Search Results - "Unbehauen, Michael"

Biodegradable Core⁻Multishell Nanocarriers: Influence of Inner Shell Structure on the Encapsulation Behavior of Dexamethasone and Tacrolimus by Unbehauen, Michael L, Fleige, Emanuel, Paulus, Florian, Schemmer, Brigitta, Mecking, Stefan, Moré, Sam Dylan, Haag, Rainer

“…We here present the synthesis and characterization of a set of biodegradable core⁻multishell (CMS) nanocarriers. The CMS nanocarrier structure consists of…”
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Stratum Corneum Targeting by Dendritic Core-Multishell-Nanocarriers in a Mouse Model of Psoriasis by Pischon, Hannah, DVM, Radbruch, Moritz, DVM, Ostrowski, Anja, DVM, PhD, Volz, Pierre, M.Sc, Gerecke, Christian, PhD, Unbehauen, Michael, Dipl.-NanoSc, Hönzke, Stefan, Hedtrich, Sarah, PhD, Fluhr, Joachim W., MD, PhD, Haag, Rainer, PhD, Kleuser, Burkhard, PhD, Alexiev, Ulrike, PhD, Gruber, Achim D., DVM, PhD, Mundhenk, Lars, DVM, PhD

“…Abstract Inflammatory disorders of the skin pose particular therapeutic challenges due to complex structural and functional alterations of the skin barrier…”
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Nanocrystals for Improved Drug Delivery of Dexamethasone in Skin Investigated by EPR Spectroscopy by Lohan, Silke B, Saeidpour, Siavash, Colombo, Miriam, Staufenbiel, Sven, Unbehauen, Michael, Wolde-Kidan, Amanuel, Netz, Roland R, Bodmeier, Roland, Haag, Rainer, Teutloff, Christian, Bittl, Robert, Meinke, Martina C

“…Nanocrystals represent an improvement over the traditional nanocarriers for dermal application, providing the advantages of 100% drug loading, a large surface…”
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Serine Protease-Mediated Cutaneous Inflammation: Characterization of an Ex Vivo Skin Model for the Assessment of Dexamethasone-Loaded Core Multishell-Nanocarriers by Frombach, Janna, Rancan, Fiorenza, Kübrich, Katharina, Schumacher, Fabian, Unbehauen, Michael, Blume-Peytavi, Ulrike, Haag, Rainer, Kleuser, Burkhard, Sabat, Robert, Wolk, Kerstin, Vogt, Annika

“…Standard experimental set-ups for the assessment of skin penetration are typically performed on skin explants with an intact skin barrier or after a partial…”
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pH-sensitive Eudragit® L 100 nanoparticles promote cutaneous penetration and drug release on the skin by Dong, Pin, Sahle, Fitsum Feleke, Lohan, Silke B., Saeidpour, Siavash, Albrecht, Stephanie, Teutloff, Christian, Bodmeier, Roland, Unbehauen, Michael, Wolff, Christopher, Haag, Rainer, Lademann, Jürgen, Patzelt, Alexa, Schäfer-Korting, Monika, Meinke, Martina C.

“…Nanoparticles (NPs) are promising carriers for dermal and transdermal drug delivery. However, the underlying dynamics of drug release from the NPs, especially,…”
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Rhamnolipids form drug-loaded nanoparticles for dermal drug delivery by Müller, Felix, Hönzke, Stefan, Luthardt, Wulf-Ole, Wong, Ee Lin, Unbehauen, Michael, Bauer, Jörg, Haag, Rainer, Hedtrich, Sarah, Rühl, Eckart, Rademann, Jörg

“…[Display omitted] Bacterial biosurfactants are nature’s strategy to solubilize and ingest hydrophobic molecules and nutrients using a fully biodegradable…”
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Core-multishell nanocarriers enhance drug penetration and reach keratinocytes and antigen-presenting cells in intact human skin by Frombach, Janna, Unbehauen, Michael, Kurniasih, Indah N., Schumacher, Fabian, Volz, Pierre, Hadam, Sabrina, Rancan, Fiorenza, Blume-Peytavi, Ulrike, Kleuser, Burkhard, Haag, Rainer, Alexiev, Ulrike, Vogt, Annika

“…In reconstructed skin and diffusion cell studies, core-multishell nanocarriers (CMS-NC) showed great potential for drug delivery across the skin barrier…”
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Faster, sharper, more precise: Automated Cluster-FLIM in preclinical testing directly identifies the intracellular fate of theranostics in live cells and tissue by Brodwolf, Robert, Volz-Rakebrand, Pierre, Stellmacher, Johannes, Wolff, Christopher, Unbehauen, Michael, Haag, Rainer, Schäfer-Korting, Monika, Zoschke, Christian, Alexiev, Ulrike

“…Fluorescence microscopy is widely used for high content screening in 2D cell cultures and 3D models. In particular, 3D tissue models are gaining major…”
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Preclinical Testing of Dendritic Core–Multishell Nanoparticles in Inflammatory Skin Equivalents by Graff, Patrick, Hönzke, Stefan, Joshi, Aaroh Anand, Yealland, Guy, Fleige, Emanuel, Unbehauen, Michael, Schäfer-Korting, Monika, Hocke, Andreas, Haag, Rainer, Hedtrich, Sarah

“…Human skin equivalents emerged as novel tools in preclinical dermatological research. It is being claimed that they may bridge the translational gap between…”
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Tailored dendritic core-multishell nanocarriers for efficient dermal drug delivery: A systematic top-down approach from synthesis to preclinical testing by Hönzke, Stefan, Gerecke, Christian, Elpelt, Anja, Zhang, Nan, Unbehauen, Michael, Kral, Vivian, Fleige, Emanuel, Paulus, Florian, Haag, Rainer, Schäfer-Korting, Monika, Kleuser, Burkhard, Hedtrich, Sarah

“…Drug loaded dendritic core-multishell (CMS) nanocarriers are of especial interest for the treatment of skin diseases, owing to their striking dermal delivery…”
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Crosstalk between core-multishell nanocarriers for cutaneous drug delivery and antigen-presenting cells of the skin by Edlich, Alexander, Volz, Pierre, Brodwolf, Robert, Unbehauen, Michael, Mundhenk, Lars, Gruber, Achim D., Hedtrich, Sarah, Haag, Rainer, Alexiev, Ulrike, Kleuser, Burkhard

“…Owing their unique chemical and physical properties core-multishell (CMS) nanocarriers are thought to underlie their exploitable biomedical use for a topical…”
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Drug distribution in nanostructured lipid particles by Saeidpour, Siavash, Lohan, Silke B., Solik, Agnieszka, Paul, Victoria, Bodmeier, Roland, Zoubari, Gaith, Unbehauen, Michael, Haag, Rainer, Bittl, Robert, Meinke, Martina C., Teutloff, Christian

“…[Display omitted] The targeted design of nanoparticles for efficient drug loading and defined release profiles is even after 25years of research on lipid-based…”
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Dendritic Core-Multishell Nanocarriers in Murine Models of Healthy and Atopic Skin by Radbruch, Moritz, Pischon, Hannah, Ostrowski, Anja, Volz, Pierre, Brodwolf, Robert, Neumann, Falko, Unbehauen, Michael, Kleuser, Burkhard, Haag, Rainer, Ma, Nan, Alexiev, Ulrike, Mundhenk, Lars, Gruber, Achim D.

“…Dendritic hPG-amid-C18-mPEG core-multishell nanocarriers (CMS) represent a novel class of unimolecular micelles that hold great potential as drug transporters,…”
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Investigation of the cutaneous penetration behavior of dexamethasone loaded to nano-sized lipid particles by EPR spectroscopy, and confocal Raman and laser scanning microscopy by Lohan, Silke B., Saeidpour, Siavash, Solik, Agnieszka, Schanzer, Sabine, Richter, Heike, Dong, Pin, Darvin, Maxim E., Bodmeier, Roland, Patzelt, Alexa, Zoubari, Gaith, Unbehauen, Michael, Haag, Rainer, Lademann, Jürgen, Teutloff, Christian, Bittl, Robert, Meinke, Martina C.

“…[Display omitted] An improvement of the penetration efficiency combined with the controlled release of actives in the skin can facilitate the medical treatment…”
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Tailor‐Made Core‐Multishell Nanocarriers for the Delivery of Cationic Analgesics to Inflamed Tissue by Unbehauen, Michael L., Łabuz, Dominika, Schwarzl, Richard, Moré, Sam, Netz, Roland R., Stein, Christoph, Machelska, Halina, Haag, Rainer

“…U50,488H (U50) is a κ‐opioid receptor agonist exerting effective analgesia in animal pain models. Yet, side effects such as sedation and depression‐like…”
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