Search Results - "Unger, E F"

Angiogenic-induced enhancement of collateral blood flow to ischemic myocardium by vascular endothelial growth factor in dogs by BANAI, S, JAKLITSCH, M. T, SHOU, M, LAZAROUS, D. F, SCHEINOWITZ, M, BIRO, S, EPSTEIN, S. E, UNGER, E. F

“…Vascular endothelial growth factor (VEGF) is an endothelial cell-specific mitogen that is angiogenic in vitro and in vivo. It has been hypothesized that VEGF…”
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Basic fibroblast growth factor enhances myocardial collateral flow in a canine model by Unger, E F, Banai, S, Shou, M, Lazarous, D F, Jaklitsch, M T, Scheinowitz, M, Correa, R, Klingbeil, C, Epstein, S E

“…Basic fibroblast growth factor (FGF) is a multifunctional peptide that may play an integral role in angiogenesis associated with coronary collateral formation…”
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Effects of a single intracoronary injection of basic fibroblast growth factor in stable angina pectoris by Unger, Ellis F, Goncalves, Lino, Epstein, Stephen E, Chew, Emily Y, Trapnell, Carol Braun, Cannon, Richard O, Quyyumi, Arshed A, Loscalzo, Francis, Stiber, Jonathan A

“…We sought to evaluate safety, tolerability, pharmacokinetics, and pharmacodynamics of basic fibroblast growth factor (bFGF), administered as a single…”
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Pharmacodynamics of basic fibroblast growth factor: route of administration determines myocardial and systemic distribution by LAZAROUS, D. F, SHOU, M, STIBER, J. A, DADHANIA, D. M, THIRUMURTI, V, HODGE, E, UNGER, E. F

“…We have shown that basic fibroblast growth factor (bFGF/FGF-2) enhances myocardial collateral development in a canine model of progressive coronary occlusion…”
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Intracoronary basic fibroblast growth factor enhances myocardial collateral perfusion in dogs by Rajanayagam, M.A.Sharmini, Shou, Matie, Thirumurti, Venugopal, Lazarous, Daisy F, Quyyumi, Arshed A, Goncalves, Lino, Stiber, Jonathan, Epstein, Stephen E, Unger, Ellis F

“…OBJECTIVES In preparation for clinical trials of basic fibroblast growth factor (bFGF) to treat ischemic heart disease, we sought to identify a clinically…”
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Investigation of the Mechanism of Chest Pain in Patients With Angiographically Normal Coronary Arteries Using Transesophageal Dobutamine Stress Echocardiography by Panza, Julio A, Laurienzo, Joy M, Curiel, Rodolfo V, Unger, Ellis F, Quyyumi, Arshed A, Dilsizian, Vasken, Cannon, Richard O

“…Objectives. The present study sought to determine whether myocardial contractile abnormalities accompany the development of chest pain in patients with normal…”
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Cytomegalovirus infection of rats increases the neointimal response to vascular injury without consistent evidence of direct infection of the vascular wall by YI FU ZHOU, SHOU, M, GUETTA, E, GUZMAN, R, UNGER, E. F, ZU XI YU, JUN ZHANG, FINKEL, T, EPSTEIN, S. E

“…Previous studies suggest that infection may play a role in restenosis and atherogenesis; cytomegalovirus (CMV) is one of the implicated pathogens. To determine…”
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Effects of Acidic Fibroblast Growth Factor on Normal and Ischemic Myocardium by Banai, Shmuel, Jaklitsch, Michael T, Casscells, Ward, Shou, Matie, Shrivastav, Shashi, Correa, Rosaly, Epstein, Stephen E, Unger, Ellis F

“…We sought to determine the effects of acidic fibroblast growth factor (FGF) on ischemic and normal myocardium and to determine whether direct application of…”
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Heparin promotes the formation of extracardiac to coronary anastomoses in a canine model by Unger, E F, Sheffield, C D, Epstein, S E

“…We developed a canine model for the in vivo utilization of angiogenesis factors to promote revascularization of a collateral-dependent area of the heart and…”
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Chronic non-vascular cytomegalovirus infection : effects on the neointimal response to experimental vascular injury by YI FU ZHOU, SHOU, M, HARRELL, R. F, ZU XI YU, UNGER, E. F, EPSTEIN, S. E

“…Epidemiologic and mechanistic evidence implicates a role for cytomegalovirus (CMV) in atherogenesis. Recently, we demonstrated that CMV has the capacity to…”
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Rabbit Ear Model of Injury-Induced Arterial Smooth Muscle Cell Proliferation: Kinetics, Reproducibility, and Implications by Banai, Shmuel, Shou, Matie, Correa, Rosaly, Jaklitsch, Michael T, Douek, Philippe C, Bonner, Robert F, Epstein, Stephen E, Unger, Ellis F

“…Recently, considerable interest has focused on the vascular smooth muscle cell (SMC) response to injury, particularly as it relates to restenosis after…”
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Basic fibroblast growth factor in patients with intermittent claudication: results of a phase I trial by Lazarous, Daisy F, Unger, Ellis F, Epstein, Stephen E, Stine, Annette, Arevalo, Josefino L, Chew, Emily Y, Quyyumi, Arshed A

“…OBJECTIVES This phase I study was designed to evaluate the safety, tolerability and pharmacokinetics of intra-arterial basic fibroblast growth factor (bFGF) in…”
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Extracardiac to coronary anastomoses support regional left ventricular function in dogs by Unger, E F, Shou, M, Sheffield, C D, Hodge, E, Jaye, M, Epstein, S E

“…Intramyocardial implantation of a systemic artery [the internal mammary artery (IMA)] causes angiogenesis, with formation of systemic to coronary anastomoses…”
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Neointimal proliferation in canine coronary arteries. A model of restenosis permitting local and continuous drug delivery by Scheinowitz, M, Shou, M, Banai, S, Gertz, S D, Lazarous, D F, Unger, E F

“…A number of experimental preparations have been used to elucidate the pathophysiology of restenosis after percutaneous transluminal coronary angioplasty;…”
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Comparative effects of basic fibroblast growth factor and vascular endothelial growth factor on coronary collateral development and the arterial response to injury by Lazarous, D F, Shou, M, Scheinowitz, M, Hodge, E, Thirumurti, V, Kitsiou, A N, Stiber, J A, Lobo, A D, Hunsberger, S, Guetta, E, Epstein, S E, Unger, E F

“…We have shown that the angiogenic peptides basic fibroblast growth factor (bFGF) and vascular endothelial growth factor (VEGF) enhance canine coronary…”
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A model to assess interventions to improve collateral blood flow: continuous administration of agents into the left coronary artery in dogs by Unger, E F, Banai, S, Shou, M, Jaklitsch, M, Hodge, E, Correa, R, Jaye, M, Epstein, S E

“…The aim was to develop an experimental model in which angiogenic growth factor(s) could be targeted locally to enhance myocardial collateral formation. A…”
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Experimental evaluation of coronary collateral development by UNGER, Ellis F

“…During the last decade, there has been great interest in the potential use of biologic agents and mechanical techniques to enhance myocardial collateral…”
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Creation of anastomoses between an extracardiac artery and the coronary circulation : proof that myocardial angiogenesis occurs and can provide nutritional blood flow to the myocardium by UNGER, E. F, SHEFFIELD, C. D, EPSTEIN, S. E

“…The purpose of this investigation was to determine whether blood vessels could develop de novo between an extracardiac artery and a collateral-dependent zone…”
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The Magnitude of Inotropic Reserve Is Unrelated to Basal Systolic Function or Wall Thickness in Patients With Chronic Ischemic Left Ventricular Dysfunction by Curiel, Rodolfo V, Laurienzo, Joy M, Unger, Ellis F, Panza, Julio A

“…Forty-four patients with coronary artery disease and left ventricular dysfunction underwent transesophageal echocardiography with dobutamine infusion to…”
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Adenoviral-mediated gene transfer induces sustained pericardial VEGF expression in dogs: effect on myocardial angiogenesis by Lazarous, D F, Shou, M, Stiber, J A, Hodge, E, Thirumurti, V, Gonçalves, L, Unger, E F

“…Angiogenic peptides like VEGF (vascular endothelial growth factor) and bFGF (basic fibroblast growth factor) have entered clinical trials for coronary artery…”
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