Search Results - "Underwood, Timothy J."

The Oesophageal Cancer Multidisciplinary Team: Can Machine Learning Assist Decision-Making? by Thavanesan, Navamayooran, Vigneswaran, Ganesh, Bodala, Indu, Underwood, Timothy J.

“…Background The complexity of the upper gastrointestinal (UGI) multidisciplinary team (MDT) is continually growing, leading to rising clinician workload, time…”
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The AUGIS Survival Predictor: Prediction of Long-Term and Conditional Survival After Esophagectomy Using Random Survival Forests by Rahman, Saqib A, Walker, Robert C, Maynard, Nick, Trudgill, Nigel, Crosby, Tom, Cromwell, David A, Underwood, Timothy J

“…The aim of this study was to develop a predictive model for overall survival after esophagectomy using pre/postoperative clinical data and machine learning…”
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Targeting the Myofibroblastic Cancer-Associated Fibroblast Phenotype Through Inhibition of NOX4 by Hanley, Christopher J, Mellone, Massimiliano, Ford, Kirsty, Thirdborough, Steve M, Mellows, Toby, Frampton, Steven J, Smith, David M, Harden, Elena, Szyndralewiez, Cedric, Bullock, Marc, Noble, Fergus, Moutasim, Karwan A, King, Emma V, Vijayanand, Pandurangan, Mirnezami, Alex H, Underwood, Timothy J, Ottensmeier, Christian H, Thomas, Gareth J

“…Cancer-associated fibroblasts (CAFs) are tumor-promoting and correlate with poor survival in many cancers, which has led to their emergence as potential…”
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Cancer-associated fibroblasts predict poor outcome and promote periostin-dependent invasion in oesophageal adenocarcinoma by Underwood, Timothy J, Hayden, Annette L, Derouet, Mathieu, Garcia, Edwin, Noble, Fergus, White, Michael J, Thirdborough, Steve, Mead, Abbie, Clemons, Nicholas, Mellone, Massimiliano, Uzoho, Chudy, Primrose, John N, Blaydes, Jeremy P, Thomas, Gareth J

“…Interactions between cancer cells and cancer‐associated fibroblasts (CAFs) play an important role in tumour development and progression. In this study we…”
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Exosomal microRNAs derived from colorectal cancer-associated fibroblasts: role in driving cancer progression by Bhome, Rahul, Goh, Rebecca W, Bullock, Marc D, Pillar, Nir, Thirdborough, Stephen M, Mellone, Massimiliano, Mirnezami, Reza, Galea, Dieter, Veselkov, Kirill, Gu, Quan, Underwood, Timothy J, Primrose, John N, De Wever, Olivier, Shomron, Noam, Sayan, A Emre, Mirnezami, Alex H

“…Colorectal cancer is a global disease with increasing incidence. Mortality is largely attributed to metastatic spread and therefore, a mechanistic dissection…”
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Hiatal Hernia After Esophagectomy for Cancer by Brenkman, Hylke J.F., MD, Parry, Kevin, MD, Noble, Fergus, PhD, van Hillegersberg, Richard, MD, PhD, Sharland, Donna, Goense, Lucas, MD, Kelly, Jamie, BM, BSc (Hons), Byrne, James P., MD, Underwood, Timothy J., MD, PhD, Ruurda, Jelle P., MD, PhD

“…Background Hiatal hernia (HH) after esophagectomy is becoming more relevant due to improvements in survival. This study evaluated and compared the occurrence…”
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Risk Assessment Using a Novel Score to Predict Anastomotic Leak and Major Complications after Oesophageal Resection by Noble, Fergus, Curtis, Nathan, Harris, Scott, Kelly, Jamie J., Bailey, Ian S., Byrne, James P., Underwood, Timothy J.

“…Background Oesophagectomy is associated with significant morbidity and mortality. A simple score to define a patient's risk of developing major complications…”
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Chronic gastric ulceration: a novel manifestation of IgG4-related disease? by Bateman, Adrian C, Sommerlad, Matthew, Underwood, Timothy J

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The relevance of the Siewert classification in the era of multimodal therapy for adenocarcinoma of the gastro-oesophageal junction by Curtis, Nathan J., Noble, Fergus, Bailey, Ian S., Kelly, Jamie J., Byrne, James P., Underwood, Timothy J.

“…Introduction The Siewert classification has been used to plan treatment for tumours of the gastro‐oesophageal junction since its proposal in the 1980s. The…”
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Pharmacological EZH2 inhibition combined with retinoic acid treatment promotes differentiation and apoptosis in rhabdomyosarcoma cells by O'Brien, Eleanor, Tse, Carmen, Tracy, Ian, Reddin, Ian, Selfe, Joanna, Gibson, Jane, Tapper, William, Pengelly, Reuben J, Gao, Jinhui, Aladowicz, Ewa, Petts, Gemma, Thway, Khin, Popov, Sergey, Kelsey, Anna, Underwood, Timothy J, Shipley, Janet, Walters, Zoë S

“…Abstract Background Rhabdomyosarcomas (RMS) are predominantly paediatric sarcomas thought to originate from muscle precursor cells due to impaired myogenic…”
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Fibroblasts derived from oesophageal adenocarcinoma differ in DNA methylation profile from normal oesophageal fibroblasts by Smith, Eric, Palethorpe, Helen M., Hayden, Annette L., Young, Joanne P., Underwood, Timothy J., Drew, Paul A.

“…Oesophageal adenocarcinoma (OAC) is increasing in incidence and has a poor prognosis. Tumour derived fibroblasts (TDFs) differ functionally from normal…”
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Cardiopulmonary exercise variables and their association with postoperative morbidity and mortality after major oesophagogastric cancer surgery—a multicentre observational study by West, Malcolm A., Rahman, Saqib, Jack, Sandy, Grocott, Michael P.W., Levett, Denny Z.H., Rashid, Yasir, Griffiths, John, Ezra, Martin, Ayres, Lyndsay, Neville-Webbe, Helen, Javed, Muhammad Shafiq, Shrotri, Milind, Khan, Iftikhar, Whitmore, David, Prabhu, Pradeep, Timbrell, David, Allen, Sophie, Packham, Andrew O., Sharpe, David, Anderson, Helen, Minto, Gary, McAleer, Samuel, McPhail, Stuart, Alasmar, Mohamed, Hartley, Robert A., Sultan, Javed, Grace, Ben, Underwood, Timothy J., Byrne, James, Noble, Fergus, Kelly, Jamie, Ansell, Gillian, Edwards, Mark

“…Outcomes after oesophagogastric cancer surgery remain poor. Cardiopulmonary exercise testing (CPET) used for risk stratification before oesophagogastric cancer…”
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The role of systemic inflammatory and nutritional blood-borne markers in predicting response to neoadjuvant chemotherapy and survival in oesophagogastric cancer by Noble, Fergus, Hopkins, James, Curtis, Nathan, Kelly, Jamie J., Bailey, Ian S., Byrne, James P., Bateman, Adrian C., Bateman, Andrew R., Underwood, Timothy J.

“…The aim of this study was to interrogate whether blood-borne inflammatory and nutritional markers predict long-term survival and response to neoadjuvant…”
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Author response to: Impact of postoperative chemotherapy on survival for oesophagogastric adenocarcinoma after preoperative chemotherapy and surgery by Rahman, Saqib A, Underwood, Timothy J

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High proportion of PD-1 and CD39 positive CD8+ tissue resident T lymphocytes correlates with better clinical outcome in resected human oesophageal adenocarcinoma by Hill, Samuel L., Sugiyarto, Gessa, Harrington, Jack, James, Edward, Underwood, Timothy J., Elliott, Tim

“…Objective To understand the CD8+ tumour infiltrating lymphocyte (TIL) compartment of oesophageal adenocarcinoma (OAC) with regards to markers of lymphocyte…”
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Machine learning to predict curative multidisciplinary team treatment decisions in oesophageal cancer by Thavanesan, Navamayooran, Bodala, Indu, Walters, Zoë, Ramchurn, Sarvapali, Underwood, Timothy J, Vigneswaran, Ganesh

“…Rising workflow pressures within the oesophageal cancer (OC) multidisciplinary team (MDT) can lead to variability in decision-making, and health inequality…”
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Review: Targeting EZH2 in neuroblastoma by Gao, Jinhui, Fosbrook, Claire, Gibson, Jane, Underwood, Timothy J., Gray, Juliet C., Walters, Zoë S.

“…•Enhancer of Zeste Homolog 2 (EZH2) is overexpressed in neuroblastoma.•EZH2 is a histone methyltransferase that represses gene transcription.•EZH2 regulates…”
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The genetic profile and molecular subtypes of human pseudomyxoma peritonei and appendiceal mucinous neoplasms: a systematic review by Murage, Nora Wangari, Ahmed, Nada Mabrouk, Underwood, Timothy J., Walters, Zoë S., Breininger, Stella Panagio

“…Pseudomyxoma peritonei (PMP) is a rare, progressive, slowly growing neoplastic condition which is poorly understood, with a 5-year progression-free survival…”
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Prevalence and Risk Factors for Malignant Nodal Involvement in Early esophago-gastric Adenocarcinoma: Results from the Multicenter Retrospective Congress Study (endosCopic resectiON, esophaGectomy or Gastrectomy For Early Esophagogastric Cancers) by Pucher, Philip H, Rahman, Saqib A, Bhandari, Pradeep, Blencowe, Natalie, Chidambaram, Swathikan, Crosby, Tom, Evans, Richard Pt, Griffiths, Ewen A, Kamarajah, Sivesh K, Markar, Sheraz R, Trudgill, Nigel, Underwood, Timothy J, Gossage, James A

“…The aim of this study was to quantify LNM risk and outcomes following treatment of early esophago-gastric (EG) adenocarcinoma. The standard of care for early…”
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Insights from explainable AI in oesophageal cancer team decisions by Thavanesan, Navamayooran, Farahi, Arya, Parfitt, Charlotte, Belkhatir, Zehor, Azim, Tayyaba, Vallejos, Elvira Perez, Walters, Zoë, Ramchurn, Sarvapali, Underwood, Timothy J., Vigneswaran, Ganesh

“…Clinician-led quality control into oncological decision-making is crucial for optimising patient care. Explainable artificial intelligence (XAI) techniques…”
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