Search Results - "Uney, James B."

Axotomy-induced miR-21 promotes axon growth in adult dorsal root ganglion neurons by Strickland, Iain T, Richards, Louise, Holmes, Fiona E, Wynick, David, Uney, James B, Wong, Liang-Fong

“…Following injury, dorsal root ganglion (DRG) neurons undergo transcriptional changes so as to adopt phenotypic changes that promote cell survival and axonal…”
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Separate elements of episodic memory subserved by distinct hippocampal–prefrontal connections by Barker, Gareth R I, Banks, Paul J, Scott, Hannah, Ralph, G Scott, Mitrophanous, Kyriacos A, Wong, Liang-Fong, Bashir, Zafar I, Uney, James B, Warburton, E Clea

“…Episodic memory involves encoding an event's temporal and spatial context. The authors show that temporal information is mediated by a direct projection from…”
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miR-186 Inhibits Muscle Cell Differentiation through Myogenin Regulation by Antoniou, Antonis, Mastroyiannopoulos, Nikolaos P., Uney, James B., Phylactou, Leonidas A.

“…The complex process of skeletal muscle differentiation is organized by the myogenic regulatory factors (MRFs), Myf5, MyoD, Myf6, and myogenin, where myogenin…”
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Expression of miR-1, miR-133a, miR-133b and miR-206 increases during development of human skeletal muscle by Koutsoulidou, Andrie, Mastroyiannopoulos, Nikolaos P, Furling, Denis, Uney, James B, Phylactou, Leonidas A

“…MicroRNAs (miRNAs) are small RNA molecules that post-transcriptionally regulate gene expression and have been shown to play an important role during…”
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AZD5438 a GSK-3a/b and CDK inhibitor is antiapoptotic modulates mitochondrial activity and protects human neurons from mitochondrial toxins by Shi, Gongyu, Scott, Helen, Azhar, Nur Izzah Farhana Mohamad, Gialeli, Andriana, Clennell, Benjamin, Lee, Keng Siang, Hurcombe, Jenny, Whitcomb, Daniel, Coward, Richard, Wong, Liang-Fong, Cordero-Llana, Oscar, Uney, James B.

“…We previously reported that kenpaullone, which inhibits GSK-3a/b and CDKs inhibited CCCP mediated mitochondrial depolarisation and augments the mitochondrial…”
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CREB Transcription in the Medial Prefrontal Cortex Regulates the Formation of Long-Term Associative Recognition Memory by Barker, Gareth Robert, Wong, Liang Fong, Uney, James B, Warburton, Elizabeth C

“…The medial prefrontal cortex (mPFC) is known to be critical for specific forms of long-term recognition memory, however the cellular mechanisms in the mPFC…”
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MicroRNA-132 regulates recognition memory and synaptic plasticity in the perirhinal cortex by Scott, Helen L., Tamagnini, Francesco, Narduzzo, Katherine E., Howarth, Joanna L., Lee, Youn-Bok, Wong, Liang-Fong, Brown, Malcolm W., Warburton, Elizabeth C., Bashir, Zafar I., Uney, James B.

“…Evidence suggests that the acquisition of recognition memory depends upon CREB‐dependent long‐lasting changes in synaptic plasticity in the perirhinal…”
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Down-regulation of myogenin can reverse terminal muscle cell differentiation by Mastroyiannopoulos, Nikolaos P, Nicolaou, Paschalis, Anayasa, Mustafa, Uney, James B, Phylactou, Leonidas A

“…Certain higher vertebrates developed the ability to reverse muscle cell differentiation (dedifferentiation) as an additional mechanism to regenerate muscle…”
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MiR-3120 Is a Mirror MicroRNA That Targets Heat Shock Cognate Protein 70 and Auxilin Messenger RNAs and Regulates Clathrin Vesicle Uncoating by Scott, Helen, Howarth, Joanna, Lee, Youn Bok, Wong, Liang-Fong, Bantounas, Ioannis, Phylactou, Leonidas, Verkade, Paul, Uney, James. B.

“…We show that a single gene locus gives rise to two fully processed and functional miRNAs, i.e. that due to imperfect base pairing, two distinct microRNAs…”
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Human Mesenchymal Stem Cells Infiltrate the Spinal Cord, Reduce Demyelination, and Localize to White Matter Lesions in Experimental Autoimmune Encephalomyelitis by Gordon, David, Pavlovska, Gordana, Uney, James B, Wraith, David C, Scolding, Neil J

“…Mesenchymal stem cells (MSCs) can abrogate the animal model ofmultiple sclerosis, experimental autoimmune encephalomyelitis (EAE), but whether this therapeutic…”
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Connexin 36 expression regulates neuronal differentiation from neural progenitor cells by Hartfield, Elizabeth M, Rinaldi, Federica, Glover, Colin P, Wong, Liang-Fong, Caldwell, Maeve A, Uney, James B

“…Gap junction communication has been shown in glial and neuronal cells and it is thought they mediate inter- and intra-cellular communication. Connexin 36…”
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Using viral vectors as gene transfer tools (Cell Biology and Toxicology Special Issue: ETCS-UK 1 day meeting on genetic manipulation of cells) by Howarth, Joanna L, Lee, Youn Bok, Uney, James B

“…In recent years, the development of powerful viral gene transfer techniques has greatly facilitated the study of gene function. This review summarises some of…”
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Twist reverses muscle cell differentiation through transcriptional down-regulation of myogenin by Mastroyiannopoulos, Nikolaos P, Antoniou, Antonis A, Koutsoulidou, Andrie, Uney, James B, Phylactou, Leonidas A

“…Some higher vertebrates can display unique muscle regenerative abilities through dedifferentiation. Research evidence suggests that induced dedifferentiation…”
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Differential patterning of neuronal, glial and neural progenitor cells on phosphorus-doped and UV irradiated diamond-like carbon by Regan, Edward M, Uney, James B, Dick, Andrew D, Zhang, Yiwei, Nunez-Yanez, Jose, McGeehan, Joseph P, Claeyssens, Frederik, Kelly, Stephen

“…Abstract Diamond-like carbon (DLC) is an attractive biomaterial for coating human implantable devices. Our particular research interest is in developing DLC as…”
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The application of ribozymes and DNAzymes in muscle and brain by Mastroyiannopoulos, Nikolaos P, Uney, James B, Phylactou, Leonidas A

“…The discovery of catalytic nucleic acids (CNAs) has provided scientists with valuable tools for the identification of new therapies for several untreated…”
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Surface expression of AMPA receptors in hippocampal neurons is regulated by an NSF-dependent mechanism by Noel, J, Ralph, G S, Pickard, L, Williams, J, Molnar, E, Uney, J B, Collingridge, G L, Henley, J M

“…Here, we show that disruption of N-ethylmaleimide-sensitive fusion protein- (NSF-) GluR2 interaction by infusion into cultured hippocampal neurons of a…”
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Arteriolar Genesis and Angiogenesis Induced by Endothelial Nitric Oxide Synthase Overexpression Results in a Mature Vasculature by Benest, Andrew V, Stone, Oliver A, Miller, William H, Glover, Colin P, Uney, James B, Baker, Andrew H, Harper, Steven J, Bates, David O

“…BACKGROUND—Generation of physiologically active vascular beds by delivery of combinations of growth factors offers promise for vascular gene therapy. METHODS…”
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Loss of MicroRNA-7 Regulation Leads to α-Synuclein Accumulation and Dopaminergic Neuronal Loss In Vivo by McMillan, Kirsty J., Murray, Tracey K., Bengoa-Vergniory, Nora, Cordero-Llana, Oscar, Cooper, Jane, Buckley, Amy, Wade-Martins, Richard, Uney, James B., O’Neill, Michael J., Wong, Liang F., Caldwell, Maeve A.

“…Abnormal alpha-synuclein (α-synuclein) expression and aggregation is a key characteristic of Parkinson’s disease (PD). However, the exact mechanism(s) linking…”
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SAFB re-distribution marks steps of the apoptotic process by Lee, Youn-Bok, Colley, Shane, Norman, Michel, Biamonti, Giuseppe, Uney, James B.

“…We have found novel functions of scaffold attachment factor-B1 (SAFB) during apoptosis. The experiments showed that SAFB moved into the nucleolus 15 min after…”
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MicroRNAs and Osmotic Regulation by Uney, James B., Lightman, Stafford L.

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