Search Results - "Underwood, Christina R"

Total synthesis and structure–activity relationship studies of a series of selective G protein inhibitors by Xiong, Xiao-Feng, Zhang, Hang, Underwood, Christina R., Harpsøe, Kasper, Gardella, Thomas J., Wöldike, Mie F., Mannstadt, Michael, Gloriam, David E., Bräuner-Osborne, Hans, Strømgaard, Kristian

“…G proteins are key mediators of G protein-coupled receptor signalling, which facilitates a plethora of important physiological processes. The cyclic…”
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Structure–Activity Relationship Studies of the Natural Product Gq/11 Protein Inhibitor YM‐254890 by Xiong, Xiao‐Feng, Zhang, Hang, Boesgaard, Michael W., Underwood, Christina R., Bräuner‐Osborne, Hans, Strømgaard, Kristian

“…G proteins act as molecular switches in G protein‐coupled receptor signaling pathways and are key mediators for numerous important physiological processes. The…”
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Structure–activity relationship and conformational studies of the natural product cyclic depsipeptides YM-254890 and FR900359 by Zhang, Hang, Nielsen, Alexander L., Boesgaard, Michael W., Harpsøe, Kasper, Daly, Norelle L., Xiong, Xiao-Feng, Underwood, Christina R., Haugaard-Kedström, Linda M., Bräuner-Osborne, Hans, Gloriam, David E., Strømgaard, Kristian

“…G proteins are key mediators in the signaling of G protein-coupled receptors and involved in a plethora of important physiological processes. The natural…”
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Overlapping binding site for the endogenous agonist, small-molecule agonists, and ago-allosteric modulators on the ghrelin receptor by Holst, Birgitte, Frimurer, Thomas M, Mokrosinski, Jacek, Halkjaer, Tine, Cullberg, Karina B, Underwood, Christina R, Schwartz, Thue W

“…A library of robust ghrelin receptor mutants with single substitutions at 22 positions in the main ligand-binding pocket was employed to map binding sites for…”
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In vitro cell cultures of Brunner's glands from male mouse to study GLP-1 receptor function by Voetmann, Louise M, Underwood, Christina R, Rolin, Bidda, Hansen, Axel K, Kirk, Rikke K, Pyke, Charles, Knudsen, Lotte B, Frederiksen, Klaus S

“…Exocrine glands in the submucosa of the proximal duodenum secrete alkaline fluid containing mucus to protect the intestinal mucosa from acidic stomach…”
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Delineation of molecular determinants for FR900359 inhibition of Gq/11 unlocks inhibition of Gαs by Boesgaard, Michael W., Harpsøe, Kasper, Malmberg, Michelle, Underwood, Christina R., Inoue, Asuka, Mathiesen, Jesper M., König, Gabriele M., Kostenis, Evi, Gloriam, David E., Bräuner-Osborne, Hans

“…Heterotrimeric G proteins are essential mediators of intracellular signaling of G protein–coupled receptors. The Gq/11 subfamily consists of Gq, G11, G14, and…”
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Structure–Activity Relationship Studies of the Cyclic Depsipeptide Natural Product YM‐254890, Targeting the Gq Protein by Zhang, Hang, Xiong, Xiao‐Feng, Boesgaard, Michael W., Underwood, Christina R., Bräuner‐Osborne, Hans, Strømgaard, Kristian

“…Extracellular signals perceived by G protein‐coupled receptors are transmitted via G proteins, and subsequent intracellular signaling cascades result in a…”
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Structure-Activity Relationship Studies of the Natural Product G q/11 Protein Inhibitor YM-254890 by Xiong, Xiao-Feng, Zhang, Hang, Boesgaard, Michael W, Underwood, Christina R, Bräuner-Osborne, Hans, Strømgaard, Kristian

“…G proteins act as molecular switches in G protein-coupled receptor signaling pathways and are key mediators for numerous important physiological processes. The…”
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Structure-Activity Relationship Studies of the Cyclic Depsipeptide Natural Product YM-254890, Targeting the G q Protein by Zhang, Hang, Xiong, Xiao-Feng, Boesgaard, Michael W, Underwood, Christina R, Bräuner-Osborne, Hans, Strømgaard, Kristian

“…Extracellular signals perceived by G protein-coupled receptors are transmitted via G proteins, and subsequent intracellular signaling cascades result in a…”
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Cover Picture: Structure–Activity Relationship Studies of the Cyclic Depsipeptide Natural Product YM‐254890, Targeting the Gq Protein (ChemMedChem 11/2017) by Zhang, Hang, Xiong, Xiao‐Feng, Boesgaard, Michael W., Underwood, Christina R., Bräuner‐Osborne, Hans, Strømgaard, Kristian

“…The front cover picture shows the X‐ray crystal structure of the natural product, cyclic depsipeptide YM‐254890 bound to the Gαi/q protein (PDB: 3AH8)…”
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Cover Picture: Structure–Activity Relationship Studies of the Cyclic Depsipeptide Natural Product YM‐254890, Targeting the G q Protein (ChemMedChem 11/2017) by Zhang, Hang, Xiong, Xiao‐Feng, Boesgaard, Michael W., Underwood, Christina R., Bräuner‐Osborne, Hans, Strømgaard, Kristian

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Abstract LB-135: Selective small molecule inhibition of the N-terminal BET bromodomain by Seitzberg, Jimmi G., Hansen, Margit H., Kronborg, Tine T. Akinleminu, Underwood, Christina R., Friberg, Gitte, Tonnesen, Berit, Teuber, Lene, Franch, Thomas, Nielsen, Søren J.

“…Introduction: The bromodomain acetyl-lysine ‘readers’ is an emerging target class with particular interest centered around the BET family proteins BRD2, 3, and…”
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Delineation of molecular determinants for FR900359 inhibition of G q/11 unlocks inhibition of Gα s by Boesgaard, Michael W, Harpsøe, Kasper, Malmberg, Michelle, Underwood, Christina R, Inoue, Asuka, Mathiesen, Jesper M, König, Gabriele M, Kostenis, Evi, Gloriam, David E, Bräuner-Osborne, Hans

“…Heterotrimeric G proteins are essential mediators of intracellular signaling of G protein-coupled receptors. The G subfamily consists of G , G , G , and G…”
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