Search Results - "Underwood, Tim J"

A subset of myofibroblastic cancer-associated fibroblasts regulate collagen fiber elongation, which is prognostic in multiple cancers by Hanley, Christopher J, Noble, Fergus, Ward, Matthew, Bullock, Marc, Drifka, Cole, Mellone, Massimiliano, Manousopoulou, Antigoni, Johnston, Harvey E, Hayden, Annette, Thirdborough, Steve, Liu, Yuming, Smith, David M, Mellows, Toby, Kao, W John, Garbis, Spiros D, Mirnezami, Alex, Underwood, Tim J, Eliceiri, Kevin W, Thomas, Gareth J

“…Collagen structure has been shown to influence tumor cell invasion, metastasis and clinical outcome in breast cancer. However, it remains unclear how it…”
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Comparison of optimized methodologies for isolating nuclei from esophageal tissue by Kimbley, Lucy M, Parker, Rachel, Harrington, Jack, Walker, Robert C, Grace, Ben, West, Jonathan J, Underwood, Tim J, Rose-Zerilli, Matthew Jj

“…Single-nuclei RNA sequencing allows single cell-based analysis in frozen tissue, ameliorating cell recovery biases associated with enzymatic dissociation…”
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Total neoadjuvant therapy in oesophageal and gastro-oesophageal junctional adenocarcinoma by Clements, Hollie A., Underwood, Tim J., Petty, Russell D.

“…Adenocarcinoma of the oesophagus and gastro-oesophageal junction represent a large burden of cancer death in the Western World with an increasing incidence. In…”
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Impact of postoperative chemotherapy on survival for oesophagogastric adenocarcinoma after preoperative chemotherapy and surgery by Rahman, Saqib, Thomas, Betsan, Maynard, Nick, Park, Min Hae, Wahedally, Muhammad, Trudgill, Nigel, Crosby, Tom, Cromwell, David A, Underwood, Tim J

“…Perioperative chemotherapy is widely used in the treatment of oesophagogastric adenocarcinoma (OGAC) with a substantial survival benefit over surgery alone…”
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Identification of neoantigens in oesophageal adenocarcinoma by Nicholas, Ben, Bailey, Alistair, McCann, Katy J., Wood, Oliver, Walker, Robert C., Parker, Robert, Ternette, Nicola, Elliott, Tim, Underwood, Tim J., Johnson, Peter, Skipp, Paul

“…Oesophageal adenocarcinoma (OAC) has a relatively poor long‐term survival and limited treatment options. Promising targets for immunotherapy are short peptide…”
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Multicenter, Prospective Cohort Study of Oesophageal Injuries and Related Clinical Outcomes (MUSOIC study) by Owen, Richard P., Chidambaram, Swathikan, Griffiths, Ewen A, Sultan, Javed, Phillips, Alexander W, Vohra, Ravindra, Preston, Shaun, Gossage, James, Hanna, George B., Underwood, Tim J., Maynard, Nick, Markar, Sheraz R.

“…To identify prognostic factors associated with 90-day mortality in patients with oesophageal perforation (OP), and characterize the specific timeline from…”
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Pathologic Lymph Node Regression After Neoadjuvant Chemotherapy Predicts Recurrence and Survival in Esophageal Adenocarcinoma: A Multicenter Study in the United Kingdom by Moore, Jonathan L, Green, Michael, Santaolalla, Aida, Deere, Harriet, Evans, Richard P T, Elshafie, Mona, Lavery, Anita, McManus, Damian T, McGuigan, Andrew, Douglas, Rosalie, Horne, Joanne, Walker, Robert, Mir, Hira, Terlizzo, Monica, Kamarajah, Sivesh K, Van Hemelrijck, Mieke, Maisey, Nick, Sita-Lumsden, Ailsa, Ngan, Sarah, Kelly, Mark, Baker, Cara R, Kumar, Sacheen, Lagergren, Jesper, Allum, William H, Gossage, James A, Griffiths, Ewen A, Grabsch, Heike I, Turkington, Richard C, Underwood, Tim J, Smyth, Elizabeth C, Fitzgerald, Rebecca C, Cunningham, David, Davies, Andrew R

“…There is limited evidence regarding the prognostic effects of pathologic lymph node (LN) regression after neoadjuvant chemotherapy for esophageal…”
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Nasogastric tube drainage and pyloric intervention after oesophageal resection: UK practice variation and effect on outcomes by Bull, Alexander, Pucher, Philip H., Maynard, Nick, Underwood, Tim J., Lagergren, Jesper, Gossage, James A.

“…Over 1500 patients with oesophageal cancer undergo a resection in the UK each year. At surgery, patients commonly have a nasogastric tube (NGT) placed and may…”
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Whole Genome Methylation Analysis of Nondysplastic Barrett Esophagus that Progresses to Invasive Cancer by Dilworth, Mark P, Nieto, Tom, Stockton, Jo D, Whalley, Celina M, Tee, Louise, James, Jonathan D, Noble, Fergus, Underwood, Tim J, Hallissey, Michael T, Hejmadi, Rahul, Trudgill, Nigel, Tucker, Olga, Beggs, Andrew D

“…OBJECTIVE:To investigate differences in methylation between patients with nondysplastic Barrett esophagus who progress to invasive adenocarcinoma and those who…”
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A modified Delphi process to establish future research priorities in malignant oesophagogastric surgery by Wilson, Michael SJ, Blencowe, Natalie S., Boyle, Christopher, Knight, Stephen R., Petty, Russell, Vohra, Ravi S., Underwood, Tim J.

“…With rapid advancement in the genomics of oesophagogastric (OG) cancer and raised expectations in clinical outcomes from patients and clinicians alike there is…”
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Refining pathological evaluation of neoadjuvant therapy for adenocarcinoma of the esophagus by Noble, Fergus, Nolan, Luke, Bateman, Adrian C, Byrne, James P, Kelly, Jamie J, Bailey, Ian S, Sharland, Donna M, Rees, Charlotte N, Iveson, Timothy J, Underwood, Tim J, Bateman, Andrew R

“…To assess tumour regression grade (TRG) and lymph node downstaging to help define patients who benefit from neoadjuvant chemotherapy. Two hundred and eighteen…”
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Genomic Analysis of Response to Neoadjuvant Chemotherapy in Esophageal Adenocarcinoma by Izadi, Fereshteh, Sharpe, Benjamin P, Breininger, Stella P, Secrier, Maria, Gibson, Jane, Walker, Robert C, Rahman, Saqib, Devonshire, Ginny, Lloyd, Megan A, Walters, Zoë S, Fitzgerald, Rebecca C, Rose-Zerilli, Matthew J J, Underwood, Tim J, On Behalf Of Occams

“…Neoadjuvant therapy followed by surgery is the standard of care for locally advanced esophageal adenocarcinoma (EAC). Unfortunately, response to neoadjuvant…”
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Androgen Receptor and Androgen-Responsive Gene FKBP5 Are Independent Prognostic Indicators for Esophageal Adenocarcinoma by Smith, Eric, Palethorpe, Helen M., Ruszkiewicz, Andrew R., Edwards, Suzanne, Leach, Damien A., Underwood, Tim J., Need, Eleanor F., Drew, Paul A.

“…Background Esophageal adenocarcinoma is a male-dominant disease, but the role of androgens is unclear. Aims To examine the expression and clinical correlates…”
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Sex-related differences in oncologic outcomes, operative complications and health-related quality of life after curative-intent oesophageal cancer treatment: multicentre retrospective analysis by Mantziari, Styliani, Elliott, Jessie A, Markar, Sheraz R, Klevebro, Fredrik, Goense, Lucas, Johar, Asif, Lagergren, Pernilla, Zaninotto, Giovanni, van Hillegersberg, Richard, van Berge Henegouwen, Mark I, Schäfer, Markus, Nilsson, Magnus, Hanna, George B, Reynolds, John V

“…Abstract Background Oesophageal cancer, in particular adenocarcinoma, has a strong male predominance. However, the impact of patient sex on operative and…”
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An International Multicenter Study Exploring Whether Surveillance After Esophageal Cancer Surgery Impacts Oncological and Quality of Life Outcomes (ENSURE) by Elliott, Jessie A., Markar, Sheraz R., Klevebro, Fredrik, Johar, Asif, Goense, Lucas, Lagergren, Pernilla, Zaninotto, Giovanni, van Hillegersberg, Richard, Henegouwen, Mark I. van Berge, Nilsson, Magnus, Hanna, George B., Reynolds, John V.

“…To determine the impact of surveillance on recurrence pattern, treatment, survival and health-related quality-of-life (HRQL) following curative-intent…”
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Androgen Receptor and Androgen-Responsive Gene FKBP5 Are Independent Prognostic Indicators for Esophageal Adenocarcinoma by Smith, Eric, Palethorpe, Helen M., Ruszkiewicz, Andrew R., Edwards, Suzanne, Leach, Damien A., Underwood, Tim J., Need, Eleanor F., Drew, Paul A.

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