Search Results - "Undheim, Eivind A. B"

Discovery of a selective NaV1.7 inhibitor from centipede venom with analgesic efficacy exceeding morphine in rodent pain models by Yang, Shilong, Xiao, Yao, Di Kang, Liu, Jie, Li, Yuan, Undheim, Eivind A. B., Klint, Julie K., Rong, Mingqiang, Lai, Ren, King, Glenn F.

“…Loss-of-function mutations in the human voltage-gated sodium channel Na V1.7 result in a congenital indifference to pain. Selective inhibitors of Na V1.7 are…”
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Phylogenetic analyses suggest centipede venom arsenals were repeatedly stocked by horizontal gene transfer by Undheim, Eivind A. B., Jenner, Ronald A.

“…Venoms have evolved over a hundred times in animals. Venom toxins are thought to evolve mostly by recruitment of endogenous proteins with physiological…”
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Ant venoms contain vertebrate-selective pain-causing sodium channel toxins by Robinson, Samuel D., Deuis, Jennifer R., Touchard, Axel, Keramidas, Angelo, Mueller, Alexander, Schroeder, Christina I., Barassé, Valentine, Walker, Andrew A., Brinkwirth, Nina, Jami, Sina, Bonnafé, Elsa, Treilhou, Michel, Undheim, Eivind A. B., Schmidt, Justin O., King, Glenn F., Vetter, Irina

“…Stings of certain ant species (Hymenoptera: Formicidae) can cause intense, long-lasting nociception. Here we show that the major contributors to these symptoms…”
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Production of recombinant disulfide-rich venom peptides for structural and functional analysis via expression in the periplasm of E. coli by Klint, Julie K, Senff, Sebastian, Saez, Natalie J, Seshadri, Radha, Lau, Ho Yee, Bende, Niraj S, Undheim, Eivind A B, Rash, Lachlan D, Mobli, Mehdi, King, Glenn F

“…Disulfide-rich peptides are the dominant component of most animal venoms. These peptides have received much attention as leads for the development of novel…”
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The venom and telopodal defence systems of the centipede Lithobius forficatus are functionally convergent serial homologues by Schendel, Vanessa, Müller, Carsten H G, Kenning, Matthes, Maxwell, Michael, Jenner, Ronald A, Undheim, Eivind A B, Sombke, Andy

“…Evolution of novelty is a central theme in evolutionary biology, yet studying the origins of traits with an apparently discontinuous origin remains a major…”
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A bivalent remipede toxin promotes calcium release via ryanodine receptor activation by Maxwell, Michael J., Thekkedam, Chris, Lamboley, Cedric, Chin, Yanni K.-Y., Crawford, Theo, Smith, Jennifer J., Liu, Junyu, Jia, Xinying, Vetter, Irina, Laver, Derek R., Launikonis, Bradley S., Dulhunty, Angela, Undheim, Eivind A. B., Mobli, Mehdi

“…Multivalent ligands of ion channels have proven to be both very rare and highly valuable in yielding unique insights into channel structure and pharmacology…”
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Melt With This Kiss: Paralyzing and Liquefying Venom of The Assassin Bug Pristhesancus plagipennis (Hemiptera: Reduviidae) by Walker, Andrew A., Madio, Bruno, Jin, Jiayi, Undheim, Eivind A.B., Fry, Bryan G., King, Glenn F.

“…Assassin bugs (Hemiptera: Heteroptera: Reduviidae) are venomous insects, most of which prey on invertebrates. Assassin bug venom has features in common with…”
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Intra-colony venom diversity contributes to maintaining eusociality in a cooperatively breeding ant by Robinson, Samuel D, Schendel, Vanessa, Schroeder, Christina I, Moen, Sarah, Mueller, Alexander, Walker, Andrew A, McKinnon, Naomi, Neely, G Gregory, Vetter, Irina, King, Glenn F, Undheim, Eivind A B

“…Eusociality is widely considered to evolve through kin selection, where the reproductive success of an individual's close relative is favored at the expense of…”
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Physiological constraints dictate toxin spatial heterogeneity in snake venom glands by Kazandjian, Taline D, Hamilton, Brett R, Robinson, Samuel D, Hall, Steven R, Bartlett, Keirah E, Rowley, Paul, Wilkinson, Mark C, Casewell, Nicholas R, Undheim, Eivind A. B

“…Venoms are ecological innovations that have evolved numerous times, on each occasion accompanied by the co-evolution of specialised morphological and…”
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Genomic, functional and structural analyses elucidate evolutionary innovation within the sea anemone 8 toxin family by Ashwood, Lauren M, Elnahriry, Khaled A, Stewart, Zachary K, Shafee, Thomas, Naseem, Muhammad Umair, Szanto, Tibor G, van der Burg, Chloé A, Smith, Hayden L, Surm, Joachim M, Undheim, Eivind A B, Madio, Bruno, Hamilton, Brett R, Guo, Shaodong, Wai, Dorothy C C, Coyne, Victoria L, Phillips, Matthew J, Dudley, Kevin J, Hurwood, David A, Panyi, Gyorgy, King, Glenn F, Pavasovic, Ana, Norton, Raymond S, Prentis, Peter J

“…The ShK toxin from Stichodactyla helianthus has established the therapeutic potential of sea anemone venom peptides, but many lineage-specific toxin families…”
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Functional and Proteomic Insights into Aculeata Venoms by Dashevsky, Daniel, Baumann, Kate, Undheim, Eivind A B, Nouwens, Amanda, Ikonomopoulou, Maria P, Schmidt, Justin O, Ge, Lilin, Kwok, Hang Fai, Rodriguez, Juanita, Fry, Bryan G

“…Aculeate hymenopterans use their venom for a variety of different purposes. The venom of solitary aculeates paralyze and preserve prey without killing it,…”
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On the venom system of centipedes (Chilopoda), a neglected group of venomous animals by Undheim, Eivind A.B., King, Glenn F.

“…Centipedes are among the oldest extant terrestrial arthropods and are an ecologically important group of soil and leaf litter predators. Despite their…”
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Selective spider toxins reveal a role for the Nav1.1 channel in mechanical pain by Osteen, Jeremiah D., Herzig, Volker, Gilchrist, John, Emrick, Joshua J., Zhang, Chuchu, Wang, Xidao, Castro, Joel, Garcia-Caraballo, Sonia, Grundy, Luke, Rychkov, Grigori Y., Weyer, Andy D., Dekan, Zoltan, Undheim, Eivind A. B., Alewood, Paul, Stucky, Cheryl L., Brierley, Stuart M., Basbaum, Allan I., Bosmans, Frank, King, Glenn F., Julius, David

“…Voltage-gated sodium (Na v ) channels initiate action potentials in most neurons, including primary afferent nerve fibres of the pain pathway. Local…”
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Molecular Phylogeny and Evolution of the Proteins Encoded by Coleoid (Cuttlefish, Octopus, and Squid) Posterior Venom Glands by Ruder, Tim, Sunagar, Kartik, Undheim, Eivind A. B., Ali, Syed A., Wai, Tak-Cheung, Low, Dolyce H. W., Jackson, Timothy N. W., King, Glenn F., Antunes, Agostinho, Fry, Bryan G.

“…In this study, we report for the first time a detailed evaluation of the phylogenetic history and molecular evolution of the major coleoid toxins: CAP,…”
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Structural venomics reveals evolution of a complex venom by duplication and diversification of an ancient peptide-encoding gene by Pineda, Sandy S., Chin, Yanni K.-Y., Undheim, Eivind A. B., Senff, Sebastian, Mobli, Mehdi, Dauly, Claire, Escoubas, Pierre, Nicholson, Graham M., Kaas, Quentin, Guo, Shaodong, Herzig, Volker, Mattick, John S., King, Glenn F.

“…Spiders are one of the most successful venomous animals, with more than 48,000 described species. Most spider venoms are dominated by cysteine-rich peptides…”
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Selective NaV1.1 activation rescues Dravet syndrome mice from seizures and premature death by Richards, Kay L., Milligan, Carol J., Richardson, Robert J., Jancovski, Nikola, Grunnet, Morten, Jacobson, Laura H., Undheim, Eivind A. B., Mobli, Mehdi, Chow, Chun Yuen, Herzig, Volker, Csoti, Agota, Panyi, Gyorgy, Reid, Christopher A., King, Glenn F., Petrou, Steven

“…Dravet syndrome is a catastrophic, pharmacoresistant epileptic encephalopathy. Disease onset occurs in the first year of life, followed by developmental delay…”
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Sea Anemone Toxins: A Structural Overview by Madio, Bruno, King, Glenn F, Undheim, Eivind A B

“…Sea anemones produce venoms of exceptional molecular diversity, with at least 17 different molecular scaffolds reported to date. These venom components have…”
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The assassin bug Pristhesancus plagipennis produces two distinct venoms in separate gland lumens by Walker, Andrew A., Mayhew, Mark L., Jin, Jiayi, Herzig, Volker, Undheim, Eivind A. B., Sombke, Andy, Fry, Bryan G., Meritt, David J., King, Glenn F.

“…The assassin bug venom system plays diverse roles in prey capture, defence and extra-oral digestion, but it is poorly characterised, partly due to its…”
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Mapping Enzyme Activity on Tissue by Functional Mass Spectrometry Imaging by Hamilton, Brett R., Marshall, David L., Casewell, Nicholas R., Harrison, Robert A., Blanksby, Stephen J., Undheim, Eivind A. B.

“…Enzymes are central components of most physiological processes, and are consequently implicated in various pathologies. High‐resolution maps of enzyme activity…”
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Deadly Proteomes: A Practical Guide to Proteotranscriptomics of Animal Venoms by Walker, Andrew A., Robinson, Samuel D., Hamilton, Brett F., Undheim, Eivind A. B., King, Glenn F.

“…Animal venoms are renowned for their toxicity, biochemical complexity, and as a source of compounds with potential applications in medicine, agriculture, and…”
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