Search Results - "Unger, Andreas"

Myocardial Microvascular Inflammatory Endothelial Activation in Heart Failure With Preserved Ejection Fraction by Franssen, Constantijn, MD, Chen, Sophia, BSc, Unger, Andreas, PhD, Korkmaz, H. Ibrahim, MSc, De Keulenaer, Gilles W., MD, PhD, Tschöpe, Carsten, MD, PhD, Leite-Moreira, Adelino F., MD, PhD, Musters, René, PhD, Niessen, Hans W.M., MD, PhD, Linke, Wolfgang A., PhD, Paulus, Walter J., MD, PhD, Hamdani, Nazha, PhD

“…Abstract Objectives The present study investigated whether systemic, low-grade inflammation of metabolic risk contributed to diastolic left ventricular (LV)…”
Get full text

Human myocytes are protected from titin aggregation-induced stiffening by small heat shock proteins by Kötter, Sebastian, Unger, Andreas, Hamdani, Nazha, Lang, Patrick, Vorgerd, Matthias, Nagel-Steger, Luitgard, Linke, Wolfgang A

“…In myocytes, small heat shock proteins (sHSPs) are preferentially translocated under stress to the sarcomeres. The functional implications of this…”
Get full text

Protein phosphatase 5 regulates titin phosphorylation and function at a sarcomere-associated mechanosensor complex in cardiomyocytes by Krysiak, Judith, Unger, Andreas, Beckendorf, Lisa, Hamdani, Nazha, von Frieling-Salewsky, Marion, Redfield, Margaret M., dos Remedios, Cris G., Sheikh, Farah, Gergs, Ulrich, Boknik, Peter, Linke, Wolfgang A.

“…Serine/threonine protein phosphatase 5 (PP5) is ubiquitously expressed in eukaryotic cells; however, its function in cardiomyocytes is unknown. Under basal…”
Get full text

Maintenance of sarcomeric integrity in adult muscle cells crucially depends on Z-disc anchored titin by Swist, Sandra, Unger, Andreas, Li, Yong, Vöge, Anja, von Frieling-Salewsky, Marion, Skärlén, Åsa, Cacciani, Nicola, Braun, Thomas, Larsson, Lars, Linke, Wolfgang A.

“…The giant protein titin is thought to be required for sarcomeric integrity in mature myocytes, but direct evidence for this hypothesis is limited. Here, we…”
Get full text

A HaloTag-TEV genetic cassette for mechanical phenotyping of proteins from tissues by Rivas-Pardo, Jaime Andrés, Li, Yong, Mártonfalvi, Zsolt, Tapia-Rojo, Rafael, Unger, Andreas, Fernández-Trasancos, Ángel, Herrero-Galán, Elías, Velázquez-Carreras, Diana, Fernández, Julio M., Linke, Wolfgang A., Alegre-Cebollada, Jorge

“…Single-molecule methods using recombinant proteins have generated transformative hypotheses on how mechanical forces are generated and sensed in biological…”
Get full text

Protonation of Piezo1 Impairs Cell-Matrix Interactions of Pancreatic Stellate Cells by Kuntze, Anna, Goetsch, Ole, Fels, Benedikt, Najder, Karolina, Unger, Andreas, Wilhelmi, Marianne, Sargin, Sarah, Schimmelpfennig, Sandra, Neumann, Ilka, Schwab, Albrecht, Pethő, Zoltan

“…Pancreatic ductal adenocarcinoma (PDAC) is characterized by an acidic and fibrotic stroma. The extracellular matrix (ECM) causing the fibrosis is primarily…”
Get full text

Smyd2 controls cytoplasmic lysine methylation of Hsp90 and myofilament organization by Donlin, Laura T, Andresen, Christian, Just, Steffen, Rudensky, Eugene, Pappas, Christopher T, Kruger, Martina, Jacobs, Erica Y, Unger, Andreas, Zieseniss, Anke, Dobenecker, Marc-Werner, Voelkel, Tobias, Chait, Brian T, Gregorio, Carol C, Rottbauer, Wolfgang, Tarakhovsky, Alexander, Linke, Wolfgang A

“…Protein lysine methylation is one of the most widespread post-translational modifications in the nuclei of eukaryotic cells. Methylated lysines on histones and…”
Get full text

Graded titin cleavage progressively reduces tension and uncovers the source of A-band stability in contracting muscle by Li, Yong, Hessel, Anthony L, Unger, Andreas, Ing, David, Recker, Jannik, Koser, Franziska, Freundt, Johanna K, Linke, Wolfgang A

“…The giant muscle protein titin is a major contributor to passive force; however, its role in active force generation is unresolved. Here, we use a novel…”
Get full text

Syndecan-4 is a key determinant of collagen cross-linking and passive myocardial stiffness in the pressure-overloaded heart by Herum, Kate M, Lunde, Ida G, Skrbic, Biljana, Louch, William E, Hasic, Almira, Boye, Sigurd, Unger, Andreas, Brorson, Sverre-Henning, Sjaastad, Ivar, Tønnessen, Theis, Linke, Wolfgang A, Gomez, Maria F, Christensen, Geir

“…Diastolic dysfunction is central to the development of heart failure. To date, there is no effective treatment and only limited understanding of its molecular…”
Get full text

Microscopic and Biochemical Hallmarks of BICD2 -Associated Muscle Pathology toward the Evaluation of Novel Variants by Unger, Andreas, Roos, Andreas, Gangfuß, Andrea, Hentschel, Andreas, Gläser, Dieter, Krause, Karsten, Doering, Kristina, Schara-Schmidt, Ulrike, Hoffjan, Sabine, Vorgerd, Matthias, Güttsches, Anne-Katrin

“…variants have been linked to neurodegenerative disorders like spinal muscular atrophy with lower extremity predominance (SMALED2) or hereditary spastic…”
Get full text

High‐dose tamoxifen and sulindac as first‐line treatment for desmoid tumors by Hansmann, Anika, Adolph, Claudia, Vogel, Tilmann, Unger, Andreas, Moeslein, Gabriela

“…BACKGROUND Desmoid tumors are mesenchymal nonmetastasizing neoplasms. Although rare in the general population, they are a common extracolonic manifestation of…”
Get full text

An isoform of the giant protein titin is a master regulator of human T lymphocyte trafficking by Toffali, Lara, D’Ulivo, Beatrice, Giagulli, Cinzia, Montresor, Alessio, Zenaro, Elena, Delledonne, Massimo, Rossato, Marzia, Iadarola, Barbara, Sbarbati, Andrea, Bernardi, Paolo, Angelini, Gabriele, Rossi, Barbara, Lopez, Nicola, Linke, Wolfgang A., Unger, Andreas, Di Silvestre, Dario, Benazzi, Louise, De Palma, Antonella, Motta, Sara, Constantin, Gabriela, Mauri, Pierluigi, Laudanna, Carlo

“…Response to multiple microenvironmental cues and resilience to mechanical stress are essential features of trafficking leukocytes. Here, we describe unexpected…”
Get full text

Role for Reelin in neurotransmitter release by Hellwig, Sabine, Hack, Iris, Kowalski, Janina, Brunne, Bianka, Jarowyj, Joel, Unger, Andreas, Bock, Hans H, Junghans, Dirk, Frotscher, Michael

“…The extracellular matrix molecule Reelin is known to control neuronal migration during development. Recent evidence suggests that it also plays a role in the…”
Get full text

A novel isoform of myosin 18A (Myo18Aγ) is an essential sarcomeric protein in mouse heart by Horsthemke, Markus, Nutter, Lauryl M.J., Bachg, Anne C., Skryabin, Boris V., Honnert, Ulrike, Zobel, Thomas, Bogdan, Sven, Stoll, Monika, Seidl, Matthias D., Müller, Frank U., Ravens, Ursula, Unger, Andreas, Linke, Wolfgang A., van Gorp, Pim R.R., de Vries, Antoine A.F., Bähler, Martin, Hanley, Peter J.

“…Whereas myosin 18B (Myo18B) is known to be a critical sarcomeric protein, the function of myosin 18A (Myo18A) is unclear, although it has been implicated in…”
Get full text

Engineered skeletal muscle recapitulates human muscle development, regeneration and dystrophy by Shahriyari, Mina, Islam, Md Rezaul, Sakib, Sadman M., Rinn, Malte, Rika, Anastasia, Krüger, Dennis, Kaurani, Lalit, Gisa, Verena, Winterhoff, Mandy, Anandakumar, Harithaa, Shomroni, Orr, Schmidt, Matthias, Salinas, Gabriela, Unger, Andreas, Linke, Wolfgang A., Zschüntzsch, Jana, Schmidt, Jens, Bassel‐Duby, Rhonda, Olson, Eric N., Fischer, André, Zimmermann, Wolfram‐Hubertus, Tiburcy, Malte

“…Background Human pluripotent stem cell‐derived muscle models show great potential for translational research. Here, we describe developmentally inspired…”
Get full text

Overexpression of human BAG3P209L in mice causes restrictive cardiomyopathy by Kimura, Kenichi, Ooms, Astrid, Graf-Riesen, Kathrin, Kuppusamy, Maithreyan, Unger, Andreas, Schuld, Julia, Daerr, Jan, Lother, Achim, Geisen, Caroline, Hein, Lutz, Takahashi, Satoru, Li, Guang, Röll, Wilhelm, Bloch, Wilhelm, van der Ven, Peter F. M., Linke, Wolfgang A., Wu, Sean M., Huesgen, Pitter F., Höhfeld, Jörg, Fürst, Dieter O., Fleischmann, Bernd K., Hesse, Michael

“…An amino acid exchange (P209L) in the HSPB8 binding site of the human co-chaperone BAG3 gives rise to severe childhood cardiomyopathy. To phenocopy the disease…”
Get full text

Membrane Remodeling by a Bacterial Phospholipid-Methylating Enzyme by Danne, Linna, Aktas, Meriyem, Unger, Andreas, Linke, Wolfgang A, Erdmann, Ralf, Narberhaus, Franz

“…Membrane deformation by proteins is a universal phenomenon that has been studied extensively in eukaryotes but much less in prokaryotes. In this study, we…”
Get full text

Translocation of molecular chaperones to the titin springs is common in skeletal myopathy patients and affects sarcomere function by Unger, Andreas, Beckendorf, Lisa, Böhme, Pierre, Kley, Rudolf, von Frieling-Salewsky, Marion, Lochmüller, Hanns, Schröder, Rolf, Fürst, Dieter O, Vorgerd, Matthias, Linke, Wolfgang A

“…Myopathies encompass a wide variety of acquired and hereditary disorders. The pathomechanisms include structural and functional changes affecting, e.g.,…”
Get full text

Homozygous expression of the myofibrillar myopathy-associated p.W2710X filamin C variant reveals major pathomechanisms of sarcomeric lesion formation by Schuld, Julia, Orfanos, Zacharias, Chevessier, Frédéric, Eggers, Britta, Heil, Lorena, Uszkoreit, Julian, Unger, Andreas, Kirfel, Gregor, van der Ven, Peter F. M, Marcus, Katrin, Linke, Wolfgang A, Clemen, Christoph S, Schröder, Rolf, Fürst, Dieter O

“…Abstract Filamin C (FLNc) is mainly expressed in striated muscle cells where it localizes to Z-discs, myotendinous junctions and intercalated discs. Recent…”
Get full text

Novel Filamin C Myofibrillar Myopathy Variants Cause Different Pathomechanisms and Alterations in Protein Quality Systems by Sellung, Dominik, Heil, Lorena, Daya, Nassam, Jacobsen, Frank, Mertens-Rill, Janine, Zhuge, Heidi, Döring, Kristina, Piran, Misagh, Milting, Hendrik, Unger, Andreas, Linke, Wolfgang A, Kley, Rudi, Preusse, Corinna, Roos, Andreas, Fürst, Dieter O, Ven, Peter F M van der, Vorgerd, Matthias

“…Myofibrillar myopathies (MFM) are a group of chronic muscle diseases pathophysiologically characterized by accumulation of protein aggregates and structural…”
Get full text