Search Results - "Unge, T."

Synthesis and Comparative Molecular Field Analysis (CoMFA) of Symmetric and Nonsymmetric Cyclic Sulfamide HIV-1 Protease Inhibitors by Schaal, Wesley, Karlsson, Anna, Ahlsén, Göran, Lindberg, Jimmy, Andersson, Hans O, Danielson, U. Helena, Classon, Björn, Unge, Torsten, Samuelsson, Bertil, Hultén, Johan, Hallberg, Anders, Karlén, Anders

“…We have previously reported on the unexpected flipped conformation in the cyclic sulfamide class of inhibitors. An attempt to induce a symmetric binding…”
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The VIZIER project: Preparedness against pathogenic RNA viruses by Coutard, B., Gorbalenya, A.E., Snijder, E.J., Leontovich, A.M., Poupon, A., De Lamballerie, X., Charrel, R., Gould, E.A., Gunther, S., Norder, H., Klempa, B., Bourhy, H., Rohayem, J., L’hermite, E., Nordlund, P., Stuart, D.I., Owens, R.J., Grimes, J.M., Tucker, P.A., Bolognesi, M., Mattevi, A., Coll, M., Jones, T.A., Åqvist, J., Unge, T., Hilgenfeld, R., Bricogne, G., Neyts, J., La Colla, P., Puerstinger, G., Gonzalez, J.P., Leroy, E., Cambillau, C., Romette, J.L., Canard, B.

“…Life-threatening RNA viruses emerge regularly, and often in an unpredictable manner. Yet, the very few drugs available against known RNA viruses have sometimes…”
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Application of the use of high-throughput technologies to the determination of protein structures of bacterial and viral pathogens by Fogg, M. J., Bahar, M., Alzari, P., Bertini, I., Betton, J.-M., Burmeister, W. P., Cambillau, C., Coll, M., Canard, B., Carrondo, M., Daenke, S., Dym, O., Geerlof, A., Egloff, M.-P., Haouz, A., Enguita, F. J., Jones, T. A., Ma, Qingjun, Manicka, S. N., Owens, R.J., Migliardi, M., Nordlund, P., Peleg, Y., Schneider, G., Schnell, R., Stuart, D. I., Unge, T., Tarbouriech, N., Wilkinson, A. J., Wilmanns, M., Wilson, K. S., Zimhony, O., Grimes, J. M.

“…The Structural Proteomics In Europe (SPINE) programme is aimed at the development and implementation of high‐throughput technologies for the efficient…”
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Symmetric fluoro-substituted diol-based HIV protease inhibitors. Ortho-fluorinated and meta-fluorinated P1/P1'-benzyloxy side groups significantly improve the antiviral activity and preserve binding efficacy by Lindberg, Jimmy, Pyring, David, Löwgren, Seved, Rosenquist, Asa, Zuccarello, Guido, Kvarnström, Ingemar, Zhang, Hong, Vrang, Lotta, Classon, Björn, Hallberg, Anders, Samuelsson, Bertil, Unge, Torsten

“…HIV-1 protease is a pivotal enzyme in the later stages of the viral life cycle which is responsible for the processing and maturation of the virus particle…”
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Optimization of P1–P3 groups in symmetric and asymmetric HIV‐1 protease inhibitors by Andersson, Hans O., Fridborg, Kerstin, Löwgren, Seved, Alterman, Mathias, Mühlman, Anna, Björsne, Magnus, Garg, Neeraj, Kvarnström, Ingmar, Schaal, Wesley, Classon, Björn, Karlén, Anders, Danielsson, U. Helena, Ahlsén, Göran, Nillroth, Ullrika, Vrang, Lotta, Öberg, Bo, Samuelsson, Bertil, Hallberg, Anders, Unge, Torsten

“…HIV‐1 protease is an important target for treatment of AIDS, and efficient drugs have been developed. However, the resistance and negative side effects of the…”
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The three‐dimensional structure of P2 myelin protein by Jones, T. A., Bergfors, T., Sedzik, J., Unge, T.

“…The three‐dimensional structure of P2 protein from peripheral nervous system myelin has been determined at 2.7 A resolution by X‐ray crystallography. The…”
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Human Immunodeficiency Virus Type 1 Central DNA Flap: Dynamic Terminal Product of Plus-Strand Displacement DNA Synthesis Catalyzed by Reverse Transcriptase Assisted by Nucleocapsid Protein by Hameau, L, Jeusset, J, Lafosse, S, Coulaud, D, Delain, E, Unge, T, Restle, T, Le Cam, E, Mirambeau, G

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Synthesis of Novel, Potent, Diol-Based HIV-1 Protease Inhibitors via Intermolecular Pinacol Homocoupling of (2S)-2-Benzyloxymethyl-4-phenylbutanal by Mühlman, Anna, Lindberg, Jimmy, Classon, Björn, Unge, Torsten, Hallberg, Anders, Samuelsson, Bertil

“…The synthesis of novel, potent, diol-based HIV-1 protease inhibitors, having phenethyl groups (−CH2CH2Ph) in P1/P1‘ position is described. An intermolecular…”
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Human Immunodeficiency Virus Type 1 (HIV-1) Strains Selected for Resistance Against the HIV-1-Specific [2',5'-Bis-O-(Tert-Butyldimethylsilyl)-3'- Spiro-5''-(4''-Amino-1'',2''-Oxathiole-2'',2''-Dioxide)]-β-D- Pentofuranosyl (TSAO) Nucleoside Analogues Retain Sensitivity to HIV-1- Specific Nonnucleoside Inhibitors by Balzarini, J., Karlsson, A., A.-M. Vandamme, M.-J. Perez-Perez, Zhang, H., Vrang, L., Oberg, B., Backbro, K., Unge, T., San-Felix, A., Velazquez, s., M.-J. Camarasa, De Clercq, E.

“…We recently reported that a newly discovered class of nucleoside analogues-[2',5'-bis-O-(tert-butyldimethylsilyl)-3'-spiro-5"-(4"-amino-1",…”
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The Rex Regulatory Protein of Human T-Cell Lymphotropic Virus Type I Binds Specifically to Its Target Site within the Viral RNA by Unge, Torsten, Solomin, Ludmila, Mellini, Michael, Derse, David, Felber, Barbara K., Pavlakis, George N.

“…The Rex protein of human T-cell leukemia virus type I (HTLV-I) was expressed in bacteria and partially purified. Rex was shown to bind in vitro specifically to…”
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Monoclonal antibodies to native HIV type 1 reverse transcriptase and their interaction with enzymes from different subtypes by Rytting, A S, Akerblom, L, Albert, J, Unge, T, Björling, E, Al-Khalili, L, Gronowitz, J S, Källander, C F

“…Recombinant reverse transcriptase (RT) from HIV-1 subtype B was used to produce mouse anti-RT monoclonal antibodies (MAbs). Immunization was done by mixing RT…”
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Application of the use of high-throughput technologies to the determination of protein structures of bacterial and viral pathogens. Corrigendum by Fogg, M. J., Alzari, P., Bahar, M., Bertini, I., Betton, J.-M., Burmeister, W. P., Cambillau, C., Canard, B., Carrondo, M. A., Coll, M., Daenke, S., Dym, O., Egloff, M.-P., Enguita, F. J., Geerlof, A., Haouz, A., Jones, T. A., Ma, Qingjun, Manicka, S. N., Migliardi, M., Nordlund, P., Owens, R. J., Peleg, Y., Schneider, G., Schnell, R., Stuart, D. I., Tarbouriech, N., Unge, T., Wilkinson, A. J., Wilmanns, M., Wilson, K. S., Zimhony, O., Grimes, J. M.

“…A correction is made to the name of one of the authors in Fogg et al. (2006), Acta Cryst. D62, 11961207…”
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Structure determination of the bacteriophage MS2 by Valegård, K, Liljas, L, Fridborg, K, Unge, T

“…The structure of the bacterial virus MS2 has been solved at 3.3 A resolution. Initial phases to 13 A resolution were obtained from a model based on the known…”
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Structure and Function of Carbonic Anhydrases from Mycobacterium tuberculosis by Covarrubias, Adrian Suarez, Larsson, Anna M., Högbom, Martin, Lindberg, Jimmy, Bergfors, Terese, Björkelid, Christofer, Mowbray, Sherry L., Unge, Torsten, Jones, T. Alwyn

“…Carbonic anhydrases catalyze the reversible hydration of carbon dioxide to form bicarbonate. This activity is universally required for fatty acid biosynthesis…”
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Interaction Kinetic Characterization of HIV-1 Reverse Transcriptase Non-nucleoside Inhibitor Resistance by Geitmann, Matthis, Unge, Torsten, Danielson, U. Helena

“…To decipher the mechanism for non-nucleoside inhibitor resistance of HIV-1 reverse transcriptase, the kinetics of the interaction between wild type and…”
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Crystal structures of HIV-1 reverse transcriptase complexes with thiocarbamate non-nucleoside inhibitors by Spallarossa, Andrea, Cesarini, Sara, Ranise, Angelo, Ponassi, Marco, Unge, Torsten, Bolognesi, Martino

“…O-Phthalimidoethyl- N-arylthiocarbamates (TCs) have been recently identified as a new class of potent HIV-1 reverse transcriptase (RT) non-nucleoside…”
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Biosensor-Based Kinetic Characterization of the Interaction between HIV-1 Reverse Transcriptase and Non-nucleoside Inhibitors by Geitmann, Matthis, Unge, Torsten, Danielson, U. Helena

“…Details of the interaction between HIV-1 reverse transcriptase and non-nucleoside inhibitors (NNRTIs) have been elucidated using a biosensor-based approach…”
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Immunological Characterization Of The Human Immunodeficiency Virus Type 1 Reverse Transcriptase Protein By The Use Of Monoclonal Antibodies by Orvell, Claes, Unge, Torsten, Bhikhabhai, Ramagauri, Backbro, Kristina, Ruden, Ulla, Strandberg, Bror, Wahren, Britta, Fenyo, Eva Maria

“…1 Department of Virology, National Bacteriological Laboratory, S-105 21 Stockholm 2 Department of Virology, Karolinska Institute, S-105 21 Stockholm and 3…”
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Human immunodeficiency virus type 1 (HIV-1) strains selected for resistance against the HIV-1-specific [2',5'-bis-O-(tert-butyldimethylsilyl)-3'-spiro- 5''-(4''-amino-1'',2''-oxathiole-2'',2''-dioxide)]-beta-D-pentofurano syl (TSAO) nucleoside analogues retain sensitivity to HIV-1-specific nonnucleoside inhibitors by Balzarini, J, Karlsson, A, Vandamme, A M, Pérez-Pérez, M J, Zhang, H, Vrang, L, Oberg, B, Bäckbro, K, Unge, T, San-Félix, A

“…We recently reported that a newly discovered class of nucleoside analogues--[2',5'-bis-O-(tert-butyldimethylsilyl)-…”
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Evidence for a Mechanism of Recombination during Reverse Transcription Dependent on the Structure of the Acceptor RNA by Moumen, Abdeladim, Polomack, Lucette, Unge, Torsten, Véron, Michel, Buc, Henri, Negroni, Matteo

“…Genetic recombination is a major force driving retroviral evolution. In retroviruses, recombination proceeds mostly through copy choice during reverse…”
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