Search Results - "Undem, Clark"

Hydrogen peroxide-induced calcium influx in lung microvascular endothelial cells involves TRPV4 by Suresh, Karthik, Servinsky, Laura, Reyes, Jose, Baksh, Syeda, Undem, Clark, Caterina, Michael, Pearse, David B, Shimoda, Larissa A

“…In acute respiratory distress syndrome, both reactive oxygen species (ROS) and increased intracellular calcium ([Ca(2+)]i) are thought to play important roles…”
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Hypoxia enhances interactions between Na + /H + exchanger isoform 1 and actin filaments via ezrin in pulmonary vascular smooth muscle by Lade, Julie M, Andrade, Manuella R, Undem, Clark, Walker, Jasmine, Jiang, Haiyang, Yun, Xin, Shimoda, Larissa A

“…Exposure to hypoxia, due to high altitude or chronic lung disease, leads to structural changes in the pulmonary vascular wall, including hyperplasia and…”
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Acetazolamide prevents hypoxia-induced reactive oxygen species generation and calcium release in pulmonary arterial smooth muscle by Shimoda, Larissa A., Suresh, Karthik, Undem, Clark, Jiang, Haiyang, Yun, Xin, Sylvester, J.T., Swenson, Erik R.

“…Upon sensing a reduction in local oxygen partial pressure, pulmonary vessels constrict, a phenomenon known as hypoxic pulmonary vasoconstriction. Excessive…”
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Digoxin inhibits development of hypoxic pulmonary hypertension in mice by Abud, Edsel M, Maylor, Julie, Undem, Clark, Punjabi, Arjun, Zaiman, Ari L, Myers, Allen C, Sylvester, J. T, Semenza, Gregg L, Shimoda, Larissa A

“…Chronic hypoxia is an inciting factor for the development of pulmonary arterial hypertension. The mechanisms involved in the development of hypoxic pulmonary…”
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Endothelin-1 augments Na⁺/H⁺ exchange activity in murine pulmonary arterial smooth muscle cells via Rho kinase by Undem, Clark, Rios, Eon J, Maylor, Julie, Shimoda, Larissa A

“…Excessive production of endothelin-1 (ET-1), a potent vasoconstrictor, occurs with several forms of pulmonary hypertension. In addition to modulating vasomotor…”
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Hypoxia-induced migration in pulmonary arterial smooth muscle cells requires calcium-dependent upregulation of aquaporin 1 by Leggett, Kyle, Maylor, Julie, Undem, Clark, Lai, Ning, Lu, Wenju, Schweitzer, Kelly, King, Landon S, Myers, Allen C, Sylvester, J T, Sidhaye, Venkataramana, Shimoda, Larissa A

“…Pulmonary arterial smooth muscle cell (PASMC) migration is a key component of the vascular remodeling that occurs during the development of hypoxic pulmonary…”
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Kinase-dependent activation of voltage-gated Ca2+ channels by ET-1 in pulmonary arterial myocytes during chronic hypoxia by Luke, Trevor, Maylor, Julie, Undem, Clark, Sylvester, J T, Shimoda, Larissa A

“…Exposure to chronic hypoxia (CH) causes pulmonary hypertension. The vasoconstrictor endothelin-1 (ET-1) is thought to play a role in the development of hypoxic…”
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Role of Rho kinase and Na+/H+ exchange in hypoxia‐induced pulmonary arterial smooth muscle cell proliferation and migration by Walker, Jasmine, Undem, Clark, Yun, Xin, Lade, Julie, Jiang, Haiyang, Shimoda, Larissa A.

“…Abnormal proliferation and migration of pulmonary arterial smooth muscle cells (PASMCs) are hallmark characteristics of vascular remodeling in pulmonary…”
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Contribution of Elevated Intracellular Calcium to Pulmonary Arterial Myocyte Alkalinization during Chronic Hypoxia by Undem, Clark, Luke, Trevor, Shimoda, Larissa A.

“…In the lung, exposure to chronic hypoxia (CH) causes pulmonary hypertension, a debilitating disease. Development of this condition arises from increased…”
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Rho kinase and Na+/H+ exchanger mediate endothelin‐1‐induced pulmonary arterial smooth muscle cell proliferation and migration by Huetsch, John C., Walker, Jasmine, Undem, Clark, Lade, Julie, Yun, Xin, Baksh, Syeda, Jiang, Haiyang, Lai, Ning, Shimoda, Larissa A.

“…Excessive production of endothelin‐1 (ET‐1) has been observed in almost all forms of pulmonary hypertension. ET‐1, a highly potent vasoconstrictor, can also…”
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Intermittent hypoxia impairs glucose homeostasis in C57BL6/J mice: partial improvement with cessation of the exposure by Polak, Jan, Shimoda, Larissa A, Drager, Luciano F, Undem, Clark, McHugh, Holly, Polotsky, Vsevolod Y, Punjabi, Naresh M

“…Obstructive sleep apnea is associated with insulin resistance, glucose intolerance, and type 2 diabetes mellitus. Although several studies have suggested that…”
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Activation of hypoxia-inducible factor-1 in pulmonary arterial smooth muscle cells by endothelin-1 by Pisarcik, Sarah, Maylor, Julie, Lu, Wenju, Yun, Xin, Undem, Clark, Sylvester, J T, Semenza, Gregg L, Shimoda, Larissa A

“…Numerous cellular responses to hypoxia are mediated by the transcription factor hypoxia-inducible factor-1 (HIF-1). HIF-1 plays a central role in the…”
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CD36 mediates H2O2-induced calcium influx in lung microvascular endothelial cells by Suresh, Karthik, Servinsky, Laura, Reyes, Jose, Undem, Clark, Zaldumbide, Joel, Rentsendorj, Otgonchimeg, Modekurty, Sruti, Dodd-O, Jeffrey M, Scott, Alan, Pearse, David B, Shimoda, Larissa A

“…Elevated levels of reactive oxygen species and intracellular Ca play a key role in endothelial barrier dysfunction in acute lung injury. We previously showed…”
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Interactions between calcium and reactive oxygen species in pulmonary arterial smooth muscle responses to hypoxia by Shimoda, Larissa A, Undem, Clark

“…Abstract In contrast to the systemic vasculature, where hypoxia causes vasodilation, pulmonary arteries constrict in response to hypoxia. The mechanisms…”
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Endothelin-1 Augments Na.sup.+/H.sup.+ Exchange Activity in Murine Pulmonary Arterial Smooth Muscle Cells via Rho Kinase by Undem, Clark, Rios, Eon J, Maylor, Julie, Shimoda, Larissa A

“…Excessive production of endothelin-1 (ET-1), a potent vasoconstrictor, occurs with several forms of pulmonary hypertension. In addition to modulating vasomotor…”
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Interactions between calcium and reactive oxygen species in pulmonary arterial smooth muscle responses to hypoxia: Physiological Redox: Regulation in Respiratory, Vascular, and Neural Cells by SHIMODA, Larissa A, UNDEM, Clark

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The C‐terminal tail of Aquaporin 1(AQP1) is Required for Migration and Proliferation of Pulmonary Arterial Smooth Muscle Cells (PASMCs) by Lai, Ning, Lade, Julie M, Leggett, Kyle, Undem, Clark, Crow, Michael, Yun, Xin, Shimoda, Larissa A

“…Abstract only Both PASMC proliferation and migration are important contributors to the vascular remodeling that occurs during the development of pulmonary…”
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Over‐ expression of wild‐type Na+/H+ exchanger isoform 1 (NHE1) in Pulmonary Arterial Smooth Muscle Cells (PASMCs) Stimulates Migration and Growth by Maylor, Julie, Undem, Clark, Crow, Michael T, Shimoda, Larissa A

“…Prolonged exposure to hypoxia results in pulmonary hypertension due to contraction, proliferation and migration of PASMCs. Increased PASMC proliferation and…”
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Role of Na+/H+ Exchange (NHE) in hypoxia‐induced pulmonary arterial smooth muscle cell (PASMC) growth and migration by Undem, Clark, Walker, Jasmine, Shimoda, Larissa A

“…Abstract only In many lung diseases, chronic hypoxia (CH) causes pulmonary hypertension resulting in part from vascular remodeling due to growth/migration of…”
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Aquaporin 1(AQP1) Mediates Migration and Growth in Pulmonary Arterial Smooth Muscle Cells (PASMCs) by Lai, Ning, Maylor, Julie, Leggett, Kyle, Undem, Clark, Crow, Michael, Shimoda, Larissa

“…Abstract only PASMC proliferation and migration is important for many pathological processes, including the development of pulmonary hypertension; however, the…”
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