Search Results - "Underwood, Lowell J"

Ovarian tumor cells express a transmembrane serine protease: a potential candidate for early diagnosis and therapeutic intervention by Tanimoto, H, Underwood, L J, Wang, Y, Shigemasa, K, Parmley, T H, O'Brien, T J

“…Proteases have been implicated in the extracellular modulation required for tumor growth and invasion. In an effort to categorize those proteases contributing…”
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The CA 125 gene: an extracellular superstructure dominated by repeat sequences by O'Brien, T J, Beard, J B, Underwood, L J, Dennis, R A, Santin, A D, York, L

“…CA 125 has long presented problems to both clinicians and investigators because there was no definitive information on its structure and function. Here, we…”
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The CA 125 gene: a newly discovered extension of the glycosylated N-terminal domain doubles the size of this extracellular superstructure by O'Brien, Timothy J, Beard, John B, Underwood, Lowell J, Shigemasa, Kazushi

“…CA 125 is a well-established marker for patients diagnosed with ovarian carcinoma. It is clearly elaborated in serous cystadenocarcinomas and less likely to be…”
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Cloning of tumor-associated differentially expressed gene-14, a novel serine protease overexpressed by ovarian carcinoma by UNDERWOOD, L. J, TANIMOTO, H, YINXIANG WANG, SHIGEMASA, K, PARMLEY, T. H, O'BRIEN, T. J

“…The family of enzymes known as serine proteases supports many biological functions for cancer cells, including activation of growth and angiogenic factors and…”
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Human kallikrein 8 (hK8/TADG-14) expression is associated with an early clinical stage and favorable prognosis in ovarian cancer by Shigemasa, Kazushi, Tian, Xiurong, Gu, Lijun, Tanimoto, Hirotoshi, Underwood, Lowell J, O'Brien, Timothy J, Ohama, Koso

“…The purpose of this study was to examine human kallikrein 8 (hK8/TADG-14) expression in epithelial ovarian tumors and to investigate the association of hK8…”
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Increased expression of protease M in ovarian tumors by Tanimoto, H, Underwood, L J, Shigemasa, K, Parmley, T H, O'Brien, T J

“…Proteases are known to play important roles in tumor invasion and metastasis. Protease M, which was originally identified by Anisowicz and colleagues in 1996,…”
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The matrix metalloprotease pump-1 (MMP-7, Matrilysin): A candidate marker/target for ovarian cancer detection and treatment by Tanimoto, H, Underwood, L J, Shigemasa, K, Parmley, T H, Wang, Y, Yan, Y, Clarke, J, O'Brien, T J

“…Matrix metalloproteases are known to play an important role in tumor invasion by mediating degradation of extracellular matrix. In this study, we have…”
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The stratum corneum chymotryptic enzyme that mediates shedding and desquamation of skin cells is highly overexpressed in ovarian tumor cells by Tanimoto, Hirotoshi, Underwood, Lowell J., Shigemasa, Kazushi, Yan M.S., Yan, Clarke, John, Parmley, Tim H., O'Brien, Timothy J.

“…BACKGROUND Proteases play essential roles in the process of tumor invasion and metastasis. The serine protease stratum corneum chymotryptic enzyme (SCCE) has…”
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Overexpression of testisin, a serine protease expressed by testicular germ cells, in epithelial ovarian tumor cells by Shigemasa, K, Underwood, L J, Beard, J, Tanimoto, H, Ohama, K, Parmley, T H, O'Brien, T J

“…In a continued effort to identify and characterize secreted proteases that are overexpressed in ovarian carcinomas, we discovered the testisin protease as such…”
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Ovarian tumor cells express a novel multi-domain cell surface serine protease by Underwood, Lowell J., Shigemasa, Kazushi, Tanimoto, Hirotoshi, Beard, John B., Schneider, Elizabeth Nestrud, Wang, Yinxiang, Parmley, Tim H., O’Brien, Timothy J.

“…Serine proteases serve many functions in normal biological processes. These functions are often usurped by cancer cells to allow progression of tumors by…”
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Expression of HOXD10 gene in normal endometrium and endometrial adenocarcinoma by Osborne, J, Hu, C, Hawley, C, Underwood, L J, O'Brien, T J, Baker, V V

“…Hox genes encode DNA transcription regulatory proteins that contain a conserved 61 amino acid protein called the homeodomain. Although best known for their…”
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