Search Results - "Unakar, Nalin J."

UVA Light In vivo Reaches the Nucleus of the Guinea Pig Lens and Produces Deleterious, Oxidative Effects by Giblin, Frank J., Leverenz, Victor R., Padgaonkar, Vanita A., Unakar, Nalin J., Dang, Loan, Lin, Li-Ren, Lou, Marjorie F., Reddy, Venkat N., Borchman, Douglas, Dillon, James P.

“…The possible role of ultraviolet light in the formation of cataract is not well understood. In this study, guinea pigs were exposed to a chronic, low level of…”
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Glutathione Peroxidase-1 Deficiency Leads to Increased Nuclear Light Scattering, Membrane Damage, and Cataract Formation in Gene-Knockout Mice by Reddy, Venkat N, Giblin, Frank J, Lin, Li-Ren, Dang, Loan, Unakar, Nalin J, Musch, David C, Boyle, Daniel L, Takemoto, Larry J, Ho, Ye-Shih, Knoernschild, Tina, Juenemann, Anselm, Lutjen-Drecoll, Elke

“…Previous in vitro studies with transgenic and gene-knockout mice have shown that lenses with elevated levels of glutathione peroxidase (GPX)-1 activity are…”
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Effect of germanium-132 on galactose cataracts and glycation in rats by Unakar, Nalin J., Johnson, Margaret, Tsui, Jane, Cherian, Mary, Abraham, Edathara C.

“…Germanium compounds have been shown to be effective in preventing the formation of advanced glycation end-products and for reversible solubilization of…”
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Nuclear light scattering, disulfide formation and membrane damage in lenses of older guinea pigs treated with hyperbaric oxygen by Giblin, Frank J., Padgaonkar, Vanita A., Leverenz, Victor R., Lin, Li-Ren, Lou, Marjorie F., Unakar, Nalin J., Dang, Loan, Dickerson, Jaime E., Reddy, Venkat N.

“…Nuclear cataract, a major cause of loss of lens transparency in the aging human, has long been thought to be associated with oxidative damage, particularly at…”
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Ocular lens and galactose cataracts by Unakar, N J

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Effect of pretreatment of germanium-132 on Na+-K+-ATPase and galactose cataracts by Unakar, Nalin J., Tsui, Jane, Johnson, Margaret

“…PURPOSE. Recently, we reported that topical administration of 2-carboxyethyl germanium sesquioxide (Ge-132) concurrently with 50% galactose feeding delayed the…”
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Lenticular alterations in hypertensive rats by Unakar, N J, Johnson, M

“…Cataract development has been reported in Dahl salt-sensitive (DS) hypertensive rats with high-salt intake. An alteration in ionic transport and electrolyte…”
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Evaluation of lens epithelial cell differentiation by quantitation of MP26 mRNA relative to gamma-crystallin mRNA in initiation of galactose cataracts in the rat by Wen, Y, Unakar, N J, Bekhor, I

“…It is well established that in response to feeding of galactose to four-week-old rats cataracts develop (Unakar, Genyea, Reddan & Reddy, Exp. Eye Res. 26,…”
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Transient elevation of aldose reductase mRNA in lens of rats developing galactose cataracts by SHI, S, UNAKAR, N. J, WEN, Y, TSUI, J, BEKHOR, I

“…Aldose reductase (AR), a major enzyme in the polyol pathway, is thought to be responsible for accumulation of polyols in lenses exposed to high doses of…”
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Management of aldose reductase mRNA abundance in rat lens undergoing reversal of galactose induced cataracts. A model for gene response to changes in the environment by Bekhor, I, Shi, S T, Unakar, N J

“…Aldose reductase (AR) mRNA concentration in rat lens was quantitated by hybridization of a RNA transcript from a previously described AR cDNA clone to mRNA…”
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In utero and milk-mediated effect of aldose reductase inhibitor on galactose cataracts by Unakar, N J, Tsui, J Y, Johnson, M, Dang, L

“…Our previously reported investigations showed that cataracts could be induced in fetal lenses through the maternal feeding of galactose during pregnancy. We…”
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Expression of c-myc protooncogene in rat lens cells during development, maturation and reversal of galactose cataracts by WEN, Y, SHU, S, UNAKAR, N. J, BEKHOR, I

“…It is well established that normal patterns of epithelial cell proliferation and metabolism, and of fiber cell differentiation and maturation are essential for…”
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Relative abundance of aldose reductase mRNA in rat lens undergoing development of osmotic cataracts by Bekhor, I, Shi, S, Carper, D, Nishimura, C, Unakar, N J

“…Aldose reductase (AR) messenger RNA concentration was determined in normal rat lens and in lens from rats fed a 50% galactose diet over a period of 20 days…”
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Aldose reductase inhibitors and galactose toxicity in neonatal and maternal rat lenses by Unakar, N J, Tsui, J, Anthony, P, Johnson, M

“…We reported that in utero galactose-induced cataracts could be inhibited if aldose reductase inhibitors (ARIs) were included in the galactose diet of pregnant…”
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Sodium-potassium-dependent ATPase. III. Cytochemical localization during the reversal of in utero induced galactose cataracts in rat by Unakar, N J, Tsui, J

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Effect of aldose reductase inhibitors on lenticular dulcitol level in galactose fed rats by Unakar, N J, Tsui, J Y, Johnson, M J

“…We have shown that galactose cataract development is delayed or inhibited with the administration of aldose reductase inhibitors (ARIs). Dulcitol forms and…”
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p-Hydroxypropiophenone effects on azo dye-induced alterations in mouse hepatic cells: light and electron microscopic study by Unakar, N J

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Survival of fiber cells and fiber-cell messenger RNA in lens of rats maintained on a 50% galactose diet for 45 days by Hsu, M Y, Jaskoll, T F, Unakar, N J, Bekhor, I

“…Previous work from this laboratory has shown that in cataractous lens from rats fed a 50% galactose diet up to 32 days, synthesis of crystallin mRNAs was…”
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Ultrastructural cytochemistry: effect of Sorbinil on arylsulfatases in cataractous lenses by Harries, W, Tsui, J, Unakar, N J

“…We have demonstrated an increase in activity of arylsulfatase A and B during galactose induced cataract development in rats. Our recent investigation shows…”
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Sodium-potassium-dependent-ATPase activity in Emory mouse lens by Unakar, N J, Tsui, J Y, Kuck, J F, Kuck, K D

“…Previous morphological and biochemical studies indicate that a late appearing hereditary Emory mouse cataract may be a good model for certain human senile…”
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