Search Results - "Undre, Nasrullah"

Quantitation of Tacrolimus in Human Whole Blood Samples Using the MITRA Microsampling Device by Undre, Nasrullah, Hussain, Imran, Meijer, John, Stanta, Johannes, Swan, Gordon, Dawson, Ian

“…The calcineurin inhibitor tacrolimus is a narrow therapeutic index medication, which requires therapeutic drug monitoring to optimize dose on the basis of…”
Get full text

Relative bioavailability of single doses of prolonged-release tacrolimus administered as a suspension, orally or via a nasogastric tube, compared with intact capsules: a phase 1 study in healthy participants by Undre, Nasrullah, Dickinson, James

“…ObjectiveTacrolimus, an immunosuppressant widely used in solid organ transplantation, is available as a prolonged-release capsule for once-daily oral…”
Get full text

Lower Variability in 24-Hour Exposure During Once-Daily Compared to Twice-Daily Tacrolimus Formulation in Kidney Transplantation by Stifft, Frank, Stolk, Leo M.L, Undre, Nasrullah, van Hooff, Johannes P, Christiaans, Maarten H.L

“…INTRODUCTIONTacrolimus has originally been registered as a twice-daily formulation (Prograf, Tac BID), although a once-daily formulation (Advagraf, Tac QD) is…”
Get full text

Validation of a Capillary Dry Blood Sample MITRA-Based Assay for the Quantitative Determination of Systemic Tacrolimus Concentrations in Transplant Recipients by Undre, Nasrullah, Dawson, Ian, Aluvihare, Varuna, Kamar, Nassim, Saliba, Faouzi, Torpey, Nicholas, Anaokar, Swapneel, Kazeem, Gbenga, Hussain, Imran

“…Tacrolimus is a narrow therapeutic index medication, which requires therapeutic drug monitoring to optimize dosing based on systemic exposure. MITRA…”
Get full text

γ-Cyclodextrin hydrogel for the sustained release of josamycin for potential ocular application by Huling, Jennifer, Oschatz, Stefan, Lange, Helge, Sterenczak, Katharina Anna, Stahnke, Thomas, Markhoff, Jana, Stachs, Oliver, Möller, Steffen, Undre, Nasrullah, Peil, Anita, Jünemann, Anselm, Grabow, Niels, Fuellen, Georg, Eickner, Thomas

“…Glaucoma is the leading cause of blindness worldwide. However, its surgical treatment, in particular via trabeculectomy, can be complicated by fibrosis. In…”
Get full text

Pharmacokinetics of Micafungin in Pediatric Patients With Invasive Candidiasis and Candidemia by Undre, Nasrullah A, Stevenson, Paul, Freire, Antonio, Arrieta, Antonio

“…Although micafungin pharmacokinetic values were comparable between younger (<5 years) and older children (≥5 years) with candidemia and invasive candidiasis,…”
Get full text

Pharmacokinetic profile of micafungin when co-administered with amphotericin B in healthy male subjects by UNDRE, Nasrullah A, STEVENSON, Paul, WILBRAHAM, Darren

“…Micafungin and amphotericin B are antifungal agents with potent activity against a broad spectrum of fungal spp., including Candida and Aspergillus. The…”
Get full text

A Novel, Dose-Adjusted Tacrolimus Trough-Concentration Model for Predicting and Estimating Variance After Kidney Transplantation by Kim, Janet, Wilson, Sam, Undre, Nasrullah A., Shi, Fei, Kristy, Rita M., Schwartz, Jason J.

“…Background and Objective Given that a high intrapatient variability (IPV) of tacrolimus whole blood concentration increases the risk for a poor kidney…”
Get full text

Pharmacokinetics of prolonged-release tacrolimus and implications for use in solid organ transplant recipients by Tanzi, Maria G., Undre, Nasrullah, Keirns, James, Fitzsimmons, William E., Brown, Malcolm, First, M. Roy

“…Prolonged‐release tacrolimus was developed as a once‐daily formulation with ethylcellulose as the excipient, resulting in slower release and reduction in peak…”
Get full text

Co-infections: testing macrolides for added benefit in patients with COVID-19 by Sterenczak, Katharina Anna, Barrantes, Israel, Stahnke, Thomas, Stachs, Oliver, Fuellen, Georg, Undre, Nasrullah

Get full text

Efficacy and safety of prolonged-release tacrolimus in stable pediatric allograft recipients converted from immediate-release tacrolimus - a Phase 2, open-label, single-arm, one-way crossover study by Rubik, Jacek, Debray, Dominique, Kelly, Deirdre, Iserin, Franck, Webb, Nicholas J A, Czubkowski, Piotr, Vondrak, Karel, Sellier-Leclerc, Anne-Laure, Rivet, Christine, Riva, Silvia, Tönshoff, Burkhard, D'Antiga, Lorenzo, Marks, Stephen D, Reding, Raymond, Kazeem, Gbenga, Undre, Nasrullah

“…There are limited clinical data regarding prolonged-release tacrolimus (PR-T) use in pediatric transplant recipients. This Phase 2 study assessed the efficacy…”
Get more information

Comparative pharmacokinetics of tacrolimus in de novo pediatric transplant recipients randomized to receive immediate‐ or prolonged‐release tacrolimus by Vondrak, Karel, Dhawan, Anil, Parisi, Francesco, Grenda, Ryszard, Debray, Dominique, Marks, Stephen D., Webb, Nicholas J. A., Lachaux, Alain, Kazeem, Gbenga, Undre, Nasrullah

“…Phase 2, parallel‐group, multicenter, open‐label, 4‐week study, comparing PK of PR‐T vs IR‐T in de novo pediatric patients undergoing primary kidney, liver, or…”
Get full text

Effect of Breakfast on the Exposure of the Once-Daily Tacrolimus Formulation in Stable Kidney Transplant Recipients by Stifft, Frank, Undre, Nasrullah, van Hooff, Johannes P, Christiaans, Maarten H L

“…The once-daily Tacrolimus formulation (Tac ONCE-DAILY) has to be taken on an empty stomach. This is inconvenient for patients and may hamper compliance. The…”
Get full text

Comparative pharmacokinetics of tacrolimus in stable pediatric allograft recipients converted from immediate‐release tacrolimus to prolonged‐release tacrolimus formulation by Rubik, Jacek, Debray, Dominique, Iserin, Franck, Vondrak, Karel, Sellier‐Leclerc, Anne‐Laure, Kelly, Deirdre, Czubkowski, Piotr, Webb, Nicholas J. A., Riva, Silvia, D'Antiga, Lorenzo, Marks, Stephen D., Rivet, Christine, Tönshoff, Burkhard, Kazeem, Gbenga, Undre, Nasrullah

“…This study was a Phase II, open‐label, multicenter, single‐arm, cross‐over study comparing the pharmacokinetics (PK) of tacrolimus in stable pediatric kidney,…”
Get full text

Pharmacokinetics of tacrolimus granules in pediatric de novo liver, kidney, and heart transplantation: The OPTION study by Webb, Nicholas J. A., Baumann, Ulrich, Camino, Manuela, Frauca, Esteban, Undre, Nasrullah, Garcia‐Guereta, Luis, Tönshoff, Burkhard, Reding, Raymond, Rubik, Jacek, Di‐Filippo, Sylvie, Deschenes, Georges

“…Tacrolimus granules were developed for patients who are unable to swallow capsules. Therapeutic drug monitoring (TDM) is required to optimize efficacy and…”
Get full text

Pharmacokinetics of tacrolimus‐based combination therapies by Undre, Nasrullah A

“…This paper reviews the pharmacokinetics of tacrolimus, with special reference to its combination with adjunctive immunosuppressants. Oral bioavailability of…”
Get full text

Optimizing Micafungin Dosing in Children by Undre, Nasrullah A, Stevenson, Paul, Freire, Antonio, Arrieta, Antonio

Get full text

Pharmacokinetics for once‐daily versus twice‐daily tacrolimus formulations in de novo liver transplantation: A randomized, open‐label trial by Fischer, Lutz, Trunečka, Pavel, Gridelli, Bruno, Roy, Andre, Vitale, Alessandro, Valdivieso, Andrés, Varo, Evaristo, Seehofer, Daniel, Lynch, Stephen, Samuel, Didier, Ericzon, Bo‐Goran, Boudjema, Karim, Karpf, Carmen, Undre, Nasrullah

“…Tacrolimus, a cornerstone immunosuppressant, is available as a twice‐daily formulation (tacrolimus bid). A once‐daily prolonged‐release formulation (tacrolimus…”
Get full text

Long-term Prolonged-release Tacrolimus-based Immunosuppression in De Novo Kidney Transplant Recipients: 5-Y Prospective Follow-up of Patients in the ADVANCE Study by Pernin, Vincent, Glyda, Maciej, Viklický, Ondrej, Lõhmus, Aleksander, Wennberg, Lars, Witzke, Oliver, von Zur-Mühlen, Bengt, Anaokar, Swapneel, Hurst, Martin, Kazeem, Gbenga, Undre, Nasrullah, Kuypers, Dirk R.J.

“…Although prolonged-release tacrolimus (PR-T) is widely approved for posttransplantation immunosuppression in kidney recipients, large-scale studies are…”
Get full text

Pharmacokinetics of 0.1% Tacrolimus Ointment After First and Repeated Application to Adults with Moderate to Severe Atopic Dermatitis by Rubins, Andris, Gutmane, Rita, Valdmane, Nora, Stevenson, Paul, Foster, Claire, Undre, Nasrullah

“…The systemic exposure to tacrolimus after first and repeated application of 0.1% tacrolimus ointment was investigated in 32 adults with moderate to severe…”
Get full text