Search Results - "Unekawa, Miyuki"

Cortical spreading depolarisation-induced facial hyperalgesia, photophobia and hypomotility are ameliorated by sumatriptan and olcegepant by Tang, Chunhua, Unekawa, Miyuki, Kitagawa, Satoshi, Takizawa, Tsubasa, Kayama, Yohei, Nakahara, Jin, Shibata, Mamoru

“…Cortical spreading depolarisation (CSD), the neural mechanism underlying migraine aura, may cause headache by sensitising the trigeminal system. Photophobia,…”
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Differential pial and penetrating arterial responses examined by optogenetic activation of astrocytes and neurons by Hatakeyama, Nao, Unekawa, Miyuki, Murata, Juri, Tomita, Yutaka, Suzuki, Norihiro, Nakahara, Jin, Takuwa, Hiroyuki, Kanno, Iwao, Matsui, Ko, Tanaka, Kenji F, Masamoto, Kazuto

“…A variety of brain cells participates in neurovascular coupling by transmitting and modulating vasoactive signals. The present study aimed to probe cell…”
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Close association between spreading depolarization and development of infarction under experimental ischemia in anesthetized male mice by Unekawa, Miyuki, Tomita, Yutaka, Masamoto, Kazuto, Kanno, Iwao, Nakahara, Jin, Izawa, Yoshikane

“…[Display omitted] •No infarct was detected in mice without SD during experimental ischemia.•The infarct size tended to be larger in repeated SD-occurred…”
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Effect of Goreisan, a Japanese Traditional Medicine, on Cortical Spreading Depolarization in Mice by Iba, Chisato, Unekawa, Miyuki, Izawa, Yoshikane, Nakahara, Jin, Takizawa, Tsubasa

“…Goreisan, a traditional Japanese Kampo medicine, is often used to treat headaches, including migraines; however, the underlying mechanisms remain unknown…”
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Sustained Effects of CGRP Blockade on Cortical Spreading Depolarization-Induced Alterations in Facial Heat Pain Threshold, Light Aversiveness, and Locomotive Activity in the Light Environment by Kitagawa, Satoshi, Tang, Chunhua, Unekawa, Miyuki, Kayama, Yohei, Nakahara, Jin, Shibata, Mamoru

“…A migraine is clinically characterized by repeated headache attacks that entail considerable disability. Many patients with migraines experience postdrome, the…”
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Calcitonin Gene-Related Peptide mRNA Synthesis in Trigeminal Ganglion Neurons after Cortical Spreading Depolarization by Shibata, Mamoru, Kitagawa, Satoshi, Unekawa, Miyuki, Takizawa, Tsubasa, Nakahara, Jin

“…Migraine is a debilitating neurovascular disorder characterized by recurrent headache attacks of moderate to severe intensity. Calcitonin gene-related peptide…”
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Separate optogenetic manipulation of Nerve/glial antigen 2 (NG2) glia and mural cells using the NG2 promoter by Oishi, Mitsuhiro, Passlick, Stefan, Yamazaki, Yoshihiko, Unekawa, Miyuki, Adachi, Ruka, Yamada, Mayumi, Imayoshi, Itaru, Abe, Yoshifumi, Steinhäuser, Christian, Tanaka, Kenji F.

“…Nerve/glial antigen 2 (NG2) is a protein marker of NG2 glia and mural cells, and NG2 promoter activity is utilized to target these cells. However, the NG2…”
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High-mobility group box 1 is an important mediator of microglial activation induced by cortical spreading depression by Takizawa, Tsubasa, Shibata, Mamoru, Kayama, Yohei, Shimizu, Toshihiko, Toriumi, Haruki, Ebine, Taeko, Unekawa, Miyuki, Koh, Anri, Yoshimura, Akihiko, Suzuki, Norihiro

“…Single episodes of cortical spreading depression (CSD) are believed to cause typical migraine aura, whereas clusters of spreading depolarizations have been…”
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Alterations in the threshold of the potassium concentration to evoke cortical spreading depression during the natural estrous cycle in mice by Ebine, Taeko, Toriumi, Haruki, Shimizu, Toshihiko, Unekawa, Miyuki, Takizawa, Tsubasa, Kayama, Yohei, Shibata, Mamoru, Suzuki, Norihiro

“…•This study explored the inducibility of CSD in the natural estrous cycle of mice.•Susceptibility to the development of CSD is elevated in the diestrus…”
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Optical manipulation of local cerebral blood flow in the deep brain of freely moving mice by Abe, Yoshifumi, Kwon, Soojin, Oishi, Mitsuhiro, Unekawa, Miyuki, Takata, Norio, Seki, Fumiko, Koyama, Ryuta, Abe, Manabu, Sakimura, Kenji, Masamoto, Kazuto, Tomita, Yutaka, Okano, Hideyuki, Mushiake, Hajime, Tanaka, Kenji F.

“…An artificial tool for manipulating local cerebral blood flow (CBF) is necessary for understanding how CBF controls brain function. Here, we generate vascular…”
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Dynamic diameter response of intraparenchymal penetrating arteries during cortical spreading depression and elimination of vasoreactivity to hypercapnia in anesthetized mice by Unekawa, Miyuki, Tomita, Yutaka, Masamoto, Kazuto, Toriumi, Haruki, Osada, Takashi, Kanno, Iwao, Suzuki, Norihiro

“…Cortical spreading depression (CSD) induces marked hyperemia with a transient decrease of regional cerebral blood flow (rCBF), followed by sustained oligemia…”
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Effects of passive smoking on cortical spreading depolarization in male and female mice by Takizawa, Tsubasa, Ihara, Keiko, Unekawa, Miyuki, Iba, Chisato, Kagawa, Shizuko, Watanabe, Narumi, Nakayama, Shingo, Sakurai, Kaori, Miyazaki, Naoki, Ishida, Noriyuki, Takemura, Ryo, Shibata, Mamoru, Izawa, Yoshikane, Chubachi, Shotaro, Fukunaga, Koichi, Nakahara, Jin

“…Background Patients with migraine are typically advised to avoid passive smoking because it may aggravate headaches and other health conditions. However, there…”
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In Vivo Imaging of the Mouse Neurovascular Unit Under Chronic Cerebral Hypoperfusion by Yata, Kenichiro, Nishimura, Yuhei, Unekawa, Miyuki, Tomita, Yutaka, Suzuki, Norihiro, Tanaka, Toshio, Mizoguchi, Akira, Tomimoto, Hidekazu

“…BACKGROUND AND PURPOSE—Proper brain function is maintained by an integrated system called the neurovascular unit (NVU) comprised cellular and acellular…”
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Protracted hypomobility in the absence of trigeminal sensitization after cortical spreading depolarization: Relevance to migraine postdrome by Shibata, Mamoru, Kitagawa, Satoshi, Tang, Chunghua, Unekawa, Miyuki, Kayama, Yohei, Shimizu, Toshihiko, Nakahara, Jin, Suzuki, Norihiro

“…Cortical spreading depolarization (CSD) can cause prolonged hypoactivity and photophobia postdrome symptoms, which leads to protracted disability in migraine…”
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RBC velocities in single capillaries of mouse and rat brains are the same, despite 10-fold difference in body size by Unekawa, Miyuki, Tomita, Minoru, Tomita, Yutaka, Toriumi, Haruki, Miyaki, Koichi, Suzuki, Norihiro

“…Abstract Employing high-speed camera laser-scanning confocal microscopy with RBC-tracking software, we previously showed that RBC velocities in…”
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Spatiotemporal dynamics of red blood cells in capillaries in layer I of the cerebral cortex and changes in arterial diameter during cortical spreading depression and response to hypercapnia in anesthetized mice by Unekawa, Miyuki, Tomita, Yutaka, Toriumi, Haruki, Osada, Takashi, Masamoto, Kazuto, Kawaguchi, Hiroshi, Izawa, Yoshikane, Itoh, Yoshiaki, Kanno, Iwao, Suzuki, Norihiro, Nakahara, Jin

“…Objective Control of red blood cell velocity in capillaries is essential to meet local neuronal metabolic requirements, although changes of capillary diameter…”
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Hyperperfusion Counteracted by Transient Rapid Vasoconstriction Followed by Long-Lasting Oligemia Induced by Cortical Spreading Depression in Anesthetized Mice by Unekawa, Miyuki, Tomita, Yutaka, Toriumi, Haruki, Osada, Takashi, Masamoto, Kazuto, Kawaguchi, Hiroshi, Itoh, Yoshiaki, Kanno, Iwao, Suzuki, Norihiro

“…Cortical spreading depression (CSD) involves mass depolarization of neurons and glial cells accompanied with changes in regional cerebral blood flow (rCBF) and…”
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Cellular Origin and Regulation of D-and L-Serine in in Vitro and in Vivo Models of Cerebral Ischemia by Abe, Takato, Suzuki, Masataka, Sasabe, Jumpei, Takahashi, Shinichi, Unekawa, Miyuki, Mashima, Kyoko, Iizumi, Takuya, Hamase, Kenji, Konno, Ryuichi, Aiso, Sadakazu, Suzuki, Norihiro

“…D-Serine is known to be essential for the activation of the N-methyl-D-aspartate (NMDA) receptor in the excitation of glutamatergic neurons, which have…”
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Suppressive effect of chronic peroral topiramate on potassium-induced cortical spreading depression in rats by Unekawa, Miyuki, Tomita, Yutaka, Toriumi, Haruki, Suzuki, Norihiro

“…To evaluate the chronic effect of topiramate (TPM) on cortical spreading depression (CSD), which is thought to be related to migraine aura. Male rats (n = 30)…”
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Potassium-induced cortical spreading depression bilaterally suppresses the electroencephalogram but only ipsilaterally affects red blood cell velocity in intraparenchymal capillaries by Unekawa, Miyuki, Tomita, Yutaka, Toriumi, Haruki, Masamoto, Kazuto, Kanno, Iwao, Suzuki, Norihiro

“…Cortical spreading depression (CSD) is a repetitive, propagating profile of mass depolarization of neuronal and glial cells, followed by sustained suppression…”
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