Search Results - "Unadkat, Vishal"

Synthesis and structure–activity relationship of potent, selective and orally active anthranilamide-based factor Xa inhibitors: Application of weakly basic sulfoximine group as novel S4 binding element by Pandya, Vrajesh, Jain, Mukul, Chakrabarti, Ganes, Soni, Hitesh, Parmar, Bhavesh, Chaugule, Balaji, Patel, Jigar, Jarag, Tushar, Joshi, Jignesh, Joshi, Nirav, Rath, Akshyaya, Unadkat, Vishal, Sharma, Bhavesh, Ajani, Haresh, Kumar, Jeevan, Sairam, Kalapatapu V.V.M., Patel, Harilal, Patel, Pankaj

“…A novel series of potent and efficacious factor Xa inhibitors which possesses sulfoximine moiety as novel S4 binding element in anthranilamide chemotype has…”
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Bioisosteric replacement of dihydropyrazole of 4S-(-)-3-(4-chlorophenyl)-N-methyl-N'-[(4-chlorophenyl)-sulfonyl]-4-phenyl-4,5-dihydro-1H-pyrazole-1-caboxamidine (SLV-319) a potent CB1 receptor antagonist by imidazole and oxazole by Srivastava, Brijesh Kumar, Soni, Rina, Joharapurkar, Amit, Sairam, Kalapatapu V V M, Patel, Jayendra Z, Goswami, Amitgiri, Shedage, Sandeep A, Kar, Sidhartha S, Salunke, Rahul P, Gugale, Shivaji B, Dhawas, Amol, Kadam, Pravin, Mishra, Bhupendra, Sadhwani, Nisha, Unadkat, Vishal B, Mitra, Prasenjit, Jain, Mukul R, Patel, Pankaj R

“…Design, synthesis and conformational analysis of few imidazole and oxazole as bioisosters of…”
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MP03-01 THE EVOLVING STORY OF PHENAZOPYRIDINE: EXPLORING THE PHARMACOLOGICAL EFFECTS IN ANIMAL MODELS OF INTERSTITIAL CYSTITIS/BLADDER PAIN SYNDROME by Purohit, Parva, Pandya, Heta, Jash, Kavya, Unadkat, Vishal, Variya, Ketan, Sangle, Ganesh

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Rational design-aided discovery of novel 1,2,4-oxadiazole derivatives as potential EGFR inhibitors by Unadkat, Vishal, Rohit, Shishir, Parikh, Paranjay, Sanna, Vinod, Singh, Sanjay

“…[Display omitted] A molecular dynamics-based sampling of epidermal growth factor receptor tyrosine kinase (EGFR-TK) was carried out to search for energetically…”
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Corrigendum to “Rational design-aided discovery of novel 1,2,4-oxadiazole derivatives as potential EGFR inhibitors” [Bioorg. Chem. 114 (2021) 105124] by Unadkat, Vishal, Rohit, Shishir, Parikh, Paranjay, Sanna, Vinod, Singh, Sanjay, Patel, Kaushal

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Identification of 1,2,4-Oxadiazoles-Based Novel EGFR Inhibitors: Molecular Dynamics Simulation-Guided Identification and in vitro ADME Studies by Unadkat, Vishal, Rohit, Shishir, Parikh, Paranjay, Patel, Kaushal, Sanna, Vinod, Singh, Sanjay

“…In this work, we have identified heterocyclic derivatives with 1,2,4 oxadiazole scaffold mimicking the functions of tyrosine kinase inhibitors. Fourteen…”
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Abstract 1616: Preclinical characterization of KSHN001126, a novel, differentiated and steroidal oral selective estrogen receptor degrader (SERD) by Purohit, Parva, Pandya, Heta, Unadkat, Vishal, Variya, Ketan, Sinha, Sonam, Barmade, Mahesh, Rohit, Shishir, Sangle, Ganesh

“…Abstract Fulvestrant (FLV) (Faslodex®) is the only clinically approved steroidal SERD that requires painful intramuscular administration. Several oral SERDs…”
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Abstract 4043: KSHN001034: An intramuscular prodrug of fulvestrant to treat estrogen-receptor (ER) positive advanced metastatic breast cancer by Pandya, Heta, Sangle, Ganesh, Unadkat, Vishal, Goswami, Vishal, Purohit, Parva, Mehta, Chirag, Sinha, Sonam, Variya, Ketan

“…Abstract Purpose: Breast cancer (BC) remains a considerable health concern, with over 75% of total cases accounting for ER+ BC. Fulvestrant, a selective…”
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Abstract 3356: Comparative analysis of approved and undertrial SERDs in estrogen receptor-α (ERα): An in-silico approach by Unadkat, Vishal, Rohit, Shishir, Purohit, Parva, Mehta, Chirag, Goswami, Vishal, Barmade, Mahesh, Sinha, Sonam, Sangle, Ganesh

“…Abstract Background: Despite recent advancements in early detection and treatment, breast cancer is the second most common cancer affecting women globally,…”
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Abstract 3077: Pharmacological profiling of KSHN001034 - A novel prodrug of Fulvestrant with improved efficacy by Purohit, Parva, Pandya, Heta, Unadkat, Vishal, Mehta, Sandip, Variya, Ketan, Sinha, Sonam, Barmade, Mahesh, Krishna, Vamsi, Sangle, Ganesh

“…Abstract Purpose: KSHN001034, a Fulvestrant (FLV) prodrug, was developed to enhance solubility and achieve higher FLV plasma exposures. Currently, Faslodex®…”
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Design, Synthesis of Novel, Potent, Selective, Orally Bioavailable Adenosine A2A Receptor Antagonists and Their Biological Evaluation by Basu, Sujay, Barawkar, Dinesh A, Thorat, Sachin, Shejul, Yogesh D, Patel, Meena, Naykodi, Minakshi, Jain, Vaibhav, Salve, Yogesh, Prasad, Vandna, Chaudhary, Sumit, Ghosh, Indraneel, Bhat, Ganesh, Quraishi, Azfar, Patil, Harish, Ansari, Shariq, Menon, Suraj, Unadkat, Vishal, Thakare, Rhishikesh, Seervi, Madhav S, Meru, Ashwinkumar V, De, Siddhartha, Bhamidipati, Ravi K, Rouduri, Sreekanth R, Palle, Venkata P, Chug, Anita, Mookhtiar, Kasim A

“…Our initial structure–activity relationship studies on 7-methoxy-4-morpholino-benzothiazole derivatives featured by aryloxy-2-methylpropanamide moieties at the…”
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Design, Synthesis of Novel, Potent, Selective, Orally Bioavailable Adenosine A 2A Receptor Antagonists and Their Biological Evaluation by Basu, Sujay, Barawkar, Dinesh A, Thorat, Sachin, Shejul, Yogesh D, Patel, Meena, Naykodi, Minakshi, Jain, Vaibhav, Salve, Yogesh, Prasad, Vandna, Chaudhary, Sumit, Ghosh, Indraneel, Bhat, Ganesh, Quraishi, Azfar, Patil, Harish, Ansari, Shariq, Menon, Suraj, Unadkat, Vishal, Thakare, Rhishikesh, Seervi, Madhav S, Meru, Ashwinkumar V, De, Siddhartha, Bhamidipati, Ravi K, Rouduri, Sreekanth R, Palle, Venkata P, Chug, Anita, Mookhtiar, Kasim A

“…Our initial structure-activity relationship studies on 7-methoxy-4-morpholino-benzothiazole derivatives featured by aryloxy-2-methylpropanamide moieties at the…”
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Bioisosteric replacement of dihydropyrazole of 4 S-(−)-3-(4-chlorophenyl)- N-methyl- N′-[(4-chlorophenyl)-sulfonyl]-4-phenyl-4,5-dihydro-1H-pyrazole-1-caboxamidine (SLV-319) a potent CB1 receptor antagonist by imidazole and oxazole by Srivastava, Brijesh Kumar, Soni, Rina, Joharapurkar, Amit, Sairam, Kalapatapu V.V.M., Patel, Jayendra Z., Goswami, Amitgiri, Shedage, Sandeep A., Kar, Sidhartha S., Salunke, Rahul P., Gugale, Shivaji B., Dhawas, Amol, Kadam, Pravin, Mishra, Bhupendra, Sadhwani, Nisha, Unadkat, Vishal B., Mitra, Prasenjit, Jain, Mukul R., Patel, Pankaj R.

“…Design, synthesis and conformational analysis of few imidazole and oxazole as bioisosters of 4 S-(−)-3-(4-chlorophenyl)- N-methyl-…”
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Bioisosteric replacement of dihydropyrazole of 4S-(-)-3-(4-chlorophenyl)-N-methyl-N'-[(4-chlorophenyl)-sulfonyl]-4-phenyl-4,5-dihydro-lH-pyrazole-1-caboxamidine (SLV-319) a potent CB1 receptor antagonist by imidazole and oxazole by BRIJESH KUMAR SRIVASTAVA, SONI, Rina, DHAWAS, Amol, KADAM, Pravin, MISHRA, Bhupendra, SADHWANI, Nisha, UNADKAT, Vishal B, MITRA, Prasenjit, JAIN, Mukul R, PATEL, Pankaj R, JOHARAPURKAR, Amit, SAIRAM, Kalapatapu V. V. M, PATEL, Jayendra Z, GOSWAMI, Amitgiri, SHEDAGE, Sandeep A, KAR, Sidhartha S, SALUNKE, Rahul P, GUGALE, Shivaji B

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