Search Results - "Underberg, W.J.M."

Derivatization in capillary electrophoresis by Bardelmeijer, H.A., Lingeman, H., de Ruiter, C., Underberg, W.J.M.

“…In recent years capillary electrophoresis (CE) has been developed into a versatile separation technique, next to gas and liquid chromatography (LC), well…”
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Capillary electrophoresis as a versatile tool for the bioanalysis of drugs—a review by Boone, C.M, Waterval, J.C.M, Lingeman, H, Ensing, K, Underberg, W.J.M

“…This review article presents an overview of current research on the use of capillary electrophoretic techniques for the analysis of drugs in biological…”
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High-performance liquid chromatographic analysis of the new antitumour drug SK&F 104864-A (NSC 609699) in plasma by Beijnen, J H, Smith, B R, Keijer, W J, van Gijn, R, ten Bokkel Huinink, W W, Vlasveld, L T, Rodenhuis, S, Underberg, W J

“…A high-performance liquid chromatographic (HPLC) assay is described for the determination of the new, investigational antitumour drug SK&F 104864-A and its…”
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Systematic interpretation of pH-degradation profiles. A critical review by van der Houwen, O.A.G.J., de Loos, M.R., Beijnen, J.H., Bult, A., Underberg, W.J.M.

“…In this study we discuss the application of the general models for pH degradation profiles for specific acid, solvent and base catalysis, both in the absence…”
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HPLC determination of doxorubicin, doxorubicinol and four aglycone metabolites in plasma of AIDS patients by Beijnen, J H, Meenhorst, P L, van Gijn, R, Fromme, M, Rosing, H, Underberg, W J

“…A high-performance liquid chromatographic (HPLC) assay has been developed for the determination of the anticancer drug doxorubicin and the metabolites…”
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Aspects of the chemical stability of mitomycin and porfiromycin in acidic solution by Underberg, W J, Lingeman, H

“…Aspects of the degradations of mitomycin and porfiromycin were studied. The initial degradation processes of the compounds in an acidic medium were…”
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Oxidative degradation of pharmaceutically important phenothiazines III: Kinetics and mechanism of promethazine oxidation by Underberg, W J

“…The kinetics of the thermal degradation of promethazine in an acidic medium under various conditions were investigated. The degradation of promethazine and the…”
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Oxidative degradation pharmaceutically important phenothiazines II: Quantitative determination of promethazine and some degradation products by Underberg, W J

“…Methods for the determination of promethazine and several degradation products, which can be used in kinetic studies, were developed. All determinations were…”
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Degradation kinetics of methacrylated dextrans in aqueous solution by van Dijk-Wolthuis, W N, van Steenbergen, M J, Underberg, W J, Hennink, W E

“…The kinetics of the hydrolysis of glycidyl methacrylate derivatized dextran (dex-MA), hydroxyethyl methacrylate derivatized dextran (dex-Hema, and hydroxyethyl…”
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Liposomes as carriers of the antiretroviral agent dideoxycytidine-5′-triphosphate by Oussoren, C, Magnani, M, Fraternale, A, Casabianca, A, Chiarantini, L, Ingebrigsten, R, Underberg, W.J.M, Storm, G

“…The presence and replication of the human immunodeficiency virus (HIV) in cells of the mononuclear phagocyte system (MPS) together with the preferential uptake…”
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Chemical hydrolysis of DOTAP and DOPE in a liposomal environment by Vernooij, E.A.A.M, Kettenes-van den Bosch, J.J, Underberg, W.J.M, Crommelin, D.J.A

“…In this study the hydrolysis kinetics of 1,2-dipalmitoyl- sn-glycero-3-phosphocholine (DPPC), 1,2-dioleoyl- sn-glycero-3-phosphoethanolamine (DOPE) and…”
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Separation and detection techniques for peptides and proteins in stability research and bioanalysis by Underberg, W.J.M, Hoitink, M.A, Reubsaet, J.L.E, Waterval, J.C.M

“…In this paper, a brief overview of the most commonly used methods for the separation and analysis of peptides and proteins in stability and bioanalysis studies…”
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Degradation study of the investigational anticancer drug clanfenur by Sluiter, C., Kettenes-van den Bosch, J.J., Hop, E., van der Houwen, O.A.G.J., Underberg, W.J.M., Bult, A.

“…Clanfenur belongs to a new group of substituted benzoylphenylureas. The drug shows both in vitro and in vivo antitumour activity. To assess its chemical…”
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Equilibrium kinetics of the new experimental anti-tumour compound SK&F 104864-A in aqueous solution by Underberg, W J, Goossen, R M, Smith, B R, Beijnen, J H

“…The equilibrium kinetics of lactone ring hydrolysis in the new experimental anti-tumour compound SK&F 104864-A. (S)-dimethylaminomethyl-10-hydroxycamptothecin…”
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Degradation of suramin in aqueous solutions by Kettenes-van den Bosch, J.J, Hop, E, Overbeek, W, Underberg, W.J.M, Beijnen, J.H, Bult, A

“…The stability of suramin, a symmetrical urea derivative with a broad pharmacological profile, was investigated in aqueous solution in the pH/H 0 range −1–13,…”
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Determination of 4-hydroxyifosfamide in biological matrices by high-performance liquid chromatography by Kaijser, G.P., Ter Riet, P.G.J.H., de Kraker, J., Bult, A., Beijnen, J.H., Underberg, W.J.M.

“…A high-performance liquid chromatographic method has been developed for the determination of 4-hydroxyifosfamide, a metabolite of ifosfamide, in plasma of…”
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Inclusion complexation of doxorubicin and daunorubicin with cyclodextrins by Bekers, O, Beijnen, J H, Otagiri, M, Bult, A, Underberg, W J

“…The interaction of alpha-, beta- and gamma-cyclodextrins with the anthracycline antibiotics doxorubicin and daunorubicin was investigated by LC, circular…”
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Reversed-phase high-performance liquid chromatography and capillary electrophoresis in the stability study of the neuropeptide growth factor antagonist [Arg6,D-Trp7,9,MePhe8]-substance P (6-11): a comparative study by Reubsaet, J L, Beijnen, J H, Bult, A, Teeuwsen, J, Koster, E H, Waterval, J C, Underberg, W J

“…Reversed-phase high-performance liquid chromatography and capillary zone electrophoresis are widely used in protein and peptide analysis. Degradation of the…”
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Degradation Kinetics of Antagonist [Arg 6, D-Trp 7,9, MePhe 8]-Substance-P {6-11} in Aqueous Solutions by Reubsaet, J.L.E., Beijnen, J.H., Bult, A., Vanderhouwen, O.A.G.J., Teeuwsen, J., Koster, E.H.M., Underberg, W.J.M.

“…Antagonist [Arg 6, D-Trp 7,9, MePhe 8]-substance P {6-11} was subjected to a systematic stability study in which kinetic parameters were obtained for the…”
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Volume 220, Number 1 (1994), in the article "Reversed-Phase High-Performance Liquid Chromatography and Capillary Electrophoresis in the Stability Study of the Neuropeptide Growth Factor Antagonist [Arg6,D-Trp7,9,MePhe8]-Substance P{6-11}: A Comparative Study," pp 98–102 by Reubsaet, J.L.E., Beijnen, J.H., Bult, A., Teeuwsen, J., Koster, H.M., Waterval, J.C.M., Underberg, W.J.M.

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