Search Results - "Ung, Matthew H"

Computational Investigation of Homologous Recombination DNA Repair Deficiency in Sporadic Breast Cancer by Wang, Yue, Ung, Matthew H., Cantor, Sharon, Cheng, Chao

“…BRCAness has important implications in the management and treatment of patients with breast and ovarian cancer. In this study, we propose a computational…”
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The E2F4 prognostic signature predicts pathological response to neoadjuvant chemotherapy in breast cancer patients by Mark, Kenneth M K, Varn, Frederick S, Ung, Matthew H, Qian, Feng, Cheng, Chao

“…Neoadjuvant chemotherapy is a key component of breast cancer treatment regimens and pathologic complete response to this therapy varies among patients. This is…”
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Regulators associated with clinical outcomes revealed by DNA methylation data in breast cancer by Ung, Matthew H, Varn, Frederick S, Lou, Shaoke, Cheng, Chao

“…The regulatory architecture of breast cancer is extraordinarily complex and gene misregulation can occur at many levels, with transcriptional malfunction being…”
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Application of RNAi-induced gene expression profiles for prognostic prediction in breast cancer by Wang, Yue, Mark, Kenneth M K, Ung, Matthew H, Kettenbach, Arminja, Miller, Todd, Xu, Wei, Cheng, Wenqing, Xia, Tian, Cheng, Chao

“…Homologous recombination (HR) is the primary pathway for repairing double-strand DNA breaks implicating in the development of cancer. RNAi-based knockdowns of…”
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Protein mistranslation protects bacteria against oxidative stress by Fan, Yongqiang, Wu, Jiang, Ung, Matthew H, De Lay, Nicholas, Cheng, Chao, Ling, Jiqiang

“…Accurate flow of genetic information from DNA to protein requires faithful translation. An increased level of translational errors (mistranslation) has…”
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MYC Mediates mRNA Cap Methylation of Canonical Wnt/β-Catenin Signaling Transcripts By Recruiting CDK7 and RNA Methyltransferase by Posternak, Valeriya, Ung, Matthew H, Cheng, Chao, Cole, Michael D

“…MYC is a pleiotropic transcription factor that activates and represses a wide range of target genes and is frequently deregulated in human tumors. While much…”
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Statins associate with improved mortality among patients with certain histological subtypes of lung cancer by Ung, Matthew H., MacKenzie, Todd A., Onega, Tracy L., Amos, Christopher I., Cheng, Chao

“…•This study investigates statin use and mortality risk among SEER-Medicare patients.•Patients with squamous-cell carcinoma or adenocarcinoma benefit from using…”
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Integrative analysis of cancer genes in a functional interactome by Ung, Matthew H., Liu, Chun-Chi, Cheng, Chao

“…The post-genomic era has resulted in the accumulation of high-throughput cancer data from a vast array of genomic technologies including next-generation…”
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Cancer cell line specific co-factors modulate the FOXM1 cistrome by Wang, Yue, Ung, Matthew H, Xia, Tian, Cheng, Wenqing, Cheng, Chao

“…ChIP-seq has been commonly applied to identify genomic occupation of transcription factors (TFs) in a context-specific manner. It is generally assumed that a…”
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Application of pharmacologically induced transcriptomic profiles to interrogate PI3K-Akt-mTOR pathway activity associated with cancer patient prognosis by Ung, Matthew H, Wang, George L, Varn, Frederick S, Cheng, Chao

“…The PI3K-Akt-mTOR signaling pathway has been identified as a key driver of carcinogenesis in several cancer types. As such, a major area of focus in cancer…”
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Integrative Genomic Analyses Yield Cell-Cycle Regulatory Programs with Prognostic Value by Cheng, Chao, Lou, Shaoke, Andrews, Erik H, Ung, Matthew H, Varn, Frederick S

“…Liposarcoma is the second most common form of sarcoma, which has been categorized into four molecular subtypes, which are associated with differential…”
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In silico frameworks for systematic pre-clinical screening of potential anti-leukemia therapeutics by Ung, Matthew H, Varn, Frederick S, Cheng, Chao

“…Leukemia is a collection of highly heterogeneous cancers that arise from neoplastic transformation and clonal expansion of immature hematopoietic cells…”
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Integrative analysis of survival-associated gene sets in breast cancer by Varn, Frederick S, Ung, Matthew H, Lou, Shao Ke, Cheng, Chao

“…Patient gene expression information has recently become a clinical feature used to evaluate breast cancer prognosis. The emergence of prognostic gene sets that…”
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Statins associated with improved mortality among patients with certain histological subtypes of lung cancer by Ung, Matthew H., MacKenzie, Todd A., Onega, Tracy L., Amos, Christopher I., Cheng, Chao

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Regulators Associated with Clinical Outcomes Revealed by DNA Methylation Data in Breast Cancer: e1004269 by Ung, Matthew H, Varn, Frederick S, Lou, Shaoke, Cheng, Chao

“…The regulatory architecture of breast cancer is extraordinarily complex and gene misregulation can occur at many levels, with transcriptional malfunction being…”
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Abstract 5009: Self-renewal of hypoxic glioma stem-like cells is facilitated by secretion-mediated STAT3 activation by Bonnin, Damian A. Almiron, Havrda, Matthew C., Liu, Huan, Lee, Myung Chang, Ung, Matthew H., Cheng, Chao, Israel, Mark A.

“…Abstract Glioblastoma, a type of high-grade glioma, is the most common and the most aggressive primary brain tumor of adults. The median survival is 12-15…”
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Integrative Genomic Analyses Yields Cell Cycle Regulatory Programs with Prognostic Value by Cheng, Chao, Lou, Shaoke, Andrews, Erik H., Ung, Matthew H., Varn, Frederick S.

“…Liposarcoma is the second most common form of sarcoma, which has been categorized into four molecular subtypes, which are associated with differential…”
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Integration and Analysis of Biodata Compendia: Informatics Approaches for Cancer Drug Discovery by Ung, Matthew H

“…The Information Age has introduced a deluge of biological and biomedical data generated by academic multi-institutional consortia, healthcare and government…”
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Integrated Drug Expression Analysis for leukemia: an integrated in silico and in vivo approach to drug discovery by Ung, M H, Sun, C-H, Weng, C-W, Huang, C-C, Lin, C-C, Liu, C-C, Cheng, C

“…Screening for drug compounds that exhibit therapeutic properties in the treatment of various diseases remains a challenge even after considerable advancements…”
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