Search Results - "Underwood, Adam C."
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Transcriptional analysis of the multiple Sry genes and developmental program at the onset of testis differentiation in the rat
Published in Biology of sex differences (12-05-2020)“…The commonly used laboratory rat, Rattus norvegicus, is unique in having multiple Sry gene copies found on the Y chromosome, with different copies encoding…”
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Analysis of Sry duplications on the Rattus norvegicus Y-chromosome
Published in BMC genomics (14-11-2013)“…Gene copy number variation plays a large role in the evolution of genomes. In Rattus norvegicus and other rodent species, the Y-chromosome has accumulated…”
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The synthesis and toxicity of tripodal tricarbonyl rhenium complexes as radiopharmaceutical models
Published in Journal of inorganic biochemistry (01-06-2010)“…We report the synthesis and toxicity of a series of rhenium(I) tricarbonyl complexes incorporating the trisaminomethylethane (TAME) ligand. Compounds with the…”
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From Rat to Human: Regulation of Renin-Angiotensin System Genes by Sry
Published in International Journal of Hypertension (01-01-2012)“…The testis determining protein, Sry, has functions outside of testis determination. Multiple Sry loci are found on the Y-chromosome. Proteins from these loci…”
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Regulation of multiple renin–angiotensin system genes by Sry
Published in Journal of hypertension (01-01-2010)“…BACKGROUND AND OBJECTIVEWe demonstrated that the Sry gene complex on the spontaneously hypertensive rat (SHR) Y chromosome is a candidate locus for…”
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The phenotypic impact of the male-specific region of chromosome-Y in inbred mating: the role of genetic variants and gene duplications in multiple inbred rat strains
Published in Biology of sex differences (03-02-2016)“…The male-specific region of chromosome-Y (MSY) contributes to phenotypes outside of testis development and has a high rate of evolution between mammalian…”
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SOX18 Variant E137K Reduces Transcriptional Activity of SOX Responsive Promoters in Cotransfected Epithelia
Published in The FASEB journal (01-04-2019)“…SOX (SRY‐related box) proteins are important regulators of cellular differentiation during both embryonic development and throughout life affecting overall…”
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Defining Functional Human Variants in the HMG Box of SOX Genes of >60,000 Human Individuals for Potential Cardiovascular and Cancer Genetic Risk
Published in The FASEB journal (01-04-2018)“…Our group and others have previously linked SOX (SRY‐related HMG‐box) genes to cardiovascular regulation and cancer. SOX proteins are transcription factors…”
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Differential intracellular localization of Sry proteins expressed in Rattus norvegicus
Published in The FASEB journal (01-04-2009)“…Abstract only Sry is a transcription factor with a conserved HMG domain that facilitates DNA interactions and nuclear localization, through amino (n) and…”
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