous irradiation continues to be a significant problem. We investigated…”
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Tenfibgen-DMAT Nanocapsule Delivers CK2 Inhibitor DMAT to Prostate Cancer Xenograft Tumors Causing Inhibition of Cell Proliferation by Trembley, Janeen H, Unger, Gretchen M, Gomez, Omar Cespedes, Abedin, J, Korman, Vicci L, Vogel, Rachel I, Niehans, Gloria, Kren, Betsy T, Ahmed, Khalil

“…CK2 is a master regulator protein kinase which demonstrates heightened expression in diverse cancer types and is considered a promising target for therapy…”
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1081. Targeted Nanocapsules for Liver Cell-Type Delivery of Plasmids In Vivo by Kren, Betsy T., Unger, Gretchen M., Reding, Mark T., Steer, Clifford J.

“…In contrast to the efficient delivery afforded by viral vectors, the use of nonviral vectors for gene therapy has been hindered by the lack of adequate in vivo…”
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Abstract 23: Precision medicine approaches to Fanconi anemia oral cancer personalized prevention and treatment by Swenson, Daniel K., Wuertz, Beverly R., Ali, Mustafa M., Unger, Gretchen M., Ondrey, Frank G.

“…Abstract There is an increased risk of oral cavity and other head and neck cancers as Fanconi patients live longer post transplantation. DNA repair defects in…”
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Abstract 2590: Genomic analysis points to fibrosis and changes in fat metabolism in oral cancer progression by Unger, Gretchen M., Wuertz, Beverly R., Pruett, Charles L., Watkins, Matthew, Gaffney, Patrick M., Ondrey, Frank G.

“…Abstract Head and neck cancer long term survival has only experienced marginal gains over the past 3 decades. Further, there is inadequate understanding of the…”
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Abstract P199: Tenfibgen nanoencapsulated RNAi feCK2 inhibits protein kinase CK2 and induces apoptosis in feline oral squamous cell carcinomas in vivo by Ondrey, Frank G., Unger, Gretchen M., Cannon, Claire M., Trembley, Janeen H., Kren, BT, Modiano, Jaime F., Ahmed, Khalil

“…Abstract In an initial safety evaluation in domestic cats suffering from oral squamous cell carcinomas (FOSCC), nine cat subjects were treated IV with 5-6…”
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Abstract 5272: 3D cell-culture strategy for screening novel agents in Fanconi anemia chemoprevention by Unger, Gretchen M., Wuertz, Beverly R., Brown, Mary E., Arji, Sanjana, Trembley, Janeen H., Ondrey, Frank G.

“…Abstract Fanconi anemia (FA) patients have DNA repair mutations predisposing them to oral cancers so treatment with non-DNA damaging agents is highly desired…”
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A Wound-Induced [Ca2+]iIncrease and Its Transcriptional Activation of Immediate Early Genes Is Important in the Regulation of Motility by Tran, Phuong Oanh T., Hinman, Lee E., Unger, Gretchen M., Sammak, Paul J.

“…Upon mechanical wounding of a confluent quiescent monolayer, cells move into the denuded zone. However, it is not well known what signaling cascade connects…”
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